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Scaffoldless tissue-engineered nerve conduit promotes peripheral nerve regeneration and functional recovery after tibial nerve injury in rats

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neural Regeneration Research 2017年第9期12卷 1529-1537页

作者： Aaron M.Adams Keith W.VanDusen Tatiana Y.Kostrominova Jacob P.Mertens Lisa M.Larkin Department of Molecular and Integrated Physiology University of Michigan Department of Anatomy and Cell Biology Indiana University School of Medicine Department of Biomedical Engineering University of Michigan

Damage to peripheral nerve tissue may cause loss of function in both the nerve and the targeted muscles it innervates. This study compared the repair capability of engineered nerve conduit （ENC）, engineered fibroblast conduit （EFC）, and autograft in a 10-mm tibial nerve gap. ENCs were fabricated utilizing primary fibroblasts and the nerve cells of rats on embryonic day 15 （E 15）. EFCs were fabricated utilizing primary fi- broblasts only. Following a 12-week recovery, nerve repair was assessed by measuring contractile properties in the medial gastrocnemius muscle, distal motor nerve conduction velocity in the lateral gastrocnemius, and histology of muscle and nerve. The autografts, ENCs and EFCs reestablished 96%, 87% and 84% of native distal motor nerve conduction velocity in the lateral gastrocnemius, 100%, 44% and 44% of native specific force of medical gastrocnemius, and 63%, 61% and 67% of native medial gastrocnemius mass, re- spectively. Histology of the repaired nerve revealed large axons in the autograft, larger but fewer axons in the ENC repair, and many smaller axons in the EFC repair. Muscle histology revealed similar muscle fiber cross-sectional areas among autograft, ENC and EFC repairs. In conclusion, both ENCs and EFCs promot- ed nerve regeneration in a 10-mm tibial nerve gap repair, suggesting that the El5 rat nerve cells may not be necessary for nerve regeneration, and EFC alone can suffice for peripheral nerve injury repair.

关键词： nerve regeneration peripheral nerve repair neural conduit tissue engineering fibroblasts neuralcells

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Mesenchymal stem cell treatment for peripheral nerve injury:a narrative review

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neural Regeneration Research 2021年第11期16卷 2170-2176页

作者： Rui-Cheng Zhang Wen-Qi Du Jing-Yuan Zhang Shao-Xia Yu Fang-Zhi Lu Hong-Mei Ding Yan-Bo Cheng Chao Ren De-Qin Geng Department of Neurology Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Human Anatomy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Neurosurgery The Affiliated Yantai Yuhuangding Hospital of Qingdao UniversityYantaiShandong ProvinceChina Department of Neurology The Affiliated Yantai Yuhuangding Hospital of Qingdao UniversityYantaiShandong ProvinceChina

Peripheral nerve injuries occur as the result of sudden trauma and lead to reduced quality of *** peripheral nervous system has an inherent capability to regenerate ***,peripheral nerve regeneration following injury is generally slow and incomplete that results in poor functional outcomes such as muscle *** conventional surgical procedures for peripheral nerve injuries present many benefits,there are still several limitations including scarring,difficult accessibility to donor nerve,neuroma formation and a need to sacrifice the autologous *** many years,other therapeutic approaches for peripheral nerve injuries have been explored,the most notable being the replacement of Schwann cells,the glial cells responsible for clearing out debris from the site of *** cultured Schwann cells to the injured sites showed great benefits in promoting axonal regeneration and functional ***,there are limited sources of Schwann cells for extraction and difficulties in culturing Schwann cells in ***,novel therapeutic avenues that offer maximum benefits for the treatment of peripheral nerve injuries should be *** review focused on strategies using mesenchymal stem cells to promote peripheral nerve regeneration including exosomes of mesenchymal stem cells,nerve engineering using the nerve guidance conduits containing mesenchymal stem cells,and genetically engineered mesenchymal stem *** present the current progress of mesenchymal stem cell treatment of peripheral nerve injuries.

关键词： axonal regeneration exosomes genetic engineering mesenchymal stem cells neural conduit peripheral nerve peripheral nerve injury peripheral nerve regeneration Schwann cells sudden trauma

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