检索结果-南通市图书馆

High-frequency repetitive transcranial magnetic stimulation promotes neural stem cell proliferation after ischemic stroke

引用

Neural Regeneration Research 2024年第8期19卷 1772-1780页

作者： Jing Luo Yuan Feng Zhongqiu Hong Mingyu Yin Haiqing Zheng Liying Zhang Xiquan Hu Department of rehabilitation Medicine The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Hepatobiliary Surgery The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Prolife ration of neural stem cells is crucial for promoting neuronal regeneration and repairing cerebral infarction *** magnetic stimulation(TMS)has recently emerged as a tool for inducing endogenous neural stem cell regeneration,but its underlying mechanisms remain unclea r In this study,we found that repetitive TMS effectively promotes the proliferation of oxygen-glucose deprived neural stem ***,repetitive TMS reduced the volume of cerebral infa rction in a rat model of ischemic stro ke caused by middle cerebral artery occlusion,im p roved rat cognitive function,and promoted the proliferation of neural stem cells in the ischemic ***-sequencing found that repetitive TMS activated the Wnt signaling pathway in the ischemic penumbra of rats with cerebral ***,PCR analysis revealed that repetitive TMS promoted AKT phosphorylation,leading to an increase in mRNA levels of cell cycle-related proteins such as Cdk2 and *** effect was also associated with activation of the glycogen synthase kinase 3β/β-catenin signaling pathway,which ultimately promotes the prolife ration of neural stem ***,we validated the effect of repetitive TMS on AKT *** found that repetitive TMS promoted Ca2+influx into neural stem cells by activating the P2 calcium channel/calmodulin pathway,thereby promoting AKT phosphorylation and activating the glycogen synthase kinase 3β/β-catenin *** findings indicate that repetitive TMS can promote the proliferation of endogenous neural stem cells through a Ca2+influx-dependent phosphorylated AKT/glycogen synthase kinase 3β/β-catenin signaling *** study has produced pioneering res ults on the intrinsic mechanism of repetitive TMS to promote neural function recove ry after ischemic stro *** results provide a stro ng scientific foundation for the clinical application of repetitive ***,repetitive TMS treatment may not only be an efficient an

关键词： AKT/β-catenin signaling brain stimulation Ca2+influx cell proliferation ischemic stroke middle cerebral artery occlusion neural stem cells neurological rehabilitation repetitive transcranial magnetic stimulation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

An electroencephalography-based human-machine interface combined with contralateral C7 transfer in the treatment of brachial plexus injury

引用

Neural Regeneration Research 2022年第12期17卷 2600-2605页

作者： Meng Zhang Ci Li Song-Yang Liu Feng-Shi Zhang Pei-Xun Zhang Department of Orthopedics and Trauma Peking University People’s HospitalBeijingChina Key Laboratory of Trauma and Neural Regeneration Peking UniversityBeijingChina National Center for Trauma Medicine BeijingChina

Transferring the contralateral C7 nerve root to the median or radial nerve has become an important means of repairing brachial plexus nerve ***,outcomes have been ***(EEG)-based human-machine interfaces have achieved promising results in promoting neurological recovery by controlling a distal exoskeleton to perform functional limb exercises early after nerve injury,which maintains target muscle activity and promotes the neurological rehabilitation *** review summarizes the progress of research in EEG-based human-machine interface combined with contralateral C7 transfer repair of brachial plexus nerve *** transfer may result in loss of nerve function in the donor area,so only nerves with minimal impact on the donor area,such as the C7 nerve,should be selected as the *** tendon transfer does not fully restore optimal joint function,so multiple functions often need to be reestablished *** with traditional manual rehabilitation,EEG-based human-machine interfaces have the potential to maximize patient initiative and promote nerve regeneration and cortical remodeling,which facilitates neurological *** the early stages of brachial plexus injury treatment,the use of an EEG-based human-machine interface combined with contralateral C7 transfer can facilitate postoperative neurological recovery by making full use of the brain’s computational capabilities and actively controlling functional exercise with the aid of external *** can also prevent disuse atrophy of muscles and target organs and maintain neuromuscular junction *** cortical remodeling is also particularly important for neurological recovery after contralateral C7 *** studies are needed to investigate the mechanism by which early movement delays neuromuscular junction damage and promotes cortical *** this mechanism should help guide the development of neurolog

关键词： arm injuries brachial plexus brain-computer interfaces nerve transfer nerve regeneration nerve tissue neurofeedback neurological rehabilitation user-computer interface

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Tongguan Liqiao acupuncture therapy improves dysphagia after brainstem stroke

引用

Neural Regeneration Research 2016年第2期11卷 285-291页

作者： Chun-hong Zhang Jin-ling Bian Zhi-hong Meng Li-na Meng Xue-song Ren Zhi-lin Wang Xiao-yan Guo Xue-min Shi Department of Acupuncture and Moxibustion the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Department of Acupuncture and Moxibustion Tianjin University of Traditional Chinese Medicine

Tongguan Liqiao acupuncture therapy has been shown to effectively treat dysphagia after stroke-based pseudobulbar paralysis. We presumed that this therapy would be effective for dysphagia after bulbar paralysis in patients with brainstem infarction. Sixty-four patients with dysphagia following brainstem infarction were recruited and divided into a medulla oblongata infarction group（n = 22）, a midbrain and pons infarction group（n = 16）, and a multiple cerebral infarction group（n = 26） according to their magnetic resonance imaging results. All patients received Tongguan Liqiao acupuncture for 28 days. The main acupoints were Neiguan（PC6）, Renzhong（DU26）, Sanyinjiao（SP6）, Fengchi（GB20）, Wangu（GB12）, and Yifeng（SJ17）. Furthermore, the posterior pharyngeal wall was pricked. Before and after treatment, patient swallowing functions were evaluated with the Kubota Water Test, Fujishima Ichiro Rating Scale, and the Standard Swallowing Assessment. The Barthel Index was also used to evaluate their quality of life. Results showed that after 28 days of treatment, scores on the Kubota Water Test and Standard Swallowing Assessment had decreased, but scores on the Fujishima Ichiro Rating Scale and Barthel Index had increased in each group. The total efficacy rate was 92.2% after treatment, and was most obvious in patients with medulla oblongata infarction（95.9%）. These findings suggest that Tongguan Liqiao acupuncture therapy can repair the connection of upper motor neurons to the medulla oblongata motor nucleus, promote the recovery of brainstem infarction, and improve patient＇s swallowing ability and quality of life.

关键词： nerve regeneration traditional Chinese medicine acupuncture stroke bulbar palsy brain infarction swallowing disorder dysphagia acupoints neurological rehabilitation neural regeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mechanism of Kinect-based virtual reality training for motor functional recovery of upper limbs after subacute stroke

引用

Neural Regeneration Research 2013年第31期8卷 2904-2913页

作者： Xiao Bao Yurong Mao Qiang Lin Yunhai Qiu Shaozhen Chen Le Li Ryan S.Cates Shufeng Zhou Dongfeng Huang Department of rehabilitation Medicine the First Affiliated Hospital Sun Yat-sen University Key Laboratory of Health Informatics of Chinese Academy of Sciences Shenzhen Institutes of Advanced Technology Department of Pharmaceutical Sciences College of Pharmacy University of South Florida

The Kinect-based virtual reality system for the Xbox 360 enables users to control and interact with the game console without the need to touch a game controller, and provides rehabilitation training for stroke patients with lower limb dysfunctions. However, the underlying mechanism remains un- clear. In this study, 18 healthy subjects and five patients after subacute stroke were included. The five patients were scanned using functional MRI prior to training, 3 weeks after training and at a 12-week follow-up, and then compared with healthy subjects. The FugI-Meyer Assessment and Wolf Motor Function Test scores of the hemiplegic upper limbs of stroke patients were significantly increased 3 weeks after training and at the 12-week follow-up. Functional MRI results showed that contralateral primary sensorimotor cortex was activated after Kinect-based virtual reality training in the stroke patients compared with the healthy subjects. Contralateral primary sensorimotor cortex, the bilateral supplementary motor area and the ipsilateral cerebellum were also activated during hand-clenching in all 18 healthy subjects. Our findings indicate that Kinect-based virtual reality training could promote the recovery of upper limb motor function in subacute stroke patients, and brain reorganization by Kinect-based virtual reality training may be linked to the contralateral sen- sorimotor cortex.

关键词： neural regeneration neurological rehabilitation rehabilitation training neural plasticity virtual reality functional MRI stroke Kinect-based virtual reality training upper limb cerebral cortex brain activation region of interest grants-supported paper neuroregeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The Application and Development of Music Therapy in rehabilitation Medicine

引用

Journal of Contemporary Educational Research 2024年第7期8卷 283-289页

作者： Bingze Du Tong Sun Kangwon National University ChuncheonGangwon-do24341Republic of Korea

Music therapy,as an ancient and continually evolving therapeutic approach,has demonstrated unique effects and extensive potential applications in the field of rehabilitation *** paper first explores the physiological and psychological impacts of music and theoretical models of its therapeutic *** further details the specific applications of music therapy in neurological rehabilitation,motor function recovery,psychological and emotional adjustment,and chronic disease and pain *** article also investigates the prospects of integrating music therapy with modern technologies such as virtual reality and artificial intelligence and emphasizes the importance of interdisciplinary collaboration and policy support in advancing this *** comprehensive analysis,the paper identifies future development directions and research needs for music therapy in rehabilitation medicine.

关键词： Music therapy rehabilitation medicine neurological rehabilitation Emotional regulation Interdisciplinary collaboration

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effectiveness of the A3 robot on lower extremity motor function in stroke patients:A prospective,randomized controlled trial

引用

World Journal of Clinical Cases 2024年第24期12卷 5523-5533页

作者： Lin-Jian Zhang Xin Wen Yang Peng Wei Hu Hui Liao Zi-Cai Liu Hui-Yu Liu Department of rehabilitation Medicine Yuebei People's HospitalShaoguan 512000Guangdong ProvinceChina Department of rehabilitation Medicine Shaoguan First People's HospitalShaoguan 512000Guangdong ProvinceChina Department of rehabilitation Medicine Yuebei Second People's HospitalShaoguan 512026Guangdong ProvinceChina

BACKGROUND The results of existing lower extremity robotics studies are conflicting,and few relevant clinical trials have examined short-term *** addition,most of the outcome indicators in existing studies are scales,which are not objective *** used the combination of objective instrument measurement and scale to explore the short-term efficacy of the lower limb A3 robot,to provide a clinical *** To investigate the improvement of lower limb walking ability and balance in stroke treated by A3 lower limb *** Sixty stroke patients were recruited prospectively in a hospital and randomized into the A3 group and the control *** received 30 min of A3 robotics training and 30 min of floor walking training in addition to 30 min of regular rehabilitation *** training was performed five times a week,once a day,for 2 *** t-test or non-parametric test was used to compare the threedimensional gait parameters and balance between the two groups before and after *** The scores of basic activities of daily living,Stroke-Specific Quality of Life Scale,FM balance meter,Fugl-Meyer Assessment scores,Rivermead Mobility Index,Stride speed,Stride length,and Time Up and Go test in the two groups were significantly better than before treatment(19.29±12.15 vs 3.52±4.34;22.57±17.99 vs 4.07±2.51;1.21±0.83 vs 0.18±0.40;3.50±3.80 vs 0.96±2.08;2.07±1.21 vs 0.41±0.57;0.89±0.63 vs 0.11±0.32;12.38±9.00 vs 2.80±3.43;18.84±11.24 vs 3.80±10.83;45.12±69.41 vs 8.41±10.20;29.45±16.62 vs 8.68±10.74;P<0.05).All outcome indicators were significantly better in the A3 group than in the control group,except the area of the balance *** For the short-term treatment of patients with subacute stroke,the addition of A3 robotic walking training to conventional physiotherapy appears to be more effective than the addition of ground-based walking training.

关键词： Stroke Robotics Gait Robot-assisted gait training neurological rehabilitation Walking training

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Building up Systematic Client-Centred Data as a Base for Clinical Outcome within Outpatient Neurorehabilitation

引用

Open Journal of Therapy and rehabilitation 2016年第1期4卷 10-21页

作者： Jessica Vollertsen Kersti Samuelsson Department of rehabilitation and Department of Medical and Health Sciences Link&ouml ping University Motala Sweden Department of Social and Welfare Studies Link&ouml ping University Norrk&ouml ping Sweden Department of rehabilitation Medicine and Department of Medicine and Health Sciences Link&ouml ping University Link&ouml ping Sweden

Objective: This study describes the development and use of a specific database supporting personnel within outpatient neurological rehabilitation to reflect on existing interventions and improve future rehabilitation. Methods: Five outpatient rehabilitation centres in one county council in Sweden were involved in developing and implementing a systematic data collection template within the existing digital medical record system. Data were collected to get more information on the effects of outpatient stroke rehabilitation in patients who received rehabilitation the first year after a stroke (ICD-I64) and patients who received further rehabilitation 1 year or more after a stroke (ICD-I69). Data analysis included evaluation of balance, movement, activity/participation, health-related quality of life, and self-rated health. Results: The ICD-I64 group had positive results after treatment (p rehabilitation interventions.

关键词： neurological rehabilitation Occupational Therapy Quality Improvement Stroke

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A new portable multifunctional experimental device for rat neurobehavioral test.

A new portable multifunctional experimental device for rat n...

引用

浙江省神经科学学会-神经外科分会成立大会&2015钱江神经外科高峰论坛暨高血压脑出血诊治新进展学习班

作者： Jian Shi Shenglong Lai Hong Shen Department of Neurosurgery 2nd Affiliated HospitalCollege of MedicineZhejiang University

Background Available neurobehavioral devices had been designed to confirm different neurological abnormalities of laboratorial *** they can be applied effectively except some unresolved disadvantages,such as complex structure,costly price,difficulty for carrying,and only one kind of trial can be *** Method We reviewed some existent rat neurobehavioral trial projects,then designed and created a set of portable multifunctional *** According installation and geometrical change of this wooden equipment,five different trials were able to be practiced,which are Beam Walking Trial for locomotor function,Beam Balance Trial for motor cortical function,Slope Trial for posterior limb function,Open Field Activity Assay for hippocampal or striatal/cortical function and Corner Turn Test designed for memory reflection or action,evaluate the systemized neural function for experimental *** with Existing Method(s)Compared with Morris Water Maze and other neurobehavioral device,This invented device had some advantage,it could be folded and stored,the total weight is 3.6kg so that it could be conveniently carried;its cost was very lower,and was easy to copy;it was multifunctional,portable and *** could be assembled for five different trials in five minutes;it was able to evaluate laboratory rats complete neurobehavioral functions by five kinds of behavioral *** This whole device was designed with facilitation,multifunctional,easy repeat and portable *** integrate the various experimental data by moving this device instead of rats’ migration,the diversified neurobehavioral function of trial rats could be evaluated.

关键词： Neurobehavioral trial Rat neurological rehabilitation

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Long-term efficacy of extracorporeal shock wave therapy on lower limb post-stroke spasticity: a systematic review and meta-analysis of randomized controlled trials

引用

中华物理医学与康复杂志 2022年第5期44卷 401-401页

Objectives The purpose of this systematic review and meta-analysis is to evaluate the long-term efficacy of Extracorporeal Shock Wave Therapy (ESWT) on reducing lower limb post-stroke spasticity in *** A systematic electronic search of PubMed/ MEDLINE, Physiotherapy Evidence Database (PEDro), Scopus, Ovid MEDLINE(R), and search engine of Google Scholar was performed. Publications that ranged from January 2010 to August 2020, published in English, French, Spanish, Portuguese, and Italian language and available as full texts were eligible for inclusion and they were searched without any restrictions of country. The study was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines and followed the recommendations of the Cochrane Handbook for Systematic Reviews of Interventions. Two authors screened the references, extracted data, and assessed the risk of bias. The primary outcome was spasticity grade mainly assessed by the Modified Ashworth Scale (MAS). Secondary outcomes were passive range of motion (PROM), pain intensity, electrophysiological parameters, gait assessment, and adverse *** A total of seven recent randomized controlled trials (RCTs) were included in the systematic review and meta-analysis, and a beneficial effect on spasticity was found. The high level of evidence presented in this paper showed that ESWT ameliorates spasticity considering the parameters: MAS: standardized mean difference (SMD)=0.53;95% confidence interval (95% CI): (0.07-0.99);Modified Tardieu Scale (MTS): SMD=0.56;95% CI: (0.01-1.12);Visual Analogue Scale (VAS): SMD=0.35;95% CI: (-0.21-0.91);PROM: SMD=0.69;95% CI: (0.20-1.19).Conclusions ESWT presented long-term efficacy on lower limb post-stroke spasticity, reduced pain intensity, and increased range of motion. The effect of this novel and non-invasive therapy was significant and the intervention did not present adverse events, proving a satisfactory safety

关键词： extracorporeal shock wave therapy hemiplegia neurological rehabilitation spasticity stroke

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：