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non-apoptotic cell death-based cancer therapy:Molecular mechanism,pharmacological modulators,and nanomedicine

Acta Pharmaceutica Sinica B 2022年第9期12卷 3567-3593页

作者： Xuan Wang Peng Hua Chengwei He Meiwan Chen State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacaoSAR 999078China

As an emerging cancer therapeutic target,non-apoptotic cell death such as ferroptosis,necroptosis and pyroptosis,etc.,has revealed significant potential in cancer treatment for bypassing apoptosis to enhance the undermined therapeutic efficacy triggered by apoptosis resistance.A variety of anticancer drugs,synthesized compounds and natural products have been proven recently to induce non-apoptotic cell death and exhibit excellent anti-tumor ***,the convergence of nanotechnology with functional materials and biomedicine science has provided tremendous opportunities to construct non-apoptotic cell death-based nanomedicine for innovative cancer *** are not only employed in targeted delivery of non-apoptotic inducers,but also used as therapeutic components to induce non-apoptotic cell death to achieve efficient tumor *** review first introduces the main characteristics,the mechanism and various pharmacological modulators of different non-apoptotic cell death forms,including ferroptosis,necroptosis,pyroptosis,autophagy,paraptosis,lysosomal-dependent cell death,and ***,we comprehensively review the latest progresses of nanomedicine that induces various forms of non-apoptotic cell death and focus on the nanomedicine targeting different pathways and ***,the combination therapies of non-apoptotic cell death with photothermal therapy,photodynamic therapy,immunotherapy and other modalities are ***,the challenges and future perspectives in this regard are also discussed.

关键词： non-apoptotic cell death Ferroptosis Necroptosis Pyroptosis Autophagy Nanomedicine Combination therapies Anticancer

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Recent advances in natural compounds inducing non-apoptotic cell death for anticancer drug resistance

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Cancer Drug Resistance 2023年第4期6卷 729-747页

作者： Jia-Wen Chen Sibao Chen Guo-Qing Chen Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical CollegeBejing 100193China State Key Laboratory of Chinese Medicine and Molecular Pharmacology(Incubation) The Hong Kong Polytechnic University Shenzhen Research InstituteShenzhen 518057GuangdongChina Department of Food Science and Nutrition The Hong Kong Polytechnic UniversityHung HomHong Kong 999077China Research Centre for Chinese Medicine Innovation The Hong Kong Polytechnic UniversityHung HomHong Kong 999077China

The induction of cell death is recognized as a potent strategy for cancer *** is an extensively studied form of cell death,and multiple anticancer drugs exert their therapeutic effects by inducing ***,apoptosis evasion is a hallmark of cancer,rendering cancer cells resistant to chemotherapy ***,there is a growing interest in exploring novel non-apoptotic forms of cell death,such as ferroptosis,necroptosis,pyroptosis,and *** compounds with anticancer properties have garnered significant attention due to their advantages,including a reduced risk of drug *** the past two decades,numerous natural compounds have been discovered to exert anticancer and anti-resistance effects by triggering these four non-apoptotic cell death *** review primarily focuses on these four non-apoptotic cell death mechanisms and their recent advancements in overcoming drug resistance in cancer ***,it highlights the role of natural compounds in effectively addressing cancer drug resistance through the induction of these forms of non-apoptoticcell death.

关键词： Drug resistance cancer therapy natural compound non-apoptotic cell death

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