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Dendritic platinum-copper bimetallic nanoassemblies with tunable composition and structure： Arginine-driven self-assembly and enhanced electrocatalytic activity

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Nano Research 2016年第3期9卷 755-765页

作者： Gengtao Fu Huimin Liu Nika You Jiayan Wu Dongmei Sun Lin Xu Yawen Tang Yu Chen Key Laboratory of Macromolecular Science of Shaanxi Province School of Materials Science and Engineering Shaanxi Normal University Xi'an 710062 China Jiangsu Key Laboratory of New Power Batteries Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials School ot Chemistry and Materials Science Nanjing Normal University Nanjing 210023 China Materials Science and Engineering Program & Texas Materials Institute The University of Texas atAustin Austin Texas 78712 USA

Novel self-assembled architectures have received a growing amount of attention and have significant potential for application in catalysis/electrocatalysis. Herein, we take advantage of the unique coordination and self-assembly properties of arginine for the preparation of dendritic PtCu bimetallic nanoassemblies with tunable chemical composition and structure. Strong interactions between the arginine molecules are key in driving the self-assembly of primary nanocrystals. In addition, the strong coordination interactions between arginine and metal ions is responsible for the formation of Pt-Cu alloys. We also investigated the electrocatalytic activity of various dendritic PtCu bimetallic nanoassemblies towards the methanol oxidation reaction. PtBCUl nanoassemblies exhibited excellent electrocatalytic activity and stability in comparison with other PtCu bimetallic nanoassemblies （PtlCu3, PtlCu~） and commercial Pt black, due to their unique dendritic structures and the synergistic effect between the Pt and Cu atoms.

关键词： platinum-copper nanoassemblies arginine molecules electrocatalysis methanol oxidation

Amorphous 3D pomegranate-like NiCoFe nanoassemblies derived by bi-component cyanogel reduction for outstanding oxygen evolution reaction

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Journal of Energy Chemistry 2021年第2期30卷 260-267,I0009页

作者： Zi-Juan Wang Mi-Xue Jin Lu Zhang Ai-Jun Wang Jiu-Ju Feng Key Laboratory of the Ministry of Education for Advanced Catalysis Materials College of Chemistry and Life SciencesCollege of Geography and Environmental SciencesZhejiang Normal UniversityJinhua 321004ZhejiangChina

As a representative type of self-supported templates, cyano-bridged cyanogels provide ideal plateaus for synthesis of three-dimensional(3 D) nanostructures. Herein, 3 D pomegranate-like Fe-doped NiCo nanoassemblies(3 D PG-NiCoFe NAs) were synthesized via facile one-step bi-component cyanogel reduction with NaBH_4 as the reducing agent. Specifically, the influence of the incorporated Fe amount was carefully investigated by finely adjusting the feeding molar ratios of the Ni/Co/Fe atoms in the *** virtue of the unique structure and enriched oxygen vacancies originated from well-modulated electronic structures, the 3 D PG-NiCoFe-211 NAs exhibited outstanding electrocatalytic performances for oxygen evolution reaction(OER) in alkaline solution, outperforming commercial RuO_2 catalyst. The current incorporation of foreign metal atom into host material provides some valuable insights into design and synthesis of metal-based nanocatalysts for constructing practical water splitting devices.

关键词： Transition-metal-based nanocatalysts Cyanogel Three-dimensional pomegranate-like nanoassemblies Oxygen vacancy Oxygen evolution reaction

M13 Bacteriophage-Polymer nanoassemblies as Drug Delivery Vehicles

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Nano Research 2011年第5期4卷 483-493页

作者： Nisaraporn Suthiwangcharoen Tao Li Kai Li Preston Thompson Shaojin You Qian Wang Department of Chemistry and Biochemistry and Nanocenter University of South Carolina Columbia SC 29208 USA Histo-Pathology Core Atlanta VA Medical Center 1670 Clairmont Road Decatur GA 30033 USA

Poly（caprolactone-b-2-vinylpyridine）（PCL-P2VP） coated with folate-conjugated M13 （FA-M13） provides a nanosized delivery system which is capable of encapsulating hydrophobic antitumor drugs such as doxorubicin （DOX）. The DOXqoaded FA-M13-PCL-P2VP assemblies had an average diameter of approximately 200 nm and their structure was characterized using transmission electron microscopy, scanning electron microscopy, and dynamic light scattering. The particles were stable at physiological pH but could be degraded at a lower pH. The release of DOX from the nanoassemblies under acidic conditions was shown to be significantly faster than that observed at physiological pH. In addition, the DOX-loaded FA-M13-PCL-P2VP particles showed a distinctly greater cellular uptake and cytotoxicity against folate-receptor-positive cancer cells than folate-receptor-negative cells, indicating that the receptor facilitates folate uptake via receptor-mediated endocytosis. Furthermore, the DOX-loaded particles also had a significantly higher tumor uptake and selectivity compared to free DOX. This study therefore offers a new way to fabricate nanosized drug delivery vehicles.

关键词： Bacteriophage M13 nanoassemblies doxorubicin drug delivery polymer

The effect of lengths of branched-chain fatty alcohols on the efficacy and safety of docetaxel-prodrug nanoassemblies

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1400-1411页

作者： Shuo Wang Tian Liu Yuetong Huang Chaoying Du Danping Wang Xiyan Wang Qingzhi Lv Zhonggui He Yinglei Zhai Bingjun Sun Jin Sun Wuya College of Innovation Shenyang Pharmaceutical UniversityShenyang 110016China School of Pharmacy Shenyang Pharmaceutical UniversityShenyang 110016China School of Medical Devices Shenyang Pharmaceutical UniversityShenyang 110016China School of Pharmacy Binzhou Medical UniversityBinzhou 256600China

The self-assembly prodrugs are usually consisted of drug modules,activation modules,and assembly *** the balance between efficacy and safety by selecting suitable modules remains a challenge for developing prodrug *** study designed four docetaxel(DTX)prodrugs using disulfide bonds as activation modules and different lengths of branched-chain fatty alcohols as assembly modules(C_(16),C_(18),C_(20),and C_(24)).The lengths of the assembly modules determined the self-assembly ability of prodrugs and affected the activation modules’*** extension of the carbon chains improved the prodrugs’self-assembly ability and pharmacokinetic behavior while reducing the cytotoxicity and increased cumulative *** use of C_(20) can balance efficacy and *** results provide a great reference for the rational design of prodrug nanoassemblies.

关键词： Prodrugs nanoassemblies Self-assembly Branched-chain fatty alcohols Disulfide bond Docetaxel Efficacy Safety

Redox-sensitive prodrug nanoassemblies based on linoleic acid-modified docetaxel to resist breast cancers

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Acta Pharmaceutica Sinica B 2019年第2期9卷 421-432页

作者： Meng Li Liwen Zhao Tao Zhang Yue Shu Zhonggui He Yan Ma Dan Liu Yongjun Wang Wuya College of Innovation Shenyang Pharmaceutical University School of Chinese Materia Medica Guangzhou University of Chinese Medicine Key Laboratory of Structure-Based Drug Design and Discovery Ministry of Education Shenyang Pharmaceutical University

Prodrug nanoassemblies, which can refrain from large excipients, achieve higher drug loading and control drug release, have been placed as the priority in drug delivery system. Reasoning that glutathione(GSH) and reactive oxygen species(ROS) are highly upgraded in tumor tissues which makes them attractive targets for drug delivery system, we designed and synthetized a novel prodrug which utilized mono thioether bond as a linker to bridge linoleic acid(LA) and docetaxel(DTX). This mono thioether-linked conjugates(DTX-S-LA) could self-assemble into nanoparticles without the aid of much excipients. The mono thioether endowed the nanoparticles redox sensitivity resulting in specific release at the tumor tissue. Our studies demonstrated that the nanoassemblies had uniform particle size, high stability and fast release behavior. DTX-S-LA nanoassemblies outperformed DTX solution in pharmacokinetic profiles for it had longer circulation time and higher area under curve(AUC). Compared with DTX solution, the redox dual-responsive nanoassemblies had comparable cytotoxic activity. Besides, the antitumor efficacy was evaluated in mice bearing 4 T1 xenograft. It turned out this nanoassemblies couldenhance anticancer efficacy by increasing the dose because of higher tolerance. Overall, these results indicated that the redox sensitivity nanoassemblies may have a great potential to cancer therapy.

关键词： Docetaxel nanoassemblies Mono thioether bond Linoleic acid Pharmacokinetics Antitumor efficacy

Amphiphilic small molecular mates match hydrophobic drugs to form nanoassemblies based on drug-mate strategy

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Asian Journal of Pharmaceutical Sciences 2022年第1期17卷 129-138页

作者： Leiqiang Han Shuang Liang Weiwei Mu Zipeng Zhang Limin Wang Shumin Ouyang Bufan Yao Yongjun Liu Na Zhang Department of Pharmaceutics Key Laboratory of Chemical Biology(Ministry of Education)School of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China

Nanomedicine has made great progress in the targeted therapy of cancer. Here, we established a novel drug-mate strategy by studying the formulation of nanodrugs at the molecular level. In the drug-mate combination, the drug is a hydrophobic drug that is poorly soluble in water, and the mate is an amphiphilic small molecule (SMA) that has both hydrophilic and lipophilic properties. We proposed that the hydrophobic drug could co-assemble with a suitable SMA on a nanoscale without additive agents. The proof-ofconcept methodology and results were presented to support our hypothesis. We selected five hydrophobic drugs and more than ten amphiphilic small molecules to construct a library. Through molecular dynamic simulation and quantum chemistry computation,we speculated that the formation of nanoassemblies was related to the binding energy of the drug-mate, and the drug-mate interaction must overcome drug-drug ***, the obtained SF/VECOONa nanoassemblieswas selected as a model, which had an ultra-high drug loading content (46%), improved pharmacokinetics, increased bioavailability, and enhanced therapeutic efficacy. In summary, the drug-mate strategy is an essential resource to design exact SMA for many hydrophobic drugs and provides a reference for the design of a carrier-free drug delivery system.

关键词： Drug-mate strategy Molecular level Hydrophobic drug Small molecular mate nanoassemblies

Charge-Transfer Supra-amphiphiles Built by Water-Soluble Tetrathiafulvalenes and Viologen-Containing Amphiphiles

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Charge-Transfer Supra-amphiphiles Built by Water-Soluble Tet...