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Fabrication of Novel Scaffolds Containing Collagen-I/Polylactic Acid/nanohydroxyapatite via Co-electrospinning Methods

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Chemical Research in Chinese Universities 2010年第4期26卷 662-666页

作者： ZANG Jun-ting QI Xin LI Shu-qiang LI Dong-song GONG Yu-bao YANG Chen XU Feng LIU Jian-guo Department of Bone and Joint Surgery First Hospital of Jilin University Changchun 130021 P R. China

A novel scaffold containing collagen-I/polylactic acid（PLA）/nanohydroxyapatite（nHA） was prepared via co-electrospinning method. Different target substrates were used to improve the collection efficiency of this scaffold. The properties of the novel scaffold were compared with those of conventionally prepared ones. Compared to con- ventional method, the modified method was more efficient in producing the scaffold. Moreover, the porosity, thickness, and morphology of the novel scaffold were better than those of scaffolds prepared by conventional methods. The properties of collagen-I, collagen-I/PLA and collagen-I/PLA/nHA scaffolds were also compared. Diameters of the electrospun fibers ranged from 180 to 405 nm, and roughness was present on the surface of the fibers due to the deposition of crystals of nHA along the long axis of the fibers. The fibers of the collagen-I/PLA/nHA scaffold and the fibers of natural bone tissue had similar structure.

关键词： Electrospinning Collagen-I PLA nanohydroxyapatite

The Properties of nanohydroxyapatite Materials and its Biological Effects

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Materials Sciences and Applications 2010年第2期1卷 81-90页

作者： Xiaofeng Pang Hongjuan Zeng Jialie Liu Shicheng Wei Yufeng Zheng 不详

The nanohydroxyapatites (HAP) and its biological effects have been studied using ultraviolet absorption spectrum, X-ray diffraction (XRD) structure analysis, fluorescent and infrared spectrum of absorption and MTT method. The nanohyd- roxyapatites are prepared and made by using Sol-gel method, in which the parameters of process and reaction are controlled as: PH >9, Ca/P = 1.67, sintering temperature of 1100?C and sintering time 2 hours. The results of the study show that nanohydroxyapatites can absorb the amino acid molecules, the absorption is better for stronger acidity of amino acids. We also find that the nanohydroxyapatites and complex of nanoHAP+ nanoCrO2 can all restrain the proliferation of cells, but their toxiciteis are all first degree or minor, but the restrained effect of the latter is smaller than that of the former, although they can decrease the relative proliferation rate of cells. The nanohydroxyapatites can also change the molecular structure of human serum albumin.

关键词： nanohydroxyapatite Cell Biological Effect Toxicity Amino Acids Sol-Gel

Osteogenic composite nanocoating based on nanohydroxyapatite, strontium ranelate and polycaprolactone for titanium implants

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Transactions of Nonferrous Metals Society of China 2018年第9期28卷 1763-1773页

作者： Murat Taner VURAT Ayse Eser ELCIN Yasar Murat ELCIN Tissue Engineering Biomaterials and Nanobiotechnology LaboratoryFaculty of Science and Stem Cell InstituteAnkara UniversityAnkara 06100Turkey Biovalda Health Technologies Inc.Ankara 06830Turkey

Titanium and its alloys are commonly used as dental and bone implant *** coating of titanium surfaces could improve their osteoinductive *** this work,we have developed a novel osteogenic composite nanocoating for titanium surfaces,which provides a natural environment for facilitating adhesion,proliferation,and osteogenic differentiation of bone marrow mesenchymal stem cells(MSCs).Electrospinning was used to produce composite nanofiber coatings based on polycaprolactone(PCL),nano-hydroxyapatite(nHAp)and strontium ranelate(SrRan).Thus,four types of coatings,i.e.,PCL,PCL/nHAp,PCL/SrRan,and PCL/nHAp/SrRan,were applied on titanium *** assess chemical,morphological and biological properties of the developed coatings,EDS,FTIR,XRD,XRF,SEM,AFM,in-vitro cytotoxicity and in-vitro hemocompatibility analyses were *** findings have revealed that the composite nanocoatings were both cytocompatible and hemocompatible;thus PCL/HAp/SrRan composite nanofiber coating led to the highest cell *** culture of MSCs on the nanocoatings led to the osteogenic differentiation of stem cells,confirmed by alkaline phosphatase activity and mineralization *** findings support the notion that the proposed composite nanocoatings have the potential to promote new bone formation and enhance bone-implant integration.

关键词： osteogenic nanocoating composite nanofiber titanium implant nanohydroxyapatite strontium ranelate polycaprolactone electrospinning mesenchymal stem cells

Preparation and Physicochemical Properties of Hydroxyapatite/Polyurethane Nanocomposites

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Chinese Journal of Polymer Science 2014年第4期32卷 467-475页

作者：罗建斌 Shu-xuan Qiu Yong-li Wang Rong-hui Lai 谢兴益 College of Chemical Engineering and Environmental Protection Southwest University for Nationalities Department of Polymeric Biomaterials and Artificial Organs College of Polymer Science and EngineeringSichuan University

In this study, nanohydroxyapatite/polyurethane （nHA/PU） composites with various contents of methoxy- poly（ethylene glycol） modified nHA （0 wt%, 10 wt%, 20 wt% and 30 wt%） were prepared by solution blending process. The physicochemical properties of the composite membranes were investigated by Fourier transform infrared spectroscopy （FTIR）, X-ray diffraction （XRD）, Transmission electronic microscopy （TEM）, Differential scanning calorimetry （DSC）, Thermo gravimetric analysis （TGA） and tensile tests. TEM photos of the nanocomposites showed that the nHA was uniformly dispersed in the polymer matrix. The membrane with 10 wt% nHA showed the highest tensile strength which was about 75% higher than that of the pure PU membrane. However, the tensile strength decreased when high content （above 20 wt%） fillers were added, which was still higher than that of pure PU. TGA measurements suggested that the thermal stability of the membranes was improved owing to nHA fillers. XRD and DSC results illustrated that the crystallinity of PU soft segments decreased with the increasing content of nanoparticles in the composites.

关键词： Biodegradable polyurethane nanohydroxyapatite Composites Physicochemical properties.LICTION

Novel synthesis method combining a foaming agent with freeze-drying to obtain hybrid highly macroporous bone scaffolds

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Journal of Materials Science & Technology 2020年第8期36卷 52-63页

作者： Paulina Kazimierczak Aleksandra Benko Krzysztof Palka Cristina Canal Dorota Kolodynska Agata Przekora Department of Biochemistry and Biotechnology Medical University of LublinChodzki 120-093LublinPoland AGH University of Science and Technology Faculty of Materials Science and CeramicsA.Mickiewicza 30 Ave.30-059KrakowPoland Department of Materials Engineering Lublin University of TechnologyNadbystrzycka 3620-618LublinPoland Biomaterials Biomechanics and Tissue Engineering GroupDepartment of Materials Science and MetallurgyUniversitat Politècnica de CatalunyaBarcelona08019Spain Research Centre in Multiscale Science and Engineering Universitat Politècnica de CatalunyaBarcelona08019Spain Department of Inorganic Chemistry Maria Curie-Sklodowska UniversityMaria Curie Sklodowska Sq.220-031LublinPoland

Three-dimensional macroporous scaffolds are commonly used in bone tissue engineering applications since they provide sufficient space for cell migration and proliferation, facilitating bone ingrowth and implant vascularisation. The aim of this work was to combine two simple methods, freeze-drying and gas-foaming, in order to fabricate highly macroporous bone scaffolds made of chitosan/agarose matrix reinforced with nanohydroxyapatite. The secondary goal of this research was to comprehensively assess biomedical potential of developed biomaterials. In this work, it was demonstrated that simultaneous application of freeze-drying and gas-foaming technique allows to obtain hybrid(as proven by ATR-FTIR)macroporous bone scaffolds(pore diameter > 50 um) characterized by high open(70%) and interconnected porosity. Novel scaffolds were non-toxic, favoured osteoblasts adhesion and growth and induced apatite formation on their surfaces, indicating their high bioactivity that is essential for good implant osseointegration. Biomaterials were also prone to enzymatic degradation, degradation in acidified microenvironment(e.g. osteoclast-mediated), and slow degradation under physiological p H of ***, the scaffolds revealed microstructure(70% open porosity, SSA approx. 30 m2/g, high share of macropores with diameter in the range 100-410 um) and compressive strength(1–1.4 MPa) comparable to cancellous bone, indicating that they are promising implants for cancellous bone regeneration.

关键词： Agarose Chitosan nanohydroxyapatite Biomaterial porosity Biodegradation Cryogel

3D PLLA/Nano-hydroxyapatite Scaffolds with Hierarchical Porous Structure Fabricated by Low-temperature Deposition Manufacturing

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Journal of Wuhan University of Technology(Materials Science) 2012年第2期27卷 265-269页

作者：梁迎春郑雄飞 Precision Engineering Research Institute Harbin Institute of Technology

A new Precision Extrusion nozzle based ball screw transmission was developed. 3D hierarchical porous PLLA/nano-Hydroxyapatite（PLLA/nHA） scaffolds were fabricated by low-temperature deposition manufacturing. Scaffolds with macropores of 200-500 rtm and micropores about 10 pm were fabricated through a thorough study and control of the processing parameters, in which the processing path and speed of material extrusion determine the macropores and there is a suitable temperature zone for fabricating qualified macropores. Micropore morphology can be controlled by adjusting supercooling of solvent crystallization or adding water into the solvent system. The compressive modulus of the scaffolds in air and phosphate buffer solution was measured, which increased with HA addition. In-vitro cell culture results showed a ~ood biocomoatibilitv of PLLA/HA scaffolds with the ore-osteoblastic MC3T3-E1 cells.

关键词： tissue engineering rapid prototyping low-temperature deposition scaffold PLLA nanohydroxyapatite

Interface and Surface Properties of Nano-hydroxyapatite /Poly (1,4-PhenyleneSulfide)-Poly(2,4-Phenylene Sulfide Acid) Copolymer Composite

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High Technology Letters 2003年第1期9卷 26-30页

作者：严永刚 LI Yubao Wei Jie Zuo Yi J.G.C.Wolke J.A.Jansen Institute of Materials Science & Technology Sichuan University Sichuan 610064 P.R China Dept. of Biomaterials University Medical Center 6500 HB Nijmegen The Netherlands

The interface and surface properties of nano-hydroxyapatite(n-HA) and poly( 1, 4-phenylene sulfide)-poly (2,4-phenylene sulfide acid)(PPS-PPSA) copolymer composite were investigated. The results show that there are some strong interface combinations of calcium ion (Ca2+ ), car-boxyl (-COO- ) and phosphate radicle ion (PO_4~3- ) between copolymer and n-HA in the composite. The presence of the 2,4-phenylene sulfide acid in copolymer can increase the affinity to n-HA, which causes the formation of chemical bindings between the PPS-PPSA copolymer and n-HA. XRD analysis and IR surface analysis indicate that n-HA is not encapsulated by copolymer but exposed on the surface of the composite, and has same structure and properties with the origi-nal n-HA. The presence of the interface chemical bindings between the PPS-PPSA copolymer and n-HA can increase the content of n-HA in composite but does not cause the decrease of the composite mechanical strength.

关键词： PPS-PPSA copolymer nanohydroxyapatite composite interface and surface biomaterials