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Aggregate 2024年第1期5卷 244-256页

作者： Xu Chen Meijiao Zhao Qihu Xie Sitong Zhou Xiaoping Zhong Judun Zheng Ronghua Yang Xianjin Du Jinyu Xia Yuhui Liao Department of Infectious Diseases The Fifth Affiliated HospitalSun Yat-sen UniversityZhuhaiChina Molecular Diagnosis and Treatment Center for Infectious Diseases Dermatology HospitalSouthern Medical UniversityGuangzhouChina Department of Burns and Plastic Surgery The Second Affiliated Hospital of Shantou University Medical CollegeShantouChina Department of Dermatology TheFirst People’s Hospital of FoshanFoshanChina Department of Burn and Plastic Surgery Guangzhou First People’s HospitalSouth China University of TechnologyGuangzhouChina Department of Critical Care Medicine Renmin Hospital of Wuhan UniversityWuhanChina

As a high-risk trauma,deep burns are always hindered in their repair process by decreased tissue regeneration capacity and persistent *** this study,we developed a simultaneous strategy for deep burn wounds treatment using functional nanovesicles with antibacterial and tissue remodeling properties,delivered via a click-chemistry *** aggregation-induced emission photosensitizer of 4-(2-(5-(4-(diphenylamino)phenyl)thiophen-2-yl)vinyl)-1-(2-hydroxyethyl)pyridin-1-ium bromide(THB)with excellent photodynamic properties was first prepared,and then combined with readily accessible adipose stem cells-derived nanovesicles to generate the THB functionalized nanovesicles(THB@ANVs).The THB@ANVs showed strong antibacterial activity against Gram-positive bacteria(up to 100%killing rate),and also beneficial effects on tissue remodeling,including promoting cell migration,cell proliferation,and regulating *** addition,we prepared a click-hydrogel of carboxymethyl chitosan for effective delivery of THB@ANVs on *** hydrogel could be injected to conform to the wound morphology while responding to the acidic *** vivo evaluations of wound healing revealed that the THB@ANVs hydrogel dressing efficiently accelerated the healing of second-degree burn wounds by reducing bacterial growth,regulating inflammation,promoting early angiogenesis,and collagen *** study provides a promising candidate of wound dressing with diverse functions for deep burn wound repair.

关键词： aggregation-induced emission burn wounds nanovesicles

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Preparation,physicochemical characterization and cytotoxicity in vitro of gemcitabine-loaded PEG-PDLLA nanovesicles

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World Journal of Gastroenterology 2010年第8期16卷 1008-1013页

作者： Lia, Lin Zheng, Jian-Jun Jiang, Shu-Man Huang, Kai-Hong Guangzhou Med Coll Guangzhou Municipal Peoples Hosp 1 Dept Gastroenterol Guangzhou 510180 Guangdong Peoples R China Zhongshan Univ Dept Gastroenterol Affiliated Hosp 2 Guangzhou 510000 Guangdong Peoples R China

AIM:To investigate the preparation,physicochemical characterization and cytotoxicity in vitro of Gemcitabine-loaded poly(ethylene glycol)-block-poly(D,L-lactide) (PEG-PDLLA) nanovesicles. METHODS:The nanovesicle carriers were prepared from the amphiphilic block copolymer of PEG-PDLLA by a double emulsion technique,and gemcitabine was used as the model drug. The morphology of the nanovesicles was determined by scanning and transmission electron microscopy,and the drug content,drug entrapment and drug-release curve in vitro were detected by UV-Vis-NIR spectrophotometry. Cytotoxicity in the human pancreatic cancer cell line SW1990 was tested by 3-(4,5-dimethyl) ethiazole (MTT) ***:The gemcitabine-loaded nanovesicles were hollow nanospheres with a mean size of 200.6 nm,drugloading of 4.14% and drug embedding ratio of 20.54%. The nanovesicles showed excellent controlled release that was characterized by a fast initial release during the first 72 h,followed by a slower and continuous release. The MTT assay demonstrated that gemcitabine-loaded nanovesicles exhibited dose-dependent and time-delayed cytotoxicity in the human pancreatic cancer cell line ***:Gemcitabine-loaded PEG-PDLLA nanovesicles prepared by a double emulsion technique exhibited good performance for controlled drug release,and had similar cytotoxic activity to free gem-citabine.

关键词： Copolymer Cytotoxicity Gemcitabine nanovesicles

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Cytotoxicity and Selectivity in Skin Cancer by SapC-DOPS nanovesicles

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Journal of Cancer Therapy 2012年第4期3卷 321-326页

作者： Shadi Abu-Baker Zhengtao Chu Ashley M. Stevens Jie Li Xiaoyang Qi Department of Dermatology University of Miami Miami FL Division of Hematology/Oncology Department of Internal Medicine University of Cincinnati College of Medicine Division of Human Genetics Department of Pediatrics Cincinnati Children’s Hospital Medical Center Cincinnati OH

Squamous cell carcinoma (SCC) and melanoma are malignant human cancers of the skin with an annual mortality that exceeds 10,000 cases every year in the USA alone. In this study, the lysosomal protein saposin C (SapC) and the phospholipid dioloylphosphatidylserine (DOPS) were assembled into cancer-selective nanovesicles (SapC-DOPS) and successfully tested using several in vitro and in vivo skin cancer models. Using MTT assay that measures the percentage of cell death, SapC-DOPS cytotoxic effect on three skin tumor cell lines (squamous cell carcinoma, SK-MEL-28, and MeWo) was compared to two normal nontumorigenic skin cells lines, normal immortalized keratinocyte (NIK) and human fibroblast cell (HFC). We observed that the nanovesicles selectively killed the skin cancer cells by inducing apoptotic cell death whereas untransformed skin cancer cells remained unaffected. Using subcutaneous skin tumor xenografts, animals treated with SapC-DOPS by subcutaneous injection showed a 79.4% by volume tumor reduced compared to the control after 4 days of treatment. We observed that the nanovesicles killed skin cancer cells by inducing apoptotic cell death compared to the control as revealed by TUNEL staining of xenograft tumor sections.

关键词： Squamous Cell Carcinoma Melanoma SapC-DOPS nanovesicles Cytotoxic Effect Cancer Selectivity

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Targeted Macromolecules Delivery by Large Lipidic nanovesicles Electrofusion with Mammalian Cells

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Journal of Biomaterials and Nanobiotechnology 2011年第5期2卷 527-532页

作者： Demange Pascal Réat Valérie Weinandy Stefan Ospital Remy Chopinet-Mayeux Louise Henri Pauline Milon Alain Teissié Justin 不详

Lipidic nanovesicles (so called liposomes) were one the earliest forms of nanovectors. One of their limits was our lack of knowledge on the delivery pathway of their content to the target cell cytoplasm. The present communication describes an efficient way to enhance the delivery. Pulsed electric fields (PEF) are known since the early 80’s to mediate a fusogenic state of plasma membranes when applied to a cell suspension or a tissue. Polykaryons are detected when PEF are applied on cells in contact during or after the pulses. Heterofusion can be obtained when a cell mixture is pulsed. When lipidic nanovesicles, either small unilamellar vesicles (SUVs) or large unilamellar vesicles (LUVs), are electrostatically brought in contact with electropermeabilized cells by a salt bridge, their content is delivered into the cytoplasm in electropermeabilized cells. The PEF parameters are selected to affect specifically the cells leaving the vesicles unaffected. It is the electropermeabilized state of the cell membrane that is the trigger of the merging between the plasma membrane and the lipid bilayer. The present investigation shows that the transfer of macromolecules can be obtained;i.e. 20 kD dextrans can be easily transferred while a direct transfer does not take place under the same electrical parameters. Cell viability was not affected by the treatment. As delivery is present only on electropermeabilized cells, a targeting of the effect is obtained in the volume where the PEF parameters are over the critical value for electropermeabilization. A homogeneous cytoplasm labeling is observed under digitised videomicroscopy. The process is a content and “membrane” mixing, following neither a kiss and run or an endocytotic pathway.

关键词： Electrofusion Delivery Systems in Cancer Liposomes Lipidic nanovesicles

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Herbal medicine-derived nanovesicles: basic characteristics and biological activities

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TMR Modern Herbal Medicine 2023年第1期6卷 14-23页

作者： Sheng-Jie Huang Cheng-Juan Liu Rui-Jiao Du Jie-Rong Pei Miao-Miao Jiang State Key Laboratory of Component-based Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Haihe Laboratory of Modern Chinese Medicine Tianjin 301617China

Herbal medicine(HM)has been extensively researched and widely used since ancient ***,as one of the emerging directions in HM modernization research,herbal medicine-derived nanovesicles(HMDNV),a type of nanoparticle obtained from destructed plant tissues,hold considerable promise for disease treatment and drug *** recent studies related to HMDNV and miRNAs are summarized in this review,with a special emphasis on their basic characteristics and biological activities,to provide ideas for future scientific research on HMDNV and enrich the content of active components of Traditional Chinese Medicine(TCM).

关键词： Herbal medicine nanovesicles miRNA Components Traditional Chinese medicine

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Finite Indentation of Pressurized Elastic Fluid Nano vesicles by a Rigid Cylindrical Indenter

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Acta Mechanica Solida Sinica 2019年第5期32卷 633-642页

作者： Xingyi Tang Jianxiang Wang Xin Yi Department of Mechanics and Engineering Science College of EngineeringPeking UniversityBeijing 100871China CAPT HEDPS and IFSA Collaborative Innovation Center of MoEPeking UniversityBeijing 100871China Beijing Innovation Center for Engineering Science and Advanced Technology Peking UniversityBeijing 100871China

nanovesicles have been demonstrated to be the key agents in therapeutic encapsulations for drug delivery and diagnostic area,and the effectiveness and efficiency of these applications strongly depend on the mechanical properties of *** on the Helfrich membrane theory,a theoretical investigation is conducted to explore the mechanical behaviors of pressurized elastic fluid nanovesicles during the indentation by a rigid cylindrical *** effects of osmotic pressure,membrane bending rigidity,energy of adhesion bet ween the vesicle and substrate on the mechanical responses of the vesicle to the indentation are *** is found that the osmotic pressure dominates the mechanical behaviors of strongly pressurized nanovesicles as well as the effective vesicle stiffness and Young's *** results may have important implications on regulating the mechanical behaviors of inter-and intracellular nanovesicles which are crucial for particle-based drug delivery systems.

关键词： nanovesicles Indentation Osmotic pressure Young's modulus Stiffness Forcedepth curves

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Endogenous nucleotide as drug carrier:base-paired guanosine-5’-monophosphate:pemetrexed vesicles with enhanced anticancer capability

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Science China Chemistry 2020年第2期63卷 244-253页

作者： Lei Xu Chunyang Yu Dali Wang Ji Pang Leilei Shi Yue Su Lidong Gong Deyue Yan Xinyuan Zhu School of Chemistry and Chemical Engineering State Key Laboratory of Metal Matrix CompositesShanghai Jiao Tong UniversityShanghai 200240China School of Chemistry and Chemical Engineering Liaoning Normal UniversityDalian 116029China

Endogenous substance such as nucleotide as a drug carrier has been proposed as a novel drug delivery *** nucleotide guanosine-5’-monophosphate(GMP) is used to transport an anticancer drug pemetrexed disodium heptahydrate(PMX) via specific base *** endogenous nature of GMP helps to avoid biocompatibility issues that are generally accompanied with nanocarriers including cytotoxicity,immunogenicity and blood ***,the low-molecular weight of the GMP nucleotide carrier significantly boosts the drug loading capacity compared to traditional liposomes and high-molecular weight ***-bonding interaction between the carrier and drug realizes the controlled release of loaded drug,and also facilitates large scale manufacture since no additional chemical synthesis is *** importantly,in vivo experiments reveal that the base-paired GMP:PMX nanovesicles improve the target specificity and pharmacokinetic properties of PMX,and exhibit remarkably enhanced anticancer abilities compared to standalone PMX without any *** envision that this strategy could be extended to other endogenous substances and drugs bearing functional groups capable of specific interaction,and promote the construction of drug delivery systems with inherent biocompatibility,enhanced drug delivery efficacy,and a simplified preparation method.

关键词： endogenous carrier hydrogen bonding nanovesicles drug delivery cancer therapy

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