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Determination of Methadone and Eight new psychoactive substances in Hair Samples by Gas Chromatography/Mass Spectrometry

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Journal of Forensic Science and Medicine 2018年第4期4卷 184-191页

作者： Luca Anzillotti Luca Cald Marianna Giacalone Antonio Banchini Rossana Cecchi Department of Medicine and Surgery Institute of Legal MedicineUniversity of ParmaParmaItaly

Many new psychoactive substances(NPSs)with different chemical structures have emerged in the illicit drug market in the last *** present work was aimed at the development of a simple method in gas chromatography/mass spectrometry(MS)for the determination of NPS of different classes,the use of cannabinoids,and,at the same time,the evaluation of methadone therapy in hair matrix,within our routine analysis control for methadone treatment or from autopsy *** determination of synthetic cannabinoids and methadone therapy used an extraction method based on incubation in concentrated sodium hydroxide(NaOH)solution,providing a dissolution of the keratin *** described method was applied on 15 authentic specimens from our cases:five showed the presence of methadone and 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine(EDDP).The described method can be useful not only in the forensic investigation of NPS-related addiction histories but also in epidemiological and retrospective studies on the spread of NPS among specific safety-sensitive social *** GC instrument was an Agilent 7820A(Agilent Technologies,Santa Clara,CA,USA),and the detection system was an Agilent 5977B single quadrupole MS operating in selective ion monitoring *** parameters such as limit of detections(LODs),limit of quantifications(LOQs),repeatability,accuracy,and linearity were satisfactory for its application on real ***,LOQs,2?2,%CY standard deviation,and the mean concentration for the analyzed compounds are reported in Table *** and repeatability were acceptable for all the analytes at their respective *** experiments varied from 58.3%to 103.0%,thus allowing the application on authentic *** described method can be useful not only in the forensic investigation ofNPS-related addiction histories but also in epidemiological and retrospective studies on the spread of NPS among specific safety-sensitive social workers,such as drivers.

关键词： Drugs of abuse forensic gas chromatography/mass spectrometry hair new psychoactive substance toxicology

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