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Syphilitic uveitis in HIV-positive patients: report of a case series, treatment outcomes, and comprehensive review of the literature

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International Journal of Ophthalmology(English edition) 2023年第8期16卷 1250-1259页

作者： Ning Xu Jia-Guo Yuan Qin-Jin Dai Chao Yuan Yan He Ting-Shuai Jiang Jie Zhu Guangzhou Twelfth People’s Hospital Guangzhou Medical UniversityGuangzhou 510620Guangdong ProvinceChina Guangzhou Eighth People’s Hospital Guangzhou Medical UniversityGuangzhou 510440Guangdong ProvinceChina Guangzhou Women and Children’s Medical Center Guangzhou Medical UniversityGuangzhou 510623Guangdong ProvinceChina Xijing Hospital Fourth Military Medical UniversityXi’an 710032Shaanxi ProvinceChina

AIM:To report the clinical characteristics,treatment and outcomes of active syphilitic uveitis in human immunodeficiency virus(HIV)positive patients and compare them with the previously published ***:Retrospective analysis of the case series from an infectious disease center in southern China was *** review of previously published cases of HIV positive syphilitic uveitis was conducted using the PubMed and Web of Science databases and the references listed in the identified ***:Twelve HIV positive patients with active syphilitic uveitis were *** were male,with age of 36.3y(range 27 to 53y).Five(41.7%)had a history of syphilis,and three of them had received anti-syphilis *** manifestations included corneal epithelial defect(13%),complicated cataract(17.4%),vitreous opacity(82.6%),optic disc edema(26.1%),macular edema(30.4%),neuro-retinitis(43.5%),and retinal hemorrhage(26.1%).After standardized syphilitic treatment,intraocular inflammation was reduced and vision improved in all *** literature review summarizes 105 previously reported cases of HIV positive syphilitic *** serum rapid plasma regain(RPR)titers may be associated with severe uveitis and poor *** with penicillin,ceftriaxone sodium,or penicillin plus benzylpenicillin instead of using benzylpenicillin alone can significantly improve bestcorrected visual acuity(BCVA)in HIV positive ocular syphilis ***:For HIV positive syphilitic uveitis patients,prompt diagnosis and appropriate treatment and follow-up are *** our series,the clinical manifestations are *** patients treated by penicillin G or long-acting penicillin before may still develop syphilitic *** who relapse after long-term penicillin treatment can still benefit from penicillin G.

关键词： syphilis uveitis human immunodeficiency virus neurosyphilis regimen literature review

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