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Spectrum-Toxicity Correlation Study Revealed the Influence of the nine-time steaming and sun drying Method on Hepatotoxic Components of Polygoni Multiflori Radix

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World Journal of Traditional Chinese Medicine 2021年第2期7卷 227-233页

作者： Zhuo Shi Xiao-Fei Li Ya-Lei Liu Peng-Yan Li Ming Niu Zhao-Fang Bai Guang-Qin Zhang Yang Lu Jia-Bo Wang Clinical Pharmacokinetics Laboratory School of Basic Medicine and Clinical PharmacyChina Pharmaceutical UniversityNanjing The Fifth Medical Center China Military Institute of Chinese MedicineGeneral Hospital of PLABeijingChina

Objective:Polygoni Multiflori Radix(PM)is a traditional herbal medicine with repeated reports of liver injury events in recent *** wondered whether the classical processing method,namely,nine-time steaming and sun drying(NSSD),had toxicity-attenuating effects on PM and the relationships between toxicity and times of processing,as well as with the alteration trends of its *** and Methods:The chemical fingerprints of different PM extracts were developed using ultra-high-performance liquid *** spectrum-toxicity correlation between the chemical fingerprints and hepatocellular toxicity was analyzed with multiple correlation ***:The results suggested that the hepatotoxicity of NSSD processing products markedly decreased with the repeated steaming and sun drying,which was obviously superior to the product processed by the modern *** analysis revealed that the contents of cis-stilbene glycoside and emodin-8-O-β-D-glucoside related to liver injury susceptibility were reduced with the times of NSSD processing,which was consistent with the decreased trend of hepatocellular *** the five times of NSSD,the contents of them as well as the hepatotoxicity of PM were ***,we found that the contents of catechin and physcion declined rapidly after the one time of NSSD and then remained stable until the nine times of *** on the fact,they could be utilized to indicate whether PM products were processed by steaming and sun ***:This paper confirmed that the NSSD had a good influence on the toxicity attenuating to PM and found four compounds which could apply for the quality control of PM.

关键词： Hepatotoxicity nine-time steaming and sun drying polygoni multiflori radix spectrum-toxicity correlation toxicity attenuation by processing

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