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A scaffold with zinc-whitlockite nanoparticles accelerates bone reconstruction by promoting bone differentiation and angiogenesis

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Nano Research 2023年第1期16卷 757-770页

作者： Mingming Wang Jiaxin Yao Shihong Shen Chunning Heng Yanyi Zhang Tao Yang Xiaoyan Zheng Shaanxi Key Laboratory of Degradable Biomedical Materials Shaanxi R&D Center of Biomaterials and Fermentation EngineeringSchool of Chemical EngineeringNorthwest UniversityXi’an 710069China Biotech.&Biomed.Research Institute Northwest UniversityXi’an 710069China Xi’an Giant Biogene Technology Co. Ltd.Xi’an 710069China Shaanxi Key Laboratory for Theoretical Physics Frontiers Institute of Modern PhysicsNorthwest UniversityXi’an 710127China

The therapy of bone defects based on advanced biological scaffolds offers the most promising therapeutic strategy for bone reconstruction.It is still challenging to develop scaffolds with the mechanical,osteogenic,angiogenic,and antibacterial properties required for bone defect reconstruction.Here,a novel organic/inorganic composite scaffold(zinc-whitlockite(ZnWH)/G/H)was synthesized using gellan gum(GG),human-like collagen(HLC),and ZnWH nanoparticles.The scaffold had excellent mechanical properties,adjustable swelling ratio,and interconnected pore structure.In addition to its excellent biocompatibility,it could promote osteogenic differentiation by releasing ZnWH nanoparticles to stimulate human bone marrow mesenchymal stem cells(hBMSCs)to upregulate the levels of alkaline phosphatase(ALP),osteocalcin(OCN),and osteopontin(OPN).In addition,this study showed that ZnWH nanoparticles could also promote angiogenesis by upregulating the paracrine secretion of vascular endothelial growth factor(VEGF)in hBMSCs.At the same time,the scaffold could inhibit the proliferation of bacteria.After 12 weeks of treatment in the rabbit femoral defect model,the ZnWH/G/H scaffold significantly accelerated the process of bone reconstruction.Therefore,these results demonstrate that the prepared novel nanocomposite scaffold,ZnWH/G/H,offers a promising candidate for bone regeneration.

关键词： bone repair nanocomposite scaffold zinc-whitlockite osteogenesis angiogenesis

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Surface modification of three-dimensional Ca-P/PHBV nanocomposite scaffolds by physical entrapment of gelatin and its in vitro biological evaluation

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Frontiers of Materials Science 2011年第1期5卷 57-68页

作者： Bin DUAN Min WANG Zhao Yang LI Wai Chun CHAN William W. LU Department of Mechanical Engineering Faculty of Engineering The University of Hong Kong Pokfulam Road Hong Kong China Department of Orthopaedics and Traumatology Faculty of Medicine The University of Hong Kong Sassoon Road Hong Kong China

The properties of bone tissue engineering scaffolds such as architecture, porosity, mechanical properties and surface properties have significant effects on cellular response and play an important role in bone regeneration. In this study, threedimensional nanocomposite scaffolds consisting of calcium phosphate （Ca-P） nanoparticles and poly（hydroxybutyrate-co-hydroxyvalerate）（PHBV） copolymer with controlled external and internal architectures were successfully produced via selective laser sintering （SLS）, one of the versatile rapid prototyping techniques. The Ca-PIPHBV nanocomposite scaffolds had a porosity of （61.75±1.24）%, compressive strength of （2.16±0.21） MPa and Young＇s modulus of （26.98±2.29） MPa. The surface modification of scaffolds by gelatin was achieved through physical entrapment. The amount of entrapped gelatin could be controlled by varying the solvent composition and reaction time. The surface modification improved the hydrophilicity of scaffolds but did not significantly affect the surface morphology and mechanical properties. Osteoblast-like cells （SaOS-2） were cultured on scaffolds with and without gelatin surface modification. The majority of SaOS-2 cells were viable and proliferated in both types of scaffolds for up to 14 d in culture, as indicated by MTT assay and live and dead assay. Surface modification significantly increased cell proliferation for surface modified scaffolds, which could be due to the improvement in hydrophilicity of the scaffolds.

关键词： nanocomposite scaffold selective laser sintering surface modification physical entrapment cell behaviour

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