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International Journal of Oral Science 2011年第4期3卷 180-191页

作者： Song Fan Qiong-lan Tang Ying-jin Lin Wei-liang Chen Jin-song Li Zhi-quan Huang Zhao-hui Yang You-yuan Wang Da-ming Zhang Hui-jing Wang Eduardo Dias-Ribeiro Qiang Cai Lei Wang Department of Oral and Maxillofacial Surgery Sun Yet-Sen Memorial Hospital （Second Affiliated Hospital） of Sun Yat-Sen University Guangzhou 510120 China Department of Pathology Sun Yet-Sen Memorial Hospital （Second Affiliated Hospital） of Sun Yat-Sen University Guangzhou 510120 China Department of Neurology The First Affiliated Hospital of Guangzhou Medical College Guangzhou 510120 China Faculty of Dentistry University Center of Joao Pessoa Joao Pessoa 1602 Brazil

Oral squamous cell carcinoma （OSCC） has a high incidence of cervical micrometastases and sometimes metastasizes contralaterally because of the rich lymphatic intercommunications relative to submucosal plexus of oral cavity that freely communicate across the midline, and it can facilitate the spread of neoplastic cells to any area of the neck consequently. Clinical and histopathologic factors continue to provide predictive information to contralateral neck metastases （CLNM） in OSCC, which determine prophylactic and adjuvant treatments for an individual patient. This review describes the predictive value of clinical-histopathologic factors, which relate to primary tumor and cervical lymph nodes, and surgical dissection and adjuvant treatments. In addition, the indications for elective contralateral neck dissection and adjuvant radiotherapy （aRT） and strategies for follow-up are offered, which is strongly focused by clinicians to prevent later CLNM and poor prognosis subsequently.

关键词： oral squamous cell carcinoma lymph node metastasis contralateral neck metastasis neck dissection head and neck cancer

Metastasis to regional anatomies beyond the traditional neck dissections boundaries for oral cavity squamous cell carcinomas: A retrospective analysis with a focus on unconventional or neglected metastatic anatomic structures

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Metastasis to regional anatomies beyond the traditional neck...

2019第一届全国口腔颌面-头颈肿瘤学术大会——聚合引领、协同发展

作者：马春跃田卓炜胡镜宙上海交通大学医学院附属第九人民医院

Purpose/Background:The purpose of this study was to evaluate the incidence, risk factors and outcomes for salvage treatment of these previously surgically untreated regional lymph nodes metastases in oral cavity cancer patients with a specific focus on sublingual, buccinator and parotid anatomies. Materials and Methods:A retrospective analysis for locoregional recurrent patients with oral squamous cell carcinomas were performed retrospectively in four domestic hospitals from January 2008 to December 2018. All the included cases in this study met the inclusion criteria and received surgical retreatment for these previously surgically untreated regional metastases.

关键词： lingual buccinator parotid parapharyngeal lymph nodes neck dissection

Sternocleidomastoid flap for reconstruction of tongue small cell carcinoma: A case report

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World Journal of Surgical Procedures 2024年第2期14卷 8-14页

作者： Hendry Irawan Made Bagus Sastrapramaya Bharata Surgical Oncology Division Department of SurgeryMedical Faculty Universitas UdayanaDenpasar 80113BaliIndonesia General Surgery Resident Department of SurgeryMedical Faculty Universitas UdayanaProf.Dr.I.G.N.G.Ngoerah General HospitalDenpasar 80113BaliIndonesia

BACKGROUND The management of tongue carcinoma is excision and radical neck dissection followed with *** is a case report of a patient with tongue squamous cell carcinoma(SCC)who underwent the procedure with sternocleidomastoid(SCM)flap *** SUMMARY A 52-year-old woman without smoking history complained tongue ulcer since 3 years *** on the histopathological examination,the patient was diagnosed with T2N2M0 right tongue SCC and underwent wide excision of tumor;right mandibular;neck dissection and were reconstructed with SCM *** SCC of the tongue requires wide excision and dissection of the neck and mandible if infiltration into the surrounding lymph nodes has been *** SCM flap reconstruction could be used post-surgery.

关键词： Sternocleidomastoid flap neck dissection Mandibular dissection Squamous cell carcinoma of the tongue Case report

OCCULT CERVICAL METASTASIS OF SQUAMOUS CELL CARCINOMA OF TONGUE AMONG CN0 PATIENTS AND ITS TREATMENT

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Chinese Journal of Cancer Research 2005年第3期17卷 227-229页

作者：魏远坚胡顺广廖贵清郭海鹏林嘉旭邱月燕 Department of Stomatology Shantou Second People's Hospital Guanghua College of Stomatology Sun Yat-sen University Department of Head and neck Surgery Tumor Hospital Shantou University Department of Stomatology Shantou Center Hospital Department of Pathology Shantou Second People's Hospital

Objective： To explore the treatment of clinically negative neck （CN0） patients with squamous cell carcinoma of the tongue. Methods： 165 CN0 patients with squamous cell carcinoma of the tongue from 1985 to 2002 were investigated retrospectively. Parts of the patients staged at T1, T2 and T3 underwent resection of primary lesion followed by neck observation, and other patients staged above T2 or at T1 but without follow-up were treated with elective neck dissection （END）. All patients were followed up for more than 3 y or until their death. Results： Lymphatic metastasis was identified histologically after operation in 33 of 120 patients treated with END, and 9 of 45 patients treated with resection of primary lesion alone. The overall rate of occult lymphatic metastasis was 25.45%, which increased with the elevating of clinical T stage. The overall rate of neck uncontrolled death was 20.00% for observation group and 5.00% for END group, and significant difference was found between them （P〈0.05）. For T~ patients in the two groups, the rate of neck uncontrolled death was 7.71% and 4.00% respectively, and no significance was found between them （P〉0.05）. When stage T2 and T3 were considered as middle stage together, significant difference （P〈0.05） could be obtained between observation （70.00%） and END group （0%）. Conclusion： The occult metastasis rate of squamous cell carcinoma of tongue increases with the elevating of clinical stage, and elective neck dissection could be considered for NO patients staged over T2 to improve neck control and survival rate; and regional resection alone of primary lesion could be considered for T1N0 patients to improve quality of life if closely followed up is conducted.

关键词： Squamous cell carcinoma of the tongue Lymph node Occult metastasis neck dissection

Sentinel node biopsy guided neck management can improve survival of oral squamous cell carcinoma patients with clinically negative neck: a systematic review and network meta-analysis

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Sentinel node biopsy guided neck management can improve surv...

2019第一届全国口腔颌面-头颈肿瘤学术大会——聚合引领、协同发展

作者：曹钰彬李春洁李龙江四川大学华西口腔医院

Purpose/Background:The aim of this systematic review was to explore the feasibility of sentinel node biopsy(SNB) to determine the most appropriate neck management method in clinically neck negative(cN0) oral squamous cell carcinoma(OSCC) patients in an individual level, and to establish whether SNB guided neck management can benefit cN0 OSCC patients.

关键词： sentinel node biopsy mouth neoplasms neck dissection systematic review

Sentinel node biopsy guided neck management strategy in oral squamous cell carcinoma patients with clinically negative neck: a systematic review and meta-analysis

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Sentinel node biopsy guided neck management strategy in oral...

2020年全国口腔颌面-头颈肿瘤学术大会暨中华口腔医学会口腔颌面-头颈肿瘤专业委员会学术年会——创新超越、共赢未来

作者：曹钰彬门乙李春洁李龙江四川大学华西口腔医(学)院

Purpose/Background:Sentinel node biopsy(SNB) guided neck management strategy is a potentially optimal option for oral squamous cell carcinoma(OSCC) patients with clinically negative neck(cN0), which has not been extensively adopted. To explore the feasibility of SNB to determine the most appropriate neck management method in c N0 OSCC patients in an individual level, and to detect whether SNB guided neck management can benefit cN0 OSCC patients.

关键词： neck dissection

Diagnostic accuracy of MRI and PET/CT for neck staging prior to salvage total laryngectomy

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Journal of Cancer Metastasis and Treatment 2022年第1期8卷 1-14页

作者： Jonas Galli Roland Giger Olgun Elicin Martin Wartenberg Lukas Anschuetz Lluís Nisa Department of Otorhinolaryngology Head and Neck SurgeryInselspitalBern University Hospitaland University of BernBern 3010Switzerland Department of Radiation Oncology InselspitalBern University Hospitaland University of BernBern 3010Switzerland Institute of Pathology University of BernBern 3008Switzerland

Aim:Lymph node(LN)metastases are associated with poor outcomes in patients with recurrent larynx squamous cell carcinoma(LSCC).neck dissection(ND)is therefore commonly performed along with salvage total laryngectomy(STL).Here,we assess the rate of occult LN metastases and the diagnostic value of MRI and PET/CT for detecting them in recurrent ***:This retrospective study included patients with recurrent LSCC after primary(chemo)radiotherapy[(C)RT]who were re-staged by MRI and/or PET/CT and treated with STL and ND between 2004 and *** histopathology of ND samples was used as the reference ***:Forty-one patients were *** prevalence of occult metastases in MRI-negative and PET/CT-negative neck nodes was between 3.2%and 6.1%.Negative predictive values of neck node re-staging were 93.9%for MRI,96.8%for PET/CT,and 96.2%for MRI and PET/CT ***:Both MRI and PET/CT afforded good negative predictive values for nodal staging in patients with recurrent LSCC after(C)RT prior to *** selected patients,these radiological modalities,particularly PET/CT,could help to avoid unnecessary surgery to the neck and its associated morbidity.

关键词： Laryngeal squamous cell carcinoma recurrence salvage total laryngectomy re-staging neck dissection MRI PET/CT occult nodal metastasis

Occult cervical lymph node metastases in 100 consecutive patients with cNO tongue cancer

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Chinese Medical Journal 2008年第19期121卷 1871-1874页

作者： JIN Wu-long YE Wei-min ZHENG Jia-wei ZHOU Liang ZHU Han-guang ZHANG Zhi-yuan TIAN Jie Department of Head and neck Surgery Ear Nose and Throat Hospital School of Medicine Fudan University Shanghai 200031 China Department of Oral and Maxillofacial Surgery College of Stomatology Shanghai Ninth People's Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200011 China

Background Squamous cell carcinoma （SCC） of the tongue maxillofacial region. To provide clinical evidence for selective analyzing the characteristics and correlation of factors of occult with SCC of the tongue. is one of the most common cancers in the oral and neck dissection in management of cN0 patients by cervical lymph node metastases （OCLNM） in patients Methods From 2002 to 2006, 100 consecutive patients with SCC of the tongue were reviewed by analyzing the characteristics of OCLNM, diameter of the tumor, T classifications, depth of invasion, forms of growth, pathological grade and degree of differentiation. Results The rate of OCLNM in 100 patients with SCC of the tongue was 22%. The most common region with OCLNM was level Ⅱ in the ipsilateral neck, followed by levels Ⅰ and Ⅲ. There were 51.61% （16/31） of OCLNM in level Ⅱ and 87.10% （27/31） of OCLNM in levels Ⅰ-Ⅲ. There was no significant correlation between the diameter of tumor and OCLNM （P 〉0.05）. OCLNM was statistically significantly correlated with the depth of invasion, forms of growth, pathological grade and degree of differentiation （P 〈0.05）. The rate of occult metastases increased with the increased pathological grade, the decreased degree of differentiation and the increased depth of invasion. Conclusions The most common regions with OCLNM in cN0 patients with SCC of the tongue were levels Ⅰ-Ⅲ in the ipsilateral neck. Supraomohyoid neck dissection should be the elective treatment to the neck in patients with cN0 SCC of the tongue by consideration of the clinical and pathological factors for the depth of invasion, forms of growth, pathological grade, and degree of differentiation.

关键词： squamous cell carcinoma tongue cancer occult cervical lymph node metastases neck dissection pathology

Unusual locations for differentiated thyroid cancer nodal metastasis

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World Journal of Otorhinolaryngology-Head and neck Surgery 2020年第3期6卷 176-181页

作者： Rohit Ranganath Vaninder K.Dhillon Mohammad Shaear Lisa Rooper Jonathon O.Russell Ralph P.Tufano Department of General Surgery Louisiana State University Health Sciences CenterShreveportLAUSA Division of Head and neck Endocrine Surgery Department of Otolaryngology-Head and Neck SurgerySchool of MedicineThe Johns Hopkins UniversityBaltimoreMDUSA Department of Pathology School of MedicineThe Johns Hopkins UniversityBaltimoreMDUSA

Lymph node metastasis is common in differentiated thyroid cancer especially papillary thyroid *** of lymph node metastasis does not have an impact on survival in younger *** central and lateral neck dissection in the presence of clinically or radiologically evident lymph nodes has resulted in good overall ***,disease persistence in the lymph node/early recurrences may be seen in patients owing to lymph nodes that may be missed during the initial neck *** observed locations are retropharyngeal and parapharyngeal nodal location,retro carotid location,sublingual,axillary,and intraparotid locations,supraclavicular and superficial to the sternothyroid *** aim to highlight these locations with the goal to minimize persistence or early recurrence of disease at these locations.

关键词： Differentiated thyroid cancer Papillary thyroid cancer Nodal metastasis neck dissection Recurrent papillary thyroid cancer

A model to predict nodal metastasis in patients with cN0 T1～T2 tongue squamous cell carcinoma

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A model to predict nodal metastasis in patients with cN0 T1...

2019第一届全国口腔颌面-头颈肿瘤学术大会——聚合引领、协同发展

作者：张成瑶李思毅上海交通大学医学院附属第九人民医院

Purpose/Background:Difficulty in precise decision making on necessity of neck dissection is a controversy when managing T1～T2 tongue squamous cell carcinoma with clinically negative neck. The aim of this study is to develop a model use of clinical and histopathological parameters in combination that predicts the presence of nodal metastasis in patients with cN0 T1～T2 tongue squamous cell carcinoma.

关键词： tongue squamous cell carcinoma nodal metastasis neck dissection nomogram predict model