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monocarboxylate transporter 4 plays a significant role in the neuroprotective mechanism of ischemic preconditioning in transient cerebral ischemia

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neural regeneration Research 2015年第10期10卷 1604-1611页

作者： Seongkweon Hong Ji Yun Ahn Geum-Sil Cho In Hye Kim Jeong Hwi Cho Ji Hyeon Ahn Joon Ha Park Moo-Ho Won Bai Hui Chen Bich-Na Shin Hyun-Jin Tae Seung Min Park Jun Hwi Cho Soo Young Choi Jae-Chul Lee Department of Surgery School of Medicine Kangwon National University Department of Emergency Medicine Sacred Heart Hospital College of Medicine Hallym University Department of Emergency Medicine School of Medicine Kangwon National University Department of Neuroscience College of Medicine Korea University Department of Neurobiology School of Medicine Kangwon National University Department of Physiology College of Medicine Hallym University Department of Biomedical Science Research Institute of Bioscience and Biotechnology Hallym University

monocarboxylate transporters（MCTs）, which carry monocarboxylates such as lactate across biological membranes, have been associated with cerebral ischemia/reperfusion process. In this study, we studied the effect of ischemic preconditioning（IPC） on MCT4 immunoreactivity after 5 minutes of transient cerebral ischemia in the gerbil. Animals were randomly designated to four groups（sham-operated group, ischemia only group, IPC ＋ sham-operated group and IPC ＋ ischemia group）. A serious loss of neuron was found in the stratum pyramidale of the hippocampal ca1 region（ca1）, not ca2/3, of the ischemia-only group at 5 days post-ischemia; however, in the IPC ＋ ischemia groups, neurons in the stratum pyramidale of the ca1 were well protected. Weak MCT4 immunoreactivity was found in the stratum pyramidale of the ca1 in the sham-operated group. MCT4 immunoreactivity in the stratum pyramidale began to decrease at 2 days post-ischemia and was hardly detected at 5 days post-ischemia; at this time point, MCT4 immunoreactivity was newly expressed in astrocytes. In the IPC ＋ sham-operated group, MCT4 immunoreactivity in the stratum pyramidale of the ca1 was increased compared with the sham-operated group, and, in the IPC ＋ ischemia group, MCT4 immunoreactivity was also increased in the stratum pyramidale compared with the ischemia only group. Briefly, present findings show that IPC apparently protected ca1 pyramidal neurons and increased or maintained MCT4 expression in the stratum pyramidale of the ca1 after transient cerebral ischemia. Our findings suggest that MCT4 appears to play a significant role in the neuroprotective mechanism of IPC in the gerbil with transient cerebral ischemia.

关键词： nerve regeneration monocarboxylate transporters ischemic preconditioning ischemia/ reperfusion injury hippocampus ca1 pyramidal neurons neural regeneration

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