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世界临床病例杂志 2017年第3期5卷 82-92页

作者： Dennis A Bloomfield Alex Park Richmond University Medical Center

There is arguably no less understood or more intriguing problem in hypertension that the"white coat"condition,the standard concept of which is significantly blood pressure reading obtained by medical personnel of authoritative standing than that obtained by more junior and less authoritative personnel and by the patients *** hospital-initiated ambulatory blood pressure monitoring,the while effect manifests as initial and ending pressure elevations,and,in treated patients,a low daytime *** effect is essentially *** diastolic white coat hypertension appears to be exceedingly *** the basis of the studies,we believe that the white coat phenomenon is a common,periodic,neuro-endocrine reflex conditioned by anticipation of having the blood pressure taken and the fear of what this measurement may indicate concerning future *** does not change with time,or with prolonged association with the physician,particularly with advancing years,it may be superimposed upon essential hypertension,and in patients receiving hypertensive medication,blunting of the nighttime dip,which occurs in about half the patients,may be a compensatory mechanisms,rather than an indication of cardiovascular *** than the blunted dip,the morning surge or the widened pulse pressure,cardiovascular risk appears to be related to elevation of the average night time pressure.

关键词： White coat Ambulatory blood pressure Triggers Hypertension neuro-endocrine reflex Nighttime dip Morning surge Conditioned reflex

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neuroimaging and neuroendocrine insights into foodcravings and appetite interventions in obesity

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Psychoradiology 2023年第1期3卷 95-106页

作者： Jin Huang Chen Wang Hang-Bin Zhang Hui Zheng Tao Huang Jian-Zhong Di Department of Metabolic&Bariatric Surgery Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai 200233China Shanghai Key Laboratory of Psychotic Disorders Brain Health InstituteNational Centre for Mental DisordersShanghai Mental Health CentreShanghai Jiao Tong Univ ersity Sc hool of MedicineShanghai 200030China Xuhui Health Care Commission Shanghai 200030China

This article reviews the previous studies on the distinction between food cravings and appetite,and how they are regulated by hor-mones and reflected in brain *** on existing research,food cravings are defined as individual preferences influenced by hormones and psychological factors,which differ from appetite,as they are not necessarily related to hunger or nutritional *** article also evaluates the neuroimaging findings about food cravings,and interventions to reduce food cravings,such as mindfulness training,alternative sweeteners,non-invasive brain stimulation techniques,cognitive-behavioral therapy,and imaginal retraining,and points out their advantages,disadvantages,and ***,the article delves into the potential future directions in the field,emphasizing the need for a neuroendocrine perspective,considerations for associated psychiatric disorders,innovative clinical interventions,and emerging therapeutic frontiers in obesity *** article outlines the neuro-endocrine basis of food cravings,including ghrelin,leptin,melanocortin,oxytocin,glucagon-like peptide-1,baclofen,and other hormones and their brain regions of *** article argues that food cravings are an important target for obesity,and more research is needed to explore their complex characteristics and mechanisms,and how to effectively interact with their neuro-endocrine *** article provides a new perspective and approach to the prevention and treatment of obesity.

关键词： food cravings fMRI appetite obesity neuro-endocrine

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Metastatic type 1 gastric carcinoid:A real threat or just a myth?

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World Journal of Gastroenterology 2013年第46期19卷 8687-8695页

作者： Simona Grozinsky-Glasberg Dimitrios Thomas Jonathan R Strosberg Ulrich-Frank Pape Stephan Felder Apostolos V Tsolakis Krystallenia I Alexandraki Merav Fraenkel Leonard Saiegh Petachia Reissman Gregory Kaltsas David J Gross neuroendocrine Tumor Unit Endocrinology and Metabolism ServiceDepartment of MedicineHadassah-Hebrew University Medical Center endocrine Unit Department of PathophysiologyNational University of Athens Moffitt Cancer Center Tampa Department of Internal Medicine Division of HepatologyGastroenterologyEndocrinology and MetabolismCharité Universit tsmedizin Department of Medical Sciences Section of Endocrine OncologyUppsala University Institute of Endocrinology Soroka Ben Gurion University Hospital Department of Surgery Shaare-Zedek Medical CenterThe Hebrew University School of Medicine

AIM:To describe disease characteristics and treatment modalities in a group of rare patients with metastatic gastric carcinoid type 1(GCA1).METHODS:Information on clinical,biochemical,radiological,histopathological findings,the extent of the disease,as well as the use of different therapeutic modalities and the long-term outcome were ***’data were assessed at presentation,and thereafter at 6 to 12 monthly intervals both clinically and biochemically,but also endoscopically and *** were evaluated for the presence of specific symptoms;the presence of autoimmune disorders and the presence of other gastrointestinal malignancies in other family members were also *** evaluation of response to treatment was defined using established WHO ***:We studied twenty consecutive patients with a mean age of 55.1 *** mean follow-up period was 83 *** patients had regional lymph node metastases and 8 patients had liver *** primary tumor mean diameter was 20.13±10.83mm(mean±SD).The mean Ki-67 index was 6.8%±11.2%.All but one patient underwent endoscopic or surgical excision of the *** disease was stable in all but 3 patients who had progressive liver *** patients remained alive during the follow-up ***:Metastatic GCA1 carries a good overall prognosis,being related to a tumor size of≥1 cm,an elevated Ki-67 index and high serum gastrin levels.

关键词： Metastatic gastric carcinoids Gastrin Chro-mogranin A Somatostatin analogues Stomach neuro-endocrine tumor

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