检索结果-南通市图书馆

Science China(Life Sciences) 2021年第1期64卷 96-106页

作者： Zhijun Zhang Hongxing Zhang Chun-Ming Xie Meng Zhang Yachen Shi Ruize Song Xiang Lu Haisan Zhang Kun Li Bi Wang Yongfeng Yang Xianrui Li Jianli Zhu Yang Zhao Ti-Fei Yuan Georg Northoff Department of Neurology of Affiliated Zhongda Hospital Institute of Neuropsychiatry and Medical School of Southeast UniversityNanjing210009China Department of Psychology of Xinxiang Medical University Xinxiang453003China Second Affiliated Hospital of Xinxiang Medical University Xinxiang453002China Deaprtment of Biostatistics School of Public HealthNanjing Medical UniversityNanjing211166China Shanghai Mental Health Center Shanghai Jiaotong University School of MedicineShanghai200030China Mental Health Center and 7th Hospital Zhejiang University School of MedicineHangzhou310013China Royal Ottawa Mental Health Centre University of Ottawa Institute of Mental Health ResearchOttawaONK1Z 7K4Canada

To determine whether repetitive transcranial magnetic stimulation(rTMS)of the visual cortex(VC)provides effective and welltolerated treatment and whether magnetic resonance imaging(MRI)measures functional change of the VC as a biomarker of therapeutic effect in major depressive disorder(MDD),we performed a sham-controlled,double-blind,randomized,three-arm VC rTMS treatment study in 74 MDD *** rTMS(10 Hz,90%of resting motor threshold,1,600 pulses over20 min twice per day)was performed over the VC for five *** outcome was measured by Hamilton Depression Rating Scale(HAMD-24)at days 0,1,3,5 and after terminating rTMS,with follow-up at four *** was measured at days 0 *** individualized group exhibited the greatest change in HAMD-24 scores after VC rTMS for 5 days(F=5.53,P=0.005),which were maintained during follow-up period(F=4.22,P=0.016).All patients reported good *** in VC taskrelated functional MRI correlated with symptomatic reduction in the individualized *** reduced the initially abnormal increase in resting state functional connectivity from the VC to the pre/subgenual anterior cingulate cortex at day 5,especially in the individualized *** demonstrated therapeutic potential and good tolerance of VC rTMS in MDD patients,indicated by biomarkers of f MRI measurement.

关键词： major depressive disorder visual cortex functional magnetic resonance imaging repetitive transcranial magnetic stimulation neuronavigated individualized treatment

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