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nanocarrier of Pin1 inhibitor based on supercritical fluid technology inhibits cancer metastasis by blocking multiple signaling pathways

引用

Regenerative Biomaterials 2023年第1期10卷 574-589页

作者： Fengzhu Zhang Aiwen Zhang Youning Xie Haiying Wen Ranjith Kumar Kankala Jing Huang Anjun Zhang Qi Wang Biaoqi Chen Haiyan Dong Zhao Guo Aizheng Chen Dayun Yang Fujian Key Laboratory of Translational Research in Cancer and Neurodegenerative Diseases School of Basic Medical SciencesFujian Medical UniversityFuzhou350108PR China Institute of Biomaterials and Tissue Engineering Huaqiao UniversityXiamen361021PR China Fujian Provincial Key Laboratory of Biochemical Technology(Huaqiao University) Xiamen361021PR China

Cancer metastasis is the primary cause of all cancer-related deaths due to the lack of effective targeted drugs that simultaneously block multiple signaling pathways that drive the dissemination and growth of cancer *** unique proline isomerase Pin1 activates numerous cancer pathways,but its role in cancer metastasis and the inhibitory efficacy of Pin1 inhibitors on cancer metastasis are ***,the applicability of Pin1 inhibitor-all-trans retinoic acid(ATRA)is limited due to its several ***,uniform ATRA-loaded polylactic acid-polyethylene glycol block copolymer nanoparticles(ATRA-NPs)with high encapsulation efficiency,good cellular uptake,excellent controlled release performance and pharmacokinetics are developed using supercritical carbon dioxide processing combined with an optimized ***-NPs exhibited excellent biosafety and significant inhibition on the growth and metastasis of hepatocellular ***1 played a key role in cancer metastasis and was the main target of ***-NPs exerted their potent anti-metastatic effect by inhibiting Pin1 and then simultaneously blocking multiple signaling pathways and cancer epithelial-mesenchymal *** ATRA-NPs could effectively couple the inhibition of cancer cell dissemination with cancer growth,it provided a novel therapeutic strategy for efficiently inhibiting cancer metastasis.

关键词： cancer metastasis targeted therapy Pin1 inhibitor nano delivery signaling pathway

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