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“Three birds with one stone”nanoplatform:Efficient near-infrared-triggered type-I AIE photosensitizer for mitochondria-targeted photodynamic therapy against hypoxic tumors

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Aggregate 2024年第4期5卷 279-293页

作者： Shengnan Liu Yu Pei Yan Sun Ziwei Wang Haoran Chen Dongxia Zhu Martin R.Bryce Ben Zhong Tang Yulei Chang Key Laboratory of Nanobiosensing and Nanobioanalysis at Universities of Jilin Province Department of ChemistryNortheast Normal UniversityChangchunJilin ProvincePeople’s Republic of China State Key Laboratory of Luminescence and Applications Changchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of SciencesChangchunJilin ProvincePeople’s Republic of China Department of Chemistry Durham UniversityDurhamUK Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionState Key Laboratory of Molecular NeuroscienceDivision of Life ScienceMing Wai Lau Centre for Reparative MedicineKarolinska Instituteand Guangdong-Hong Kong-Macao Joint Laboratory of Optoelectronic and Magnetic Functional MaterialsThe Hong Kong University of Science and TechnologyKowloonHong KongPeople’s Republic of China School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhenGuangdongPeople’s Republic of China

Currently three major problems seriously limit the practical application of can-cer photodynamic therapy(PDT):(i)the hypoxic tumor microenvironment(TME);(ii)low generation efﬁciency of toxic reactive oxygen species(ROS)in aggre-gates and(iii)shallow tissue penetration depth of excitation *** limited approaches are available for addressing all the above three problems with a single ***,a rational“three birds with one stone”molecular and nanoengi-neering strategy is demonstrated:a photodynamic nanoplatform U-Ir@PAA-ABS based on the covalent combination of lanthanide-doped upconversion nanoparti-cles(UCNPs)and an AIE-active dinuclear Ir(III)complex provides a low oxygen concentration-dependent type-I photochemical process upon 980 nm irradiation by Föster resonance energy transfer(FRET).U-Ir@PAA-ABS targets mitochondria and has excellent phototoxicity even in severe hypoxia environments upon 980 nm irradiation,inducing a dual-mode cell death mechanism by apoptosis and *** together,the in vitro and in vivo results demonstrate a successful strategy for improving the efﬁcacy of PDT against hypoxic tumors.

关键词： hypoxia tumor iridium complex nanoplatform near-infrared photosensitizer photodynamic therapy type-I photosensitizer

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