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Endogenous Ouabain in Hypertensive Disorder Complicating Pregnancy

Journal of Huazhong University of Science and Technology(Medical Sciences) 2007年第6期27卷 717-720页

作者：吴黎熊承良苏萍 Family Planning Research Institute Tongji Medical College Huazhong University of Science and Technology

Expression of endogenous ouabain in placenta and the concentrations of serum ET-1 and NO were examined in 30 patients with hypertensive disorder complicating pregnancy （HDCP） and 30 healthy pregnant women to investigate the effect of endogenous ouabain on HDCP. Compared with the healthy pregnant group, the expression of endogenous ouabain dramatically increased in the HDCP groups （P〈0.01）. There was a significantly positive correlation between the expression of en- dogenous ouabain with ET-1 （r= 0.5567, P〈0.01）, while the correlation of endogenous ouabain and NO was significantly negative （r=-0.6895, P〈0.01）. As expected, the correlation between ET-1 and NO was negative （r=-0.7796, P〈0.01）. ET-1 concentrations of maternal and cord sera in HDCP groups were significantly higher in comparison with healthy pregnant group （P〈0.01）. On the contrast, NO concentrations were much lower in the maternal and cord sera of HDCP groups as compared with healthy pregnant group （P〈0.01）. Our data suggest that endogenous ouabain is directly involved in the nosogenesis of HDCP, with accompanying decreased NO and the elevated of ET-1.

关键词： endogenous ouabain hypertensive disorder complicating pregnancy nitrogen monoxidum endothelin-1

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Effect of Mexican Tea Herb and Pilular Adina Herb on Concrescence of Gastric Mucosa in Experimental Gastric Ulcer Rats

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Chinese Journal of Integrative Medicine 2007年第2期13卷 132-136页

作者：曹名波董蕾苌新明邹百仓秦斌 Department of Digestive Medicine The Second Affiliated Hospital of Medical College Xi' an Jiaotong University

Objective： To study the effect and mechanism of mexican tea herb and pilular adina herb （abbreviated to MP） on concrescence of gastric mucosa in experimental gastric ulcer rats by observing the changes of epidermal growth factor （EGF）, nitrogen monoxidum （NO） and expression of epidermal growth factor receptor （EGFR）. Methods： The rat ulcer model was established by 100% glacial acetic injection into the subserosa. The ulcer index （UI） was measured by sliding caliper. The levels of NO and EGF in tissue and serum were measured by the nitrate reductase method and enzyme-linked immunosorbent assay, respectively. The expression of EGFR in the mucosa around the ulcer was detected by the immunohistochemical assay and microimage analysis system. Results：（1） Compared with the model group, UI of MP groups （10, 15 and 20 mg·kg^-1·d^-1） and ranitidine group was lower （P〈0.05 or P〈0.01）, the levels of NO and EGF in the tissue and serum were higher （P〈0.05）, the thickness of regenerated mucous membrane increased, and the width loss of lamina muscularis mucosa decreased （all P〈0.05）. （2） The expression of EGFR is weakly positive in gastric mucosa cells in the normal group, mainly in the cytoplasm and cytomembrane. In the model group, the expression of EGFR was mainly in epithelial cells in cervical part and basilar part of gastric gland around the ulcer margin, and the number of cells with EGFR weakly positive expression was more than that in the normal group. Compared with that in the normal and model groups, the number of cells with EGFR positive in MP groups and ranitidine group increased （all P〈0.05）, with weakly positive expression. Conclusion： MP can protect gastric mucosa, cure gastric ulcer, restrain the secretion of gastric acid, and boost multiplication, differentiation, migration and repair of the endothelial cell by promoting the secretion of NO and EGF, and increasing the expression of EGFR of gastric mucosa epithelial cells.

关键词： gastric ulcer epidermal growth factor nitrogen monoxidum epidermal growth factor receptor index of ulcer mexican tea herb pilular adina herb

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