检索结果-南通市图书馆

Outcomes of patients treated with SVILE vs.P-GemOx for extranodal natural killer/T-cell lymphoma,nasal type:a prospective,randomized controlled study

引用

Cancer Biology & Medicine 2020年第3期17卷 795-804页

作者： Liqiang Wei Lei Yang Jin Ye Jia Cong Xin Li Na Yao Jing Yang Xueying Cui Jing Ding Yiping Wu Jingwen Wang Department of Hematology Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China

Objective:To compare the efficacy and safety of the novel SVILE regimen with the P-GemOx regimen in patients with newly diagnosed extranodal natural killer/T-cell lymphoma,nasal type(ND-ENKTL).Methods:From April 2015 to July 2018,103 patients with ND-ENKTL were randomly assigned to SVILE(experimental group)or P-GemOx(control group)chemotherapy followed by radiotherapy and consolidation *** primary endpoint was the overall response rate after 3 cycles of chemotherapy,and secondary study endpoints were complete response(CR),progression-free survival(PFS),and overall survival(OS).Safety was also ***:There were no significant differences in baseline characteristics in the *** *** experimental and control groups,respectively,the overall response rates were 91.7%vs.97.0%for stageI/II and 75.0%vs.72.2%for stage III/*** CR rates were 83.4%vs.97.0%for stage I/II and 68.8%vs.61.1%for stage III/*** of those differences were *** was no significant difference in PFS and OS between groups and between patients in stage I/II and stage III/*** 3-year PFS and OS in stage I/II were 88.3%vs.93.3%and 88.8%vs.97.0%,*** 3-year PFS and OS in stage III/IV were 46.2%vs.65.7%and 68.8%vs.72.2%,*** common adverse events were hematological toxicity,hepatotoxicity,and coagulation abnormalities,which were found to be reversible with supportive ***:The novel SVILE regimen has comparable effects to those of P-GemOx in patients with ND-ENKTL and is well *** is a therapeutic option for ND-ENKTL.

关键词： Extranodal natural killer/T-cell lymphoma nasal type chemotherapy overall response radiotherapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Progress in the treatment of NK-cell lymphoma/leukemia

引用

Journal of Cancer Metastasis and Treatment 2021年第1期7卷 901-914页

作者： Ayumi Fujimoto Ritsuro Suzuki Department of Hematology Shimane University HospitalIzumoShimane 693-8501Japan

Natural killer(NK)/T cell lymphoma includes two major subtypes of disease,specifically extranodal NK/T cell lymphoma,nasal type(ENKL)and aggressive NK cell leukemia(ANKL).Both are strongly associated with Epstein Barr virus and are prevalent in East Asia and Latin *** for that of limited-stage ENKL,the prognosis of both diseases was poor in the previous *** advent of non-anthracycline-based chemoradiotherapy has contributed to an improvement in ENKL prognosis,but there is still room for further treatment ***,the high efficacy of PD-1 antibody was reported in relapsed or refractory ENKL *** was later supported by the finding that PD-L1/PD-L2 genetic alterations are frequently observed in ENKL and ANKL *** to the rarity of the disease,a standard treatment for ANKL remains to be ***,allogeneic stem cell transplantation is the only curative treatment,and this is even applicable to chemo-resistant ANKL *** this review,we focus on recent treatment approaches for NK/T cell lymphomas including novel agents.

关键词： Extranodal NK/T-cell lymphoma nasal type aggressive NK-cell leukemia Epstein-Barr virus hematopoietic stem cell transplantation L-asparaginase

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：