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Protective Mechanisms of Suxiao Jiuxin Pills(速效救心丸) on myocardial ischemia-reperfusion injury in vivo and in vitro

Chinese Journal of Integrative Medicine 2020年第8期26卷 583-590页

作者： TAN Ya-fang YU Juan PAN Wen-jun QI Jian-yong ZHANG Min-zhou AMI Key Laboratory of Chinese Medicine in Guangzhou Guangdong Province Hospital of Chinese Medicinethe 2nd Affiliated Hospital of Guangzhou University of Chinese MedicineGuangdong Provincial Academy of Chinese Medical ScienceGuangzhou 510006China Intensive Care Research Team of Traditional Chinese Medicine Guangdong Province Hospital of Chinese Medicinethe 2nd Affiliated Hospital of Guangzhou University of Chinese MedicineGuangdong Provincial Academy of Chinese Medical ScienceGuangzhou 510006China Animal Laboratory Guangdong Province Hospital of Chinese MedicineGuangzhou 510006China

Objective:To study the protective mechanism of Chinese medicine Suxiao Jiuxin Pills(速效救心丸,SXJ)on myocardial ischemia and reperfusion(I/R)injury.Methods:Mouse myocardial I/R injury model was created by 30-min coronary artery occlusion followed by 24-h reperfusion,the mice were then divided into the sham group(n=7),the I/R group(n=13),the tirofiban group(TIR,positive drug treatment,n=9),and the SXJ group(n=11).Infarct size(IS),risk region(RR),and left ventricle(LV)were analyzed with double staining methods.In addition,H9C2 rat cardiomyocytes were cultured with Na2S2O4 to simulate I/R in vitro.The phosphorylation of extracellular regulated protein kinases1/2(ERK1/2),protein kinase B(AKT),glycogen synthase kinase-3β(GSK3β),and protein expression of GATA4 in nucleus were detected with Western blot assay.Results:The ratio of IS/RR in SXJ and TIR groups were lower than that in I/R group(SXJ,22.4%±6.6%;TIR,20.8%±3.3%;vs.I/R,35.4%±3.7%,Pmyocardial I/R injury in mice by activating AKT/GSK3βand GATA4 signaling pathways.

关键词： myocardial ischemia and reperfusion injury Suxiao Jiuxin Pills GATA4 Chinese medicine mouse

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