检索结果-南通市图书馆

Hierarchical platinum–iridium neural electrodes structured by femtosecond laser for superwicking interface and superior charge storage capacity

引用

Bio-Design and Manufacturing 2022年第1期5卷 163-173页

作者： Linze Li Changqing Jiang Luming Li National Engineering Laboratory for Neuromodulation School of Aerospace EngineeringTsinghua UniversityBeijing 100084China Precision Medicine and Healthcare Research Center Tsinghua-Berkeley Shenzhen InstituteTsinghua UniversityShenzhen 518071China IDG/McGovern Institute for Brain Research at Tsinghua University Beijing 100084China Institute of Epilepsy Beijing Institute for Brain DisordersBeijing 100093China

The interfacial performance of implanted neural electrodes is crucial for stimulation safety and the recording quality of neuronal *** paper proposes a novel surface architecture and optimization strategy for the platinum–iridium(Pt–Ir)electrode to optimize electrochemical performance and wettability.A series of surface micro/nano structures were fabricated on Pt–Ir electrodes with different combinations of four adjustable laser-processing ***,the electrodes were characterized by scanning electron microscopy,energy-dispersive X-ray spectroscopy,cyclic voltammetry,electrochemical impedance spectroscopy,and wetting *** results show that electrode performance strongly depends on the surface *** scanning overlap along with moderate pulse energy and the right number of pulses leads to enriched surface micro/nano structures and improved electrode *** raises the maximum charge storage capacity to 128.2 mC/cm^(2) and the interface capacitance of electrodes to 3.0×10^(4)μF/cm^(2) for the geometric area,compared with 4.6 mC/cm^(2) and 443.1μF/cm2,respectively,for the smooth Pt–Ir *** corresponding optimal results for the optically measured area are 111.8 mC/cm^(2) and 2.6×10^(4)μF/cm^(2),which indicate the contribution of fner structures to the ablation *** hierarchical structures formed by the femtosecond laser dramatically enhanced the wettability of the electrode interface,giving it superwicking properties.A wicking speed of approximately 80 mm/s was *** optimization strategy,leading to superior performance of the superwicking Pt–Ir interface,is promising for use in new neural electrodes.

关键词： Charge storage capacity Femtosecond laser Hierarchical structures neural electrodes Superwicking

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Polyurethane/poly(vinyl alcohol) hydrogel coating improves the cytocompatibility of neural electrodes

引用

neural Regeneration Research 2015年第12期10卷 2048-2053页

作者： Mei Li Hai-han Zhou Tao Li Cheng-yan Li Zhong-yuan Xia Yanwen Y.Duan Department of Anesthesiology Renmin Hospital of Wuhan University Institute of Molecular Science Shanxi University Department of Neurology Renmin Hospital of Wuhan University College of Chemistry and Molecular Sciences Wuhan University

neural electrodes,the core component of neural prostheses,are usually encapsulated in polydimethylsiloxane（PDMS）.However,PDMS can generate a tissue response after *** on the physicochemical properties and excellent biocompatibility of polyurethane（PU）and poly（vinyl alcohol）（PVA）when used as coating materials,we synthesized PU/PVA hydrogel coatings and coated the surface of PDMS using plasma treatment,and the cytocompatibility to rat pheochromocytoma（PC12）cells was *** adsorption tests indicated that the amount of protein adsorption onto the PDMS substrate was reduced by 92%after coating with the ***,the PC12 cells on the PU/PVA-coated PDMS showed higher cell density and longer and more numerous neurites than those on the uncoated *** results indicate that the PU/PVA hydrogel is cytocompatible and a promising coating material for neural electrodes to improve their biocompatibility.

关键词： nerve regeneration cerebral injury neural electrodes hydrogel coatings polyurethane polydimethylsiloxane poly(vinyl alcohol) cytocompatibility protein adsorption nerve growth factor mt pheochromocytoma cells synaptic differentiation neural regeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Platinum Wire Implants Coated with PEDOT/Carbon Nanotube Conducting Polymer Films in the Brain of Rats: A Histological Evaluation

引用

Journal of Wuhan University of Technology(Materials Science) 2012年第6期27卷 1053-1057页

作者：程璇 LI Chengyan RAO Li ZHOU Haihan 李涛段晏文 Department of Neurology Renmin Hospital of Wuhan University College of Chemistry and Molecular Sciences Wuhan University

Platinum （Pt） implants coated with poly （3, 4-ethylenedioxythiophene）/carbon nanotube （PEDOT/CNT） composite films were implanted into the brain of rats, and the brain response was evaluated 6 weeks after the implantation. The surface morphology of Pt implants with and without the PEDOT/CNT coating was studied using scanning electron microscopy （SEM）. After 6 weeks post-implantation, the expression of laminin （vascular endothelial marker） and neuronal nuclei （NeuN, neuronal marker） were evaluated by immnohistochemistry. It is revealed that the obvious improvements of the surface density of blood vessels and neurons aound the Pt implants with the coating, which were evidenced by laminin and NeuN staining in the zone within the distance of 150 μm to the implant interface. These results suggest the PEDOT/CNT composite films can improve the biocompatibility of the Pt electrodes while it is implanted in brain.

关键词： neural electrodes biocompatibility poly (3, 4-ethylenedioxythiophene) (PEDOT) carbon nanotube (CNT) laminin neuronal nuclei

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Biocompatibility of Implantable electrodes Coated with PVA Films in the Brain of Rats: a Histological Evaluation

引用

Journal of Wuhan University of Technology(Materials Science) 2009年第3期24卷 393-396页

作者：周琴李涛 Department of Neurology Renmin Hospital of Wuhan University

The biocompatibility of silicone rubber （SR） based electrodes coating with poly （vinyl alcohol）（PVA） films after implanted in the brain of rats was investigated. Twenty-two Wistar rats were used and implanted with SR electrodes and PVA/PAA films coated electrodes in left and right cerebral cortex respectively. After 4 and 8 weeks, the expression of glial fibrillary acidic protein （GFAP, a specific marker of astrocytes） and cluster of differentiation 68 （CD68, a specific marker of macrophages） were evaluated by immunohistochemistry. After 8 weeks, GFAP and CD68 expressions around PVA electrodes were significantly lower than those around SR electrodes in every stratified area （0-50 μm, 50-100 μm, 100 μm from further up to the electrode-tissue interface）. The resuits show that PVA coating can reduce the expressions of GFAP and CD68, suggesting the PVA coating can improve the biocompatibility of the SR while it is implanted in brain.

关键词： biocompatibility poly(vinyl alcohol)(PVA) neural electrodes glial fibrillary acidic protein cluster of differentiation 68

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：