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Auto-cortex of crystalline lens-induced iris neovascularization

International Journal of Ophthalmology(English edition) 2012年第1期5卷 23-27页

作者： Lin Liu, Wen-Xin Zhang Guangzhou General Hospital of Guangzhou Military Command Guangzhou 510010 Guangdong Province China Zhongshan Ophthalmic Center Sun Yat-sen University Guangzhou 510060 Guangdong Province China

AIM:To investigate auto-cortex of crystalline lens induced iris neovascularization (INV). METHODS: Thirty-six eyes of 36 guinea-pigs were included and divided into three groups randomly in this cohort study. Group A: the right lens nucleus was extracted and the remaining cortical lens material was aspirated thoroughly.. Group B: the lens was removed and 30 mu L precipitated lens cortex was injected into the anterior chamber again. Group C: aspirated the lens cortex of the left eyes and inject them into the right anterior chambers about 10 mu L. Clinical changes were followed by slit-lamp examination and photograph. The eye balls were enucleated at the day of 2, 4, 7, 11, 13, 17 after operation. HE was used to detect the pathological changes. ' RESULTS:Group A:INV had not been observed until the end of empirical study. The stromal layer contained thick wall vessels, without expansion. Group B: All eyes developed INV. Postoperative (po) 7 days; the eyes developed intense and extensive INV. The vessels of iris expanded remarkably and neovascularization was observed erupting from it's lateral wall and stretching towards the anterior surface. Poll days, INV regressed gradually after lens cortex had been absorbed. Group C: Po four (4) days, new blood vessels liking red line were presented on the anterior surface of the iris and they were not obvious. CONCLUSION: Anterior chamber inside lens coriaceous can induce iris new blood vessels.

关键词： iris new vessels crystallins

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