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Comparison of safety and efficacy between fondaparinux and nadroparin in non-ST elevation acute coronary syndromes

Chinese Medical Journal 2011年第6期124卷 879-886页

作者： YAN Hong-bing SONG Li LIU Ran ZHAO Han-jun WANG Shao-pin CHI Yun-peng ZHENG Bin LI Wen-zheng LIU Chen ZHOU Peng Cardiovascular Institute and Fuwai Hospital Peking Union Medical College and Chinese Academy of Medical SciencesBeijing 100037 China Beijing Anzhen Hospital Capital Medical University Beijing 100029 China

Background American College of Cardiology/American Heart Association/European Society of Cardiology （ACC/AHA/ESC） guidelines gave fondaparinux a class Ⅰ recommendation for use in patients with non-ST elevation acute coronary syndromes （NSTE-ACS） undergoing invasive or conservative strategy. nadroparin is one of the common anticoagulants used in NSTE-ACS in China. Accordingly, this study compared the safety and efficacy between fondaparinux and nadroparin in patients with *** In this prospective, randomized, open-label, and single center study, a total of 300 patients with NSTE-ACS were randomized to receive either fondaparinux （group F, n=150, 2.5 mg/d） or nadroparin （group N, n=150, 0.1 ml/10 kgq12 h） for a mean of 4 days. The primary safety endpoint was the incidence of major or minor bleeding at 9 days that was not related to coronary artery bypass grafting （CABG）. The primary efficacy endpoints included death, myocardial infarction, or recurrent ischemia at 9 days. All patients underwent a 180-day *** Baseline characteristics were well matched between the two groups. There was a non-significant 28% relative risk reduction in the primary safety endpoint in group F compared with group N （4.7% vs. 6.7%, HR 0.72, 95% CI0.42-1.65, P=0.38）. The primary efficacy endpoint was 8.0% in group F and 10.0% in group N （HR, 0.82, 95% CI0.54-1.71, P=0.49）. The composite of the safety and efficacy endpoints at 9 days （10.0% vs. 16.0%, HR 0.61, 95% CI0.31-1.10,P=0.10）, 30 days （14.0% vs. 17.9%, HR 0.72, 95% C/0.47-1.16, P=0.21）, or 180 days （18.7% vs. 27.3%, HR0.65, 95% CI0.38-1.11, P=0.11） showed a non-significant trend toward a lower value in group *** Fondaparinux resulted in a nonsignificant risk reduction in patients with NSTE-ACS in both bleeding and ischaemic events during short- and long-term follow-up compared with nadroparin.

关键词： anticoagulants fondaparinux nadroparin acute coronary syndromes

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Effect of danhong injection combined with nadroparin calcium on serum CyS-C, CRP, IL-6, vWF, ET and VEGF in patients with acute coronary syndrome

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Journal of Hainan Medical University 2017年第16期23卷 5-8页

作者： Xun-Jian Hu Ming-Zhe Zhao Zhong-Qi Wu Hui-Ying Huai Department of Cardiology the Third People's Hospital of JiangsuJiangyin214442 China

Objective: To study the effect of danhong injection combined with nadroparin calcium on serum CyS-C, CRP, IL-6, vWF, ET and VEGF in patients with acute coronary syndrome. Methods: A total of 80 patients with acute coronary syndrome in our hospital from July 2014 to July 2017 were enrolled in this study. The subjects were divided into the control group (n=40) and the treatment group (n=40) randomly. The control group was treated with xuesaitong injection combined with nadroparin calcium;the treatment group was treated with danhong injection combined with nadroparin calcium. The two groups were treated for 2 weeks. The serum CyS-C, CRP, IL-6, vWF, ET and VEGF levels of the two groups before and after treatment were compared. Results: There were no significantly differences of the serum CyS-C, CRP, IL-6, vWF, ET and VEGF levels of the two groups before treatment. The serum CyS-C, CRP, IL-6, vWF, ET and VEGF levels of the two groups after treatment were significantly lower than before treatment, and that of the treatment group were significantly better than that of the control group. Conclusion: Danhong injection combined with nadroparin calcium can significantly reduce the serum CyS-C, CRP, IL-6, vWF, ET and VEGF levels of patients with acute coronary syndrome, and it was worthy clinical application.

关键词： Danhong injection nadroparin calcium Acute coronary syndrome CyS-C CRP IL-6 vWF ET VEGF

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颅内手术后早期应用nadroparin颅内出血风险的前瞻性研究

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中国微侵袭神经外科杂志 2003年第10期8卷 468-468页

作者：白红民

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Spontaneous retroperitoneal hemorrhage after hemodialysis involving anticoagulant agents

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第5期13卷 408-412页

作者： Wen-xing FAN Zheng-xu DENG Fang LIU Rong-bo LIU Ling HE Bogati AMRIT Li ZANG Jing-wen LI Xian-rong LIU Song-min HUANG Ping FU Department of Nephrology West China HospitalSichuan UniversityChengdu 610041China Department of Radiology West China Hospital Sichuan University Chengdu 610041China

In this paper, we described the symptoms and treatment of a patient with diabetic nephropathy accom- panied by spontaneous retroperitoneal hemorrhage after hemodialysis. An elderly female patient with diabetic neph- ropathy presented with severe pain, numbness, and an increasing swelling in the left hip and left thigh after six ses- sions of hemodialysis involving the use of an antiplatelet drug and an anticoagulant agent. Her hemoglobin decreased to 46 g/L. An abdominal ultrasound showed a hematoma in the left retroperitoneal space, and computed tomography (CT) findings revealed a 6 cm×8 cm×10 cm hematoma in the left psoas muscle. After aggressive supportive therapy [the administration of packed red blood cell transfusion, carbazochrome sodium sulfonate injection, and continuous venovenous hemofiltration (CVVH)], the patient's vital signs stabilized and her hemoglobin increased to 86 g/L. Repeat CT showed that the hematoma had been partially absorbed after two weeks. Eventually, the patient was discharged with stable vital signs. Physicians should be aware of the possibility of spontaneous retroperitoneal hemorrhage, particularly in patients with diabetic nephropathy undergoing hemodialysis involving the use of anticoagulant agents.

关键词： Spontaneous retroperitoneal hemorrhage Diabetic nephropathy Hemodialysis nadroparin calcium

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