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Hypertriglyceridemia and acute pancreatitis:clinical and basic research—a narrative review

Journal of Pancreatology 2024年第1期7卷 53-60页

作者： Lin Gao Weiqin Li Center of Severe Acute Pancreatitis(CSAP) Department of Critical Care MedicineJinling HospitalMedical School of Nanjing UniversityNanjing 210002JiangsuChina

Hypertriglyceridemia(HTG)is the third most common cause of acute pancreatitis(AP),and the incidence of HTG-induced AP(HTG-AP)is rising worldwide as a result of changes in lifestyle and dietary *** China,HTG accounts for 10%to 20%of the causes of AP,even becoming the second leading cause of *** presentation and diagnosis of HTG-AP is similar to that of AP from other causes,however,the complication rates and severe AP are significantly higher in patients with HTG-AP than in patients with other *** the management of HTG-AP,the initial management is similar to that of AP from other causes and mainly includes fluid resuscitation,pain control,and nutritional *** addition to supportive care,it is necessary to take appropriate measures to decrease serum TG levels,in order to alleviate the progression of AP and prevent *** review aims to summarize existing clinical and basic research evidence of HTG-AP and seeks to highlight the epidemiology,definition,pathogenesis,clinical course,diagnosis,management,prevention of recurrence,and specific clinical scenarios,such as HTG-AP during pregnancy,HTG-AP with diabetic ketoacidosis.

关键词： Acute pancreatitis Basic research Clinical research Hypertriglyceridemia narrative review

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Single nucleotide variations in the development of diabetic foot ulcer: A narrative review

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World Journal of Diabetes 2022年第12期13卷 1140-1153页

作者： Yan-Jun Hu Chen-Sheng Song Nan Jiang Division of Orthopaedics and Traumatology Department of OrthopaedicsSouthern Medical University Nanfang HospitalGuangzhou 510515Guangdong ProvinceChina

Diabetes mellitus has become a global health problem,and the number of patients with diabetic foot ulcers(DFU)is rapidly ***,DFU still poses great challenges to physicians,as the treatment is complex,with high risks of infection,recurrence,limb amputation,and even ***,a comprehensive understanding of DFU pathogenesis is of great *** this review,we summarized recent findings regarding the DFU development from the perspective of single-nucleotide variations(SNVs).Studies have shown that SNVs located in the genes encoding C-reactive protein,interleukin-6,tumor necrosis factor-alpha,stromal cell-derived factor-1,vascular endothelial growth factor,nuclear factor erythroid-2-related factor 2,sirtuin 1,intercellular adhesion molecule 1,monocyte chemoattractant protein-1,endothelial nitric oxide synthase,heat shock protein 70,hypoxia inducible factor 1 alpha,lysyl oxidase,intelectin 1,mitogen-activated protein kinase 14,toll-like receptors,osteoprotegerin,vitamin D receptor,and fibrinogen may be associated with the development of ***,considering the limitations of the present investigations,future multi-center studies with larger sample sizes,as well as in-depth mechanistic research are warranted.

关键词： Diabetic foot Diabetic foot ulcer Diabetic foot osteomyelitis Single nucleotide variations narrative review

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Exosomes:emerging biomarkers unveiling cellular mysteries—a narrative review

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Journal of Bio-X Research 2023年第3期6卷 104-115页

作者： Ijeoma Evangeline Umeche Mathew Folaranmi Olaniyan Department of Medical Laboratory Science Faculty of Applied Health SciencesEdo State University UzairueEdo StateNigeria

Exosomes have gained recognition as potential diagnostic and prognostic markers due to their stability and disease-specific ***,once dismissed as cellular debris,are now acknowledged as crucial mediators of intercellular communications and *** nanosized vesicles transport dynamic cargos consisting of bioactive molecules,including proteins,lipids,and nucleic acids,enabling cells to exchange information and influence each other’s *** review delves into the multifaceted roles of exosomes,particularly their emergence as biomarkers for various *** conduct research for this review,a comprehensive literature search strategy was employed across various databases using keywords related to exosomes,biomarkers,cellular communication,disease diagnosis,and *** articles were evaluated based on their relevance,and data were extracted,synthesized,and categorized according to thematic *** assessment was performed on different types of articles,ensuring robust *** cancer,exosomes act as liquid biopsy samples,revealing genetic mutations,and protein *** misfolded proteins characteristic of neurodegenerative diseases such as Alzheimer disease and Parkinson disease are carried by ***,exosomes have been studied as biomarkers for cardiovascular,infectious,and autoimmune *** addition to their functions as biomarkers,exosomes influence the tumor microenvironment,immune response,synaptic plasticity,and tissue *** remain to fill research gaps and standardize exosome *** are pivotal in intercellular communication and for disease diagnosis,offering insights into cellular processes,immunity,and *** research may reshape our understanding of cellular communication and drive therapeutic *** challenges must be addressed,exosomes hold undeniable potential for use in personalized medicine and biomedical research.

关键词： cellular mysteries emerging biomarkers exosomes narrative review

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Acupuncture as a potential approach to improve the health of women with obesity

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TMR Non-Drug Therapy 2018年第2期1卷 1-13页

作者： Fung-Kei Cheng New Territories Hong Kong

In addition to higher risks of various obstetric and gynaecological illnesses among women with obesity or who are overweight, maternal adiposity threatens the lifetime health of their offspring. Diverse treatments are provided, including complementary and alternative medicine such as Chinese medical practices. Acupuncture, a traditional Chinese medicinal method, is increasingly being applied to this health problem. This literature review analyses 25 clinical studies, involving 2407 participants aged 13-65 in Africa, Asia, the Middle East and North America. This illustrates the use of acupuncture alone or with other approaches to control body weight, obesity-induced diseases, and gynaecological health. Although positive indicators are presented, this study offers recommendations for enhancing reliability and validity in further research. It therefore suggests the use of acupuncture in dealing with obesity due to its efficacy, and economic and safety benefits.

关键词： Acupuncture-complementary and alternative therapy Adiposity Chinese medicine narrative review Obstetrics and gynaecology Weight loss

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Efficacy of acupuncture on treating obesity and adipose-incurred illnesses

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TMR Integrative Medicine 2018年第4期2卷 140-167页

作者： Fung-Kei Cheng Hong Kong

Being overweight and obese impacts health due to adiposity itself and illnesses it incurs,which produces individual and societal financial *** urges effective interventions,including adjunct ***,a traditional Chinese medical practice,indicates positive signs for tackling these *** 101 empirical human-based projects,this narrative review analyses their outcomes and then provides an overview of the effects of acupuncture in body weight reduction and obesity-induced diseases,either performed alone or with other *** involves 15941 participants from 9-80 years old in China's Mainland,Taiwan,Turkey,Brazil,Egypt,Iran,Greece,Korea,Sudan,Thailand,and the *** also reveals practical implications and future research directions,benefiting the development of acupuncture in the modern medical arena for both patients and practitioners.

关键词： Appetite Complementary and alternative therapy narrative review Traditional Chinese medicine Weight reduction

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The current state of knowledge on the clinical and methodological aspects of extracorporeal shock waves therapy in the management of post-stroke spasticity-overview of 20 years of experiences

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中华物理医学与康复杂志 2022年第5期44卷 445-445页

Background and objectives In many patients after stroke, spasticity develops over time, resulting in a decrease in the patient′s independence, pain, worsening mood, and, consequently, lower quality of life. In the last ten years, a rich arsenal of physical agents to reduce muscle tone such as extracorporeal shock therapy (ESWT) wave has come through. The aim of this narrative review article is to present the current state of knowledge on the use of ESWT as a supplement to the comprehensive rehabilitation of people after stroke suffering from *** The PubMed and PEDro databases were searched for papers published in English from January 2000 to December 2020, 22 of which met inclusion criteria for clinical studies related to post-stroke spasticity management with *** A total of 22 studies including 468 post-stroke patients-11 reports with the upper limb (267 patients) and 10 reports within the lower limb (201 patients), as well as one report including both upper and lower limb. We focused our attention on clinical and methodological aspects. Therefore, we performed the assessment of enrolled studies in terms of methodological quality using the PEDro and level of evidence using the National Institute for Health and Clinical Excellence (NICE) guidelines. Furthermore, we indicated implications for clinical practice in using ESWT for post-stroke spasticity management. Moreover, we discussed a suggestion for future research *** In conclusion, an ESWT effectively reduces muscle tone in people with spastic limb after stroke. Further, ESWT is safe and free of undesirable side *** mechanism of action of ESWT on muscles affected by spasticity is still *** date, no standard parameters of ESWT in post-stroke spasticity regarding intensity, frequency, location, and the number of sessions has been established. Further research, meeting the highest standards, is needed to establish uniform muscle stimulation parameters using E

关键词： muscle spasticity narrative review neurorehabilitation physiotherapy shock wave therapy state of art stroke

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