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A functional role of TRPMl-L retinal bipolar transduction channel

A functional role of TRPMl-L retinal bipolar transduction ch...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Takahisa Furukawa Osaka Bioscience Institute PRESTO JSTJapan

An essential step in intricate visual processing is the segregation of visual signals into ON and OFF pathways by retinal bipolar *** found that TRPM1-L is a component of the ON BC transduction channel. We identified a mouse trpm1 homologue of human ***1 is alternatively spliced,resulting in the production of a long form(trpm1-L) and a short N-terminal form(trpm1 -S).Although mouse trpm1-S was previously identified as melastatin,mouse trpm1-L was not *** distinction between trpm1-L or -S,trpm1 has been reported to be detected in human primary melanocytes,poorly metastatic melanoma cell lines,mouse retinal pigment epithelium (RPE),and subsets of ON and OFF *** found that TRPM 1 -L localization is developmentally restricted to the dendritic tips of ON BCs in co-localization with mouse GRM6(mGluR6).Trpm1-null mutant mice completely lose the photoresponse of ON ***1-L channel activity is negatively regulated by activated G in the mGluR6 *** examined if TRPM1-L is regulated by Goa or *** performed inside-out patch clamp in the presence of purified brain Goαor Gβγusing TRPM1-L expressing CHO *** then investigated a possible involvement of TRPM1 abnormality in pathogenesis of human retinal *** identified human TRPM1 gene mutations in congenital stationary night blindness(CSNB) *** retinopathy(PR),including cancer-associated retinopathy(CAR) and melanoma-associated retinopathy(MAR),is a progressive retinal disease caused by antibodies generated against neoplasms not associated with the *** several autoantibodies against retinal antigens have been identified,there has been no known autoantibody reacting specifically against bipolar cell antigens in the sera of patients with *** recently found that TRPM1 is one of the autoantigens targeted by autoantibodies in patients with CAR or MAR associated with retinal ON bipolar cell ***,our results suggest that TRPM1 plays an

关键词： TRPMl channel bipolar cell night blindness cancer-associated retinopathy

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