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Neuroprotective and neuroregenerative potential of pharmacologically-induced hypothermia with D-alanine D-leucine enkephalin in brain injury

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Neural Regeneration Research 2018年第12期13卷 2029-2037页

作者： M.Grant Liska Marci G.Crowley Julian P.Tuazon Cesar V.Borlongan Center of Excellence for Aging and Brain Repair University of South Florida College of Medicine

neurovascular disorders, such as traumatic brain injury and stroke, persist as leading causes of death and disability - thus, the search for novel therapeutic approaches for these disorders continues. Many hurdles have hindered the translation of effective therapies for traumatic brain injury and stroke primarily because of the inherent complexity of neuropathologies and an inability of current treatment approaches to adapt to the unique cell death pathways that accompany the disorder symptoms. Indeed, developing potent treatments for brain injury that incorporate dynamic and multiple disorder-engaging therapeutic targets are likely to produce more effective outcomes than traditional drugs. The therapeutic use of hypothermia presents a promising option which may fit these criteria. While regulated temperature reduction has displayed great promise in preclinical studies of brain injury, clinical trials have been far less consistent and associated with adverse effects, especially when hypothermia is pursued via systemic cooling. Accordingly, devising better methods of inducing hypothermia may facilitate the entry of this treatment modality into the clinic. The use of the delta opioid peptide D-alanine D-leucine enkephalin（DADLE） to pharmacologically induce temperature reduction may offer a potent alternative, as DADLE displays both the ability to cause temperature reduction and to confer a broad profile of other neuroprotective and neuroregenerative processes. This review explores the prospect of DADLE-mediated hypothermia to treat neurovascular brain injuries, emphasizing the translational steps necessary for its clinical translation.

关键词： stroke traumatic brian injury neurodegeneration temperature management regenerative medicine delta opioids metabolic suppression cerebrovascular disease neurovascular disease

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Expression profiles of long noncoding RNAs in retinopathy of prematurity

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Neural Regeneration Research 2020年第10期15卷 1962-1968页

作者： Yue Wang Xue Wang Yuan Ma Yue-Xia Wang Yu Di Department of Ophthalmology Shengjing Hospital of China Medical University

Long noncoding RNA(lncRNA)regulates the proliferation and migration of human retinal endothelial cells,as well as retinal neovascularization in diabetic *** on similarities between the pathogenesis of retinopathy of prematurity(ROP)and diabetic retinopathy,lncRNA may also play a role in ***-day-old mice were administered 75±2% oxygen for 5 days and normoxic air for another 5 days to establish a ROP *** of lncRNA and mRNA in the retinal tissue of mice was detected by high-throughput sequencing technology,and biological functions of the resulted differentially expressed RNAs were evaluated by Gene Ontology and Kyoto Encyclopedia of Genes and Genomes *** results showed that compared with the control group,57 lncRNAs were differentially expressed,including 43 upregulated and 14 downregulated,in the retinal tissue of ROP *** with control mice,42 mRNAs were differentially expressed in the retinal tissue of ROP mice,including 24 upregulated and 18 downregulated *** expressed genes were involved in ocular development and related metabolic *** differentially expressed lncRNAs may regulate ROP in mice via microRNAs and multiple signaling *** results revealed that these differentially expressed lncRNAs may be therapeutic targets for ROP *** study was approved by the Medical Ethics Committee of Shengjing Hospital of China Medical University on February 25,2016(approval No.2016PS074K).

关键词： bioinformatics gene therapy long noncoding RNA microglial neurovascular disease optic neuropathy retinal development retinal neovascularization retinopathy of prematurity signaling pathways

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