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Efficacy of chitosan and sodium alginate scaffolds for repair of spinal cord injury in rats

Neural Regeneration Research 2018年第3期13卷 502-509页

作者： Zi-ang Yao Feng-jia Chen hong-li Cui Tong Lin Na Guo hai-ge Wu School of Life Science and Technology Dalian University

Spinal cord injury results in the loss of motor and sensory pathways and spontaneous regeneration of adult mammalian spinal cord neurons is limited. Chitosan and sodium alginate have good biocompatibility, biodegradability, and are suitable to assist the recovery of damaged tissues, such as skin, bone and nerve. Chitosan scaffolds, sodium alginate scaffolds and chitosan-sodium alginate scaffolds were separately transplanted into rats with spinal cord hemisection. Basso-Beattie-Bresnahan locomotor rating scale scores and electrophysiological results showed that chitosan scaffolds promoted recovery of locomotor capacity and nerve transduction of the experimental *** days after surgery, chitosan scaffolds retained the original shape of the spinal cord. Compared with sodium alginate scaffolds- and chitosan-sodium alginate scaffolds-transplanted rats, more neurofilament-h-immunoreactive cells （regenerating nerve fibers） and less glial fibrillary acidic protein-immunoreactive cells （astrocytic scar tissue） were observed at the injury site of experimental rats in chitosan scaffold-transplanted rats. Due to the fast degradation rate of sodium alginate, sodium alginate scaffolds and composite material scaffolds did not have a supporting and bridging effect on the damaged tissue. Above all, compared with sodium alginate and composite material scaffolds, chitosan had better biocompatibility, could promote the regeneration of nerve fibers and prevent the formation of scar tissue,and as such, is more suitable to help the repair of spinal cord injury.

关键词： nerve regeneration spinal cord injury chitosan sodium alginate functional recovery scaffold neurofilament-h glial fibrillary acidic protein scar tissue locomotor capacity neural regeneration

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Progesterone modulates m TOR in the hippocampus of mice after traumatic brain injury

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Neural Regeneration Research 2018年第3期13卷 434-439页

作者： Richard Justin Garling Lora Talley Watts Shane Sprague Murat Digicaylioglu Department of Neurosurgery Wayne State University Detroit MI USA School of Medicine The University of Texas Health Science Center at San Antonio San Antonio TX USA Department of Neurosurgery The University of Texas Health Science Center at San Antonio San Antonio TX USA

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Nerve regeneration factor promotes nerve regeneration in rat

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Progress in Natural Science:Materials International 2006年第12期16卷 1281-1287页

作者： ZhANG Qi, LIU Mei, ZhOU Mingming and DING Fei**(Key Laboratory of Neuroregeneration, Nantong University, Nantong 226001, China ) Key Laboratory of Neuroregeneration Nantong University Nantong 226001 China

Nerve regeneration factor (NRF) extracted from an oral liquid of traditional Chinese medicine, as a nerve growth decoction has been reported by previous studies to exert effects of promoting nerve growth and preventing neuron apoptosis. For new insights into the function of NRF on primary cultured neurons, we investigated the neurite outgrowth in cultured rat dorsal root ganglion (DRG) explant treated with NRF by immunofluorescence and the gene and protein expressions of neurofilament-h(NF-h) and growth associated protein 43 (GAP43) in the cultured rat DRG neurons by real-time quantitative RT-PCR and Western blotting, respectively. In addition, we used a rat model of sciatic nerve crush to evaluate the effect of NRF on regeneration of injured sciatic nerve by a combination of walk track analysis, electrophysiological and histological assessments. The in vitro experiments indicated that NRF promoted the neurite growth of DRGs and the expression of NF-h and GAP43 at mRNA and protein levels in DRG neurons, and in vivo experiments showed that NRF improved peripheral nerve regeneration and functional recovery.

关键词： nerve regeneration factor dorsal root ganglion sciatic nerve crush injury neurofilament-h growth associated protein 43.

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