检索结果-南通市图书馆

nitrogenation of Amides via C–C and C–N Bond Cleavage

CCS Chemistry 2023年第5期5卷 1061-1068页

作者： Ming-Hui Zhu Zengrui Cheng Jialiang Wei Hui Tan Ning Jiao State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191 State Key Laboratory of Organometallic Chemistry Sciences Chinese Academy of SciencesShanghai 200032

Amides are among the fundamental chemicals in organic *** to other carbonyl functional groups,the transformation of amide is relatively difficult and remains a *** traditional deconstruction transformations of amides to other functional products are usually limited to twisted or electronically activated ***,we describe a direct nitrogenation approach to convert amides into *** chemistry provides a novel amide transformation pathway via both C–C and C–N bond ***,the simple,readily available,and inexpensive inorganic salt NaNO2 is successfully employed as a nitrogen source in this organic N-incorporation *** of this study are demonstrated through the latestage modification of drug and natural product derivatives.

关键词： amide activation C–C cleavage C–N cleavage nitrogenation nitriles synthesis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

nitrogenation Process of Nd(Fe, Mo)_(12) Compound

引用

International Journal of Minerals,Metallurgy and Materials 1998年第2期12卷 97-99页

作者： Qi Zeng Yiaofu Xiao Yunshen Deng Xubo Liu Shenzhi Dong Materials Science and Engineering School, UST Beijing, Beijing 100083, China Materials Science and Engineering School UST Beijing Beijing 100083 China

The reaction kinetics between nitrogen gas and Nd(Fe, Mo)_(12) intermetallic compound has been studied. The relationship between the reaction temperature, the reaction time with average mass fraction of N in samples have been measured. The activation energy of first step reaction, E_f,(18.2 kJ/mol), is smaller than E_s (64.6 kJ /mol) of the second step during which nitrogen diffusion in the range 400～550℃ can be represented by an activated interstitial diffusion process. Heating above 550℃ leads to disproportion of the compound into NdN and α-Fe and the permanent properties will be damaged greatly.

关键词： Nd(Fe Mo)_(12) nitrogenation activation energy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Corrosion mechanism of H_2O on Sm_2Fe_(17) and nitrogenation process of corroded Sm_2Fe_(17)

引用

Journal of Rare Earths 2019年第6期37卷 638-644页

作者： Jianwei Xu Jingwu Zheng Haibo Chen Liang Qiao Yao Ying Wei Cai Wangchang Li Jing Yu Min Lin Shenglei Che Research Center of Magnetic and Electronic Materials College of Materials Science and EngineeringZhejiang University of Technology Key Laboratory of Magnetic Materials and Devices Ningbo Institute of Material Technology & EngineeringChinese Academy of Sciences

Sm_2 Fe_(17) prepared by reduction-diffusion method needs to be washed with water to remove calcium oxide. Electrochemical corrosion occurs when Sm_2 Fe_(17) powder is in contact with liquid water. Corrosion mechanism of H_2 O on Sm_2 Fe_(17) powder and nitrogenation process of corroded Sm_2 Fe_(17) were studied by analyzing the structure and morphology. It is indicated that the metallic hydroxide forms and deposits on the Sm_2 Fe_(17) powder surfaces during water corrosion. At the same time, oxygen and hydrogen enter the unit cell of Sm2 Fe_(17), causing a slight increase in Curie temperature. In the subsequent nitriding process,the hydroxide is dehydrated and hydrogen is desorbed. The resulting oxide reacts with Sm_2 Fe_(17)N_x to form a-Fe and Sm_2 O_3. Thermodynamic calculations using the HSC Chemistry 6.0 software indicate that the reaction can occur spontaneously. The effect of water corrosion on the magnetic properties of the nitride can be eliminated by hydrogen reduction prior to nitriding.

关键词： Sm2Fe17 nitrogenation Reduction-diffusion method Water corrosion α-Fe formation Rare earths

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

KI Catalyzed nitrogenation of Aldehydes and Alcohols： Direct Synthesis of Carbamoyl Azides and Ureas

引用

Chinese Journal of Chemistry 2017年第6期35卷 845-848页

作者： Song Song Peng Feng Miancheng Zou Ning Jiao State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences Peking University Beijing 100191 China Shanghai Key Laboratory of Green Chemistry and Chemical Processes East China Normal University Shanghai 200062 China

An efficient KI catalyzed nitrogenation of aldehydes and alcohols for the direct synthesis of carbamoyl azides and ureas via a radical process has been developed. The simple operating procedures, the readily available starting materials including aldehydes, alcohols and amines, as well as the utility of the products all make this strategy very attractive.

关键词： nitrogenation aldehydes carbamoyl azides ureas KI TBHP

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

nitrogenation of Alkynes,Olefins,and the Mechanistic Study

Nitrogenation of Alkynes,Olefins,and the Mechanistic Study

引用

中国化学会第30届学术年会-第四十五分会：物理有机

作者： Xinyao Li Tao Shen Xiaoqiang Huang Ning Jiao State Key Laboratory of Natural and Biomimetic Drugs Peking University

nitrogen-containing compounds are widely present in both natural products and synthetic compounds, for example, they show up within functional materials, top-selling drugs, as well as bioactive molecules. Thus, organic chemists have paid considerable attention in developing novel methodologies for their preparation. To synthesize these compounds in a green and sustainable way, researchers have focused on the direct functionalization of hydrocarbons via C–H and/or C–C bond cleavage. Although significant progress have made in the direct functionalization of simple hydrocarbons, direct incorporation of O-or N-atoms into the simple substrates via C–H and/or C–C bond cleavage remains challenging due to the inert chemical bonds and the unstable character of some N-sources under oxidative conditions. By using molecular oxygen as oxygen source as well as azides as nitrogen source, we recently developed some C-H/C-C bond oxygenation and nitrogenation reactions for the synthesis Oand/or N-containing compounds. In this presentation, our recent progress on the direct oxygenation and nitrogenation of olefins will be introduced.

关键词： nitrogenation Alkynes Olefins

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Highly Efficient Methodologies via C-C Bond nitrogenation

Highly Efficient Methodologies via C-C Bond Nitrogenation

引用

中国化学会全国第十一届有机合成化学学术研讨会

作者：焦宁 State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking University

The development of novel methods for the preparation of nitrogen-containing molecules has been of long-standing interest to organic chemists due to their great importance in chemistry and biology.1 Recently,we have developed some direct approaches to nitrogen-containing molecules by direct nitrogenation of simple molecules at mild conditions through oxidative C-H and C-C bond cleavage strategies employing NaN3,TMSN3,or DMF as the nitrogen source（Scheme 1）.In this talk,the details of these direct transformations as well as the recent development will be presented.

关键词： nitrogenation Oxidation Rearrangement Azides Cleavage

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Late-stage modification of bioactive compounds:Improving druggability through efficient molecular editing

引用

Acta Pharmaceutica Sinica B 2024年第3期14卷 1030-1076页

作者： Tongyu Huo Xinyi Zhao Zengrui Cheng Jialiang Wei Minghui Zhu Xiaodong Dou Ning Jiao State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Changping Laboratory Beijing 102206China Shanghai Key Laboratory of Green Chemistry and Chemical Processes East China Normal UniversityShanghai 200062China

Synthetic chemistry plays an indispensable role in drug discovery,contributing to hit compounds identification,lead compounds optimization,candidate drugs preparation,and so *** Nobel Prize laureate James Black emphasized,“the most fruitful basis for the discovery of a new drug is to start with an old drug”***-stage modification or functionalization of drugs,natural products and bioactive compounds have garnered significant interest due to its ability to introduce diverse elements into bioactive compounds *** modifications alter the chemical space and physiochemical properties of these compounds,ultimately influencing their potency and *** enrich a toolbox of chemical modification methods for drug discovery,this review focuses on the incorporation of halogen,oxygen,and nitrogen—the ubiquitous elements in pharmacophore components of the marketed drugs—through late-stage modification in recent two decades,and discusses the state and challenges faced in these *** also emphasize that increasing cooperation between chemists and pharmacists may be conducive to the rapid discovery of new activities of the functionalized ***,we hope this review would serve as a valuable resource,facilitating the application of late-stage modification in the construction of novel molecules and inspiring innovative concepts for designing and building new drugs.

关键词： Late-stage modification Drug space Halogenation Oxygenation nitrogenation Synthetic chemistry

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Selective Carbon-Carbon Bond Amination with Redox-Active Aminating Reagents:A Direct Approach to Anilines

引用

Chinese Journal of Chemistry 2021年第18期39卷 3011-3016页

作者： Xu Qiu Yachong Wang Lingyu Su Rui Jin Song Song Qixue Qin Junhua Li Baoning Zong Ning Jiao State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing100191 China State Key Laboratory of Catalytic Materials and Reaction Engineering Research Institute of Petroleum ProcessingSINOPEC100083 BeijingChina Shanghai Key Laboratory of Green Chemistry and Chemical Processes East China Normal UniversityShanghai200062 China

Amines are among the most fundamental motifs in chemical synthesis,and the introduction of amine building blocks via selective C-C bond cleavage allows the construction of nitrogen compounds from simple hydrocarbons through direct skeleton ***,we report a novel method for the preparation of anilines from alkylarenes via Schmidt-type rearrangement using redox-active amination reagents,which are easily prepared from *** amines and secondary amines were prepared from corresponding alkylarenes or benzyl alcohols under mild *** compatibility and valuable applications of the transformation were also displayed.

关键词： Anilines C-C activation Amination nitrogenation Arenes

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：