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Quantitative ultrastucture analysis of neuroendocrine cells of gastric mucosa on normal and pathological conditions

World Journal of Gastroenterology 1996年第3期2卷 155-157页

作者：虞积耀 D'Adda T 海军总医院病理科意大利Parma大学

AIMS To study the quantitative ultrastucture of neu- roendocrine cells of gastric mucosa on normal anc pathological conditions including the duodenal ulcer (DU) and Zollinger-Ellison syndrome (ZES). METHODS The neuroendocrine cells of the gastric mucosa of eight normal subjects,six patients with DU and five patients with ZES were quantitatively investi- gated with electro microscope and ultrastructure image analyzer. RESULTS The volume density of neuroendocrine cells in DU was 1.3% and 0.8% (vs 1.6% and 0.9%,P>0.05) in gastric antrum and corpus respectively. In antrum,G cells was of 65% (Pcells decreased in cell density (3% vs 9.5%) and in number of cell per unit area (Pcells increased (49% vs 30%,Pcells and EC cells decreasec (2% Pcells in corpus decreased in cell density (4% vs 22%,Pcells also decreased (11% vs 24%,Pcells increased (65% vs 30%,Pcells present some changes. Incresed gastrin in DU and ZES patients may be caused by the decrease of D cells and somatostatin secretion.

关键词： gastric mucosa/pathology neuroendocrine cells duodenal ulcer Zollinger-Ellison syndrome

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Biological characteristics of breast carcinomas with neuroendocrine cell differentiation

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Chinese Medical Journal 2004年第10期117卷 1536-1540页

作者：姚根有周吉林赵仲生阮俊 Department of Pathology Medical School Zhejiang University Hangzhou 310031 China

Background The aim of this study was to investigate DNA content and expression of c-erbB-2, PS2, and prostate-specific antigen (PSA) proteins in breast carcinomas with neuroendocrine (NE) cell *** Chromogranin, c-erbB-2, PS2, and PSA in 131 samples of breast cancer were detected immunohistochemically. Classic Feulgen staining image analysis techniques were used to quantify DNA content in 81 of the breast cancer *** The c-erbB-2 positive rate in breast carcinoma samples containing neuroendocrine cells was 37.5% and the rate of high expression of c-erbB-2 (++ or +++) was 33.3%, both significantly lower than that in breast carcinomas without neuroendocrine cells (62.6% and 68.7%, respectively, Pneuroendocrine cells were 72.2% and 55.0%, respectively, both significantly higher than that in breast carcinoma samples without neuroendocrine cells (45.0% and 16.4%, respectively, P 5c aneuploidy cells, and rate of aneuploidy among cells were all lower than that in NE (-) breast carcinomas (Pneuroendocrine differentiation have a lower rate of malignancy. neuroendocrine differentiation could serve as a prognostic marker in clinical practice.

关键词： breast cancer neuroendocrine cells differentiation

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