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myrrh extract alleviated ROS-mediated ferroptosis through regulating TXNIP/NLRP3 axis in ischemic stroke

中国药理学与毒理学杂志 2019年第9期33卷 667-668页

作者： LIU Tian-long WANG Wen-jun DING Yi WEN Ai-dong ZHANG Ru-xue Department of Pharmacy Key Laboratory of Prevention and Cure for the Plateau Environmental Damage of PLA940 Hospital of PLA Joint Logistics Support ForcesLanzhou 730050China Department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi′an 710032China

OBJECTIVE To investigate the neuroprotective effects and exact mechanisms of myrrh extract following cerebral ischemic stroke.METHODS Male rats were randomly divided into three groups:sham group,middle cerebral artery occlusion(MCAO)group and myrrh group.Morphological changes were assessed after 7 d of myrrh treatment.Microarray analysis with circulating mRNA was performed to identify differential gene expression profile,gene ontology and pathway enrichment analyses were carried out to predict the gene function.Gene co-expression and pathway networks were constructed to identify the potential targets.The markers of oxidative stress,inflammatory reaction and ferroptosis in the cerebral cortex were detected by ELISA assays.The identified hub pathways and genes were validated by western blotting,immunofluorescence and immunohistochemistry analyses.Neurons were exposed to transient oxygen-glucose deprivation(OGD)to model ischemia-like conditions.siRNA-TXNIP were transfected in OGD-induced neurons to explore the mechanism.RESULTS myrrh extract significantly alleviated neurological deficits,infarct volume and histo⁃pathological damage in MCAO rats.A total of 2200 differentially expressed genes were identified among the three groups.Oxidation-reduction process,inflammatory response,ferroptosis were enriched as the significant gene ontology items.NOD-like receptor signaling were identified as the hub pathway based on the pathway relation network.TXNIP and NLRP3 were screened as the potential targets by a time sequence profile analysis.The levels of IL-1β,IL-18,TNF-α,MDA and TFR in brain tissues were increased while the CAT,SOD,GSH-px and GPX4 levels were significantly decreased in MCAO group.As expected,myrrh extract greatly reversed these changes.The similarly results were also observed in OGD treated neuron cells.The elevated expressions of TXNIP and NLRP3 induced by OGD were success⁃fully inhibited by myrrh treatment.Knockdown of TXNIP significantly alleviated OGD-induced ROS accumulation and oxidative stress,but the

关键词： myrrh extract ischemic stroke ferroptosis NLRP3 inflammasome thioredoxin-interacting protein reac⁃tive oxygen species

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Antiulcer Activities of Commiphora molmol (myrrh) extract in Male Rats

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Open Journal of Gastroenterology 2016年第10期6卷 300-309页

作者： Nehal A. A. Alfky Reham A. Mustafa Eslam A. Header Naser A. El Sawy Abdullah G. Al-Kushi Clinical Nutrition Department Faculty of Applied Medical Sciences Umm Al Qura University Mecca KSA Department of Nutrition and Food Science Faculty of Home Economics Minufiya University Monufia Governorate Egypt Laboratory Medicine Department Faculty of Applied Medical Sciences Umm Al Qura University Mecca KSA Department of Anatomy and Embryology Faculty of Medicine Zagazig University Ismailia Egypt Department of Anatomy Faculty of Medicine Umm Al Qura University Mecca KSA

Medicinal plants used in folk medicine contain a wide range of substances that can prevent and treat many diseases. The Antiulcer Activities effects of myrrh or Commiphora molmol extract (CME) were assessed in rats. In this experiment, thirty rats were divided into 6 groups as follows: G1) normal control (vehicle);G2) received aspirin without any treatment;G3) pretreated with Omeprazole (antiulcer drug) and groups (4), (5) and (6) were pretreated with CME at 125, 250 and 500 mg/kg b.wt, respective-ly for 2 weeks. At the end of experiment the volume, pH and total acidity of gastric juices;mucus content and ulcer lengths were measured and protection percentages were calculated. Gross and histopathological examinations of stomachs were also performed. CME induced an antiulcer effect manifested by decreased volume and total acidity of gastric juice and increased mucus content and percentages of protec-tion from ulcer as well as partial amelioration of gross and histopathological lesions seen in stomach of ulcerated rats. In conclusion, the results denote that Commiphora molmol extract possess antiulcer effects in rats. These results affirm the traditional use of myrrh extract for the treatment of gastric ulcer.

关键词： Commiphora molmol myrrh extract Antiulcer Gastric Juices Omeprazole

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