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Tailoring micro/nano-fibers for biomedical applications

生物活性材料(英文) 2023年第1期19卷 328-347页

作者： Bin Kong Rui Liu Jiahui Guo Ling Lu Qing Zhou Yuanjin Zhao Department of Cardio-Thoracic Surgery Institute of Translational MedicineNanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical School210008NanjingChina Department of Otolaryngology Head and Neck Surgery Jiangsu Provincial Key Medical DisciplineNanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical School210008NanjingChina State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast University210096NanjingChina Institute for Stem Cell and Regeneration Chinese Academy of Science100101BeijingChina

Nano/micro fibers have evoked much attention of scientists and have been researched as cutting edge and hotspot in the area of fiber science in recent years due to the rapid development of various advanced manufacturing technologies,and the appearance of fascinating and special functions and properties,such as the enhanced mechanical strength,high surface area to volume ratio and special functionalities shown in the surface,triggered by the nano or micro-scale dimensions.In addition,these outstanding and special characteristics of the nano/micro fibers impart fiber-based materials with wide applications,such as environmental engineering,electronic and biomedical fields.This review mainly focuses on the recent development in the various nano/micro fibers fabrication strategies and corresponding applications in the biomedical fields,including tissue engineering scaffolds,drug delivery,wound healing,and biosensors.Moreover,the challenges for the fabrications and applications and future perspectives are presented.

关键词： Nano/micro fibers Bioprinting electrospinning Microfluidic spinning near field electrospinning Biomedical field

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near-field electrospun PCL fibers/GelMA hydrogel composite dressing with controlled deferoxamine-release ability and retiform surface for diabetic wound healing

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Nano Research 2023年第1期16卷 599-612页

作者： Huiling Zhong Jun Huang Moucheng Luo Yifei Fang Xinchen Zeng Jun Wu Jianhang Du Medical Research Center The Eighth Affiliated Hospital of Sun Yat-sen UniversityShenzhen 518033China School of Biomedical Engineering Sun Yat-sen UniversityGuangzhou 510006China Institute of Biological and Medical Engineering Guangdong Academy of SciencesGuangzhou 510316China Department of Liver Surgery The Third People’s Hospital of ShenzhenShenzhen 518112China NHC Key Laboratory of Assisted Circulation Sun Yat-sen UniversityGuangzhou 510080China

Wound ulceration caused by diabetes is a typical chronic wound wherein healing the local tissue is difficult due to lack of blood vessels and tissue necrosis caused by the long-term accumulation of free radicals.near-field electrospinning(NFES)is an innovative technology used to produce micro-nano-scaled,controllable sequencing fibers.In this study,we constructed a novel wound dressing based on the NFES polycaprolactone(PCL)fiber network and modified gelatin with methacrylic anhydride(GelMA)hydrogel to promote angiogenesis and the re-epithelialization of diabetic wounds.An angiogenic and antioxidant drug named deferoxamine(DFO)was encapsulated in a GelMA hydrogel to achieve a slow-release effect that is more suitable for chronic wounds.The cell adhesion experiment showed that the cells could attach to the fibers in the dressing group having a network of PCL fibers on the surface and grow along the direction of the fibers,which in turn,effectively regulates cell behavior from the physical structure.Additionally,the large pore size(~500μm)of the network allowed the cells to penetrate the pores and enter the surface of the hydrogel without being blocked out.Besides,the composite dressing had a notable effect on angiogenesis.Furthermore,antioxidation experiments confirmed that the DFO-loaded hydrogel exhibited antioxidant activity.Experimental animal models of diabetes showed that rats treated with the PCL-GelMA-DFO(PGD)hydrogel had faster ability of hemostasis,scab formation,and wound healing.In conclusion,the PGD hydrogel effectively promoted the repair of chronic wounds.

关键词： diabetic wound healing near field electrospinning hydrogel large pore

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