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Effect of erythropoietin combined with hypothermia on serum tau protein levels and neurodevelopmental outcome in neonates with hypoxic-ischemic encephalopathy

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neural regeneration Research 2017年第10期12卷 1655-1663页

作者： Hong-yan Lv Su-jing Wu Qiu-li Wang Li-hong Yang Peng-shun Ren Bao-jun Qiao Zhi-ying Wang Jia-hong Li Xiu-ling Gu Lian-xiang Li Department of Neonatology Handan Maternal and Child Health Care HospitalHandanHebei ProvinceChina Department of Neonatal Pathology Handan Maternal and Child Health Care HospitalHandanHebei ProvinceChina Department of Children’s Rehabilitation Handan Maternal and Child Health Care HospitalHandanHebei ProvinceChina Department of neural Development and neural Pathology Hebei University of Engineering School of MedicineHandanHebei ProvinceChina

Although hypothermia therapy is effective to treat neonatal hypoxic-ischemic encephalopathy,many neonatal patients die or suffer from severe neurological *** is considered one of the most promising neuroprotective *** hypothesized that erythropoietin combined with hypothermia will improve efficacy of neonatal hypoxic-ischemic encephalopathy *** this study,41 neonates with moderate/severe hypoxic-ischemic encephalopathy were randomly divided into a control group（hypothermia alone for 72 hours,n = 20） and erythropoietin group（hypothermia ＋ erythropoietin 200 IU/kg for 10 days,n = 21）.Our results show that compared with the control group,serum tau protein levels were lower and neonatal behavioral neurological assessment scores higher in the erythropoietin group at 8 and 12 ***,neurodevelopmental outcome was similar between the two groups at 9 months of *** findings suggest that erythropoietin combined with hypothermia reduces serum tau protein levels and improves neonatal behavioral neurology outcome but does not affect long-term neurodevelopmental outcome.

关键词： nerve regeneration erythropoietin hypothermia hypoxic-ischemic encephalopathy neonate tau protein biomarkers prognosis neuroprotection neural regeneration

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