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Effects of TanshinoneⅡA on the myocardial hypertrophy Signal Transduction System Protein Kinase B in Rats

Chinese Journal of Integrative Medicine 2009年第5期15卷 365-370页

作者：屠恩远周亚光王照华梁黔生杨光田 Department of Emergency Tongji HospitalTongji CollegeHuazhong University of Science and Technology

Objective： To study the effect of tanshinone ⅡA on the cell signal transduction system protein kinase B （Akt） in rats with hypertrophy of the myocardium induced by partial constriction of the thoracic aorta. Methods： Rat models of myocardial hypertrophy were established by the thoracic aorta partial constriction method. Forty-eight rats were randomly divided into the sham-operative group, the model group, the valsartan treatment group, and the low-, medium-, and high-dose tanshinone treatment groups. The heart mass index （HMI）, left ventricular mass index （LVMI）, ejection fraction （EF）, left ventricular posterior wall （LVPW）, and interventricular septal thickness （IVS） were detected by high-frequency ultrasonography. The myocardial fiber diameter （MFD） was detected by HE staining, and the contents of p-Akt and p-Gsk3β in the myocardium were detected by Western blot. Results： Compared with the sham-operative group, the levels of HMI, LVMI, LVPW, IVS, and MFD were increased respectively in the other groups （P〈0.05）; the contents of p-Akt and p-Gsk3β were also increased in the other groups. Compared with the model group, the levels of HMI, LVMI, LVPW, IVS, and MFD were decreased respectively in all treatment groups （P〈0.05）; the contents of p-Akt and p-Gsk3β were decreased in all treatment groups as well. There was no significant difference, however, among the low-, medium-, and high-dose tanshinone treatment groups and the valsartan treatment group （P〉0.05）. Conclusion： Tanshinone HE A can prevent myocardial hypertrophy by its action on the protein kinase B （Akt） signaling pathway.

关键词： tanshinone ⅡA myocardial hypertrophy rat protein kinase B thoracic aorta coarctation

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Protective effect of tanshinone Ⅱ A on signal transduction system protein kinase B in rats with myocardial hypertrophy

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Frontiers of Medicine 2009年第4期3卷 431-436页

作者： Enyuan TU Yongjun PAN Kang ZHENG Zhaohua WANG Qiansheng LIANG Guangtian YANG Department of Emergency Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

The effects of tanshinone II A on cell signal transduction system protein kinase B in rats with myocardial hypertrophy induced by the abdominal aorta partial coarctation were *** models of myocardial hypertrophy were established by using abdom-inal aorta partial coarctation ***-eight rats were randomly divided into sham group(S group),model group(M group),valsartan treatment group(X group),low-dose tanshinone treatment group(LD group),medium-dose tanshinone treatment group(MD group),and high-dose tanshinone treatment group(HD group)(n=8 in each group).Left ventricular mass index(LVMI),left ventri-cular posterior wall(LVPW),and septal thickness(IVS)were detected by high frequency ***ﬁber diameter(MFD)was examined by Hematoxylin-Eosin(HE)staining,and the contents of phosphorylated protein kinase B(p-Akt)and p-Gsk3βin myocardium were assayed by Western *** results showed that compared with S group,the values of LVMI,LVPW,IVS and MFD were increased in other groups(P0.05),and there were no signiﬁcant differences between X group and tanshinone treatment groups(P>0.05).It was suggested that tanshinone II A could prevent myocardial hypertrophy by its action on the Akt signaling pathway.

关键词： tanshinoneⅡA myocardial hypertrophy rat protein kinase B abdominal aorta coarctation

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Effect of Yiqi Huoxue Recipe(益气活血方)on Cardiac Function and Ultrastructure in Regression of Pressure Overload-induced myocardial hypertrophy in Rats

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Chinese Journal of Integrative Medicine 2007年第4期13卷 291-296页

作者：佟长青邸瑶刘子泉王义和何炜代二庆 Department of Physiology Medical College of the Chinese People's Armed Police Forces Department of Traditional Chinese Medicine Medical College of the Chinese Deople's Armed Police Forces

Objective： To investigate the effect of Yiqi Huoxue Recipe （YHR, 益气活血方） on the cardiac function and ultrastructure during the regression of myocardial hypertrophy induced by pressure overload in rats. Methods： The model of myocardial hypertrophy was established by abdominal aortic banding. Eighty male Wistar rats were divided into six groups, the normal control group Ⅰ （n=20）, the normal control group Ⅱ（n=12）, the hypertension model group Ⅰ （n=12）, the hypertension model group Ⅱ （n=12）, the YHR group （n=12） and the Captopril group （n=12）. The observation was carried out in the normal control group Ⅰ and the hypertension model groupⅠ after 4 weeks of modeling, and the other four groups were observed after 16 weeks of modeling （12 weeks of administration）. The cardiac function was measured with a multichannel biological signal analysis system, and the myocardium ultrastructure was observed by a transmission electron microscope. Results：（1） Compared with the normal control group Ⅰ, the systolic blood pressure and cardiac coefficient （left ventricular weight/body weight） in the model Ⅰ group was higher （P〈0.05, P〈0.01）. （2） In the YHR group, cardiac coefficient and -dp/dtmax were lower, left ventricular systolic pressure and ＋dp/dtmin were higher when compared with the model group Ⅱ and the Captopril group （P〈0.05 or P〈0.01）. In the Captopril group, only cardiac coefficient was lower when compared with the mode group Ⅱ （P〈0.05）. （3） Compared with the normal control group Ⅱ, ＋dp/dtmax was higher （P〈0.01）, -dp/dtmax and isovolumetric contraction time （ICT） was lower （P〈0.05, P〈0.01） in both the YHR group and the Captopril group. （4） Results of the myocardium ultrastructure showed edema under myocardium plasmalemma, enlarged sarcoplasmic reticulum and T tube, and significantly enlarged intercalated disc of the cardiac muscle in the model groups. In the Captopril group, the extension of sarcoplasmic reticulum and T tube as well as the pathological changes of intercalated d

关键词： traditional Chinese herbs therapy myocardial hypertrophy regression cardiac function ultrastructure pressure overload rats

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Alterations in Cardiac Structure and Function in a Modified Rat Model of myocardial hypertrophy

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2014年第5期34卷 626-633页

作者：戴文军董颀陈敏生赵路宁陈爱兰黎镇赐刘世明 Department of Cardiology The Second Affiliated Hospital of Guangzhou Medical University Guangzhou Institute of Cardiovascular Disease Department of Physiology Guangzhou Medical University Department of Medical Experimental Center Guangzhou Medical University Department of Cardiology The First Affiliated Hospital of Guangzhou Medical University Department of Cardiology The First Municipal People’s Hospital of GuangzhouGuangzhou Medical College

This study was aimed to establish a stable animal model of left ventricular hypertrophy （LVH） to provide theoretical and experimental basis for understanding the development of LVH. The abdominal aorta of male Wistar rats （80-100 g） was constricted to a diameter of 0.55 mm between the branches of the celiac and anterior mesenteric arteries. Echocardiography using a linear phased array probe was performed as well as pathological examination and plasma B-type natriuretic peptide （BNP） measurement at 3, 4 and 6 weeks after abdominal aortic constriction （AAC）. The results showed that the acute mortality rate （within 24 h） of this modified rat model was 8%. Animals who underwent AAC demonstrated significantly increased interventricular septal （IVS）, LV posterior wall （LVPWd）, LV mass index （LVMI）, cross-sectional area （CSA） of myocytes, and perivascular fibrosis; the ejection fraction （EF）, fractional shortening （FS）, and cardiac output （CO） were consistently lower at each time point after AAC. Notably, differences in these parameters between AAC group and sham group were significant by 3 weeks and reached peaks at 4th week. Following AAC, the plasma BNP was gradually elevated compared with the sham group at 3rd and 6th week. It was concluded that this modified AAC model can develop LVH, both stably and safely, by week four post-surgery; echocardiography is able to assess changes in chamber dimensions and systolic properties accurately in rats with LVH.

关键词： abdominal aortic constriction myocardial hypertrophy echocardiography rat

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Effects of Anthopleurin-Q on myocardial hypertrophy in rats and isolated atria in guinea pigs

Effects of Anthopleurin-Q on myocardial hypertrophy in rats ...

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2002全国青年药理学英文学术会议

作者： Zhou Ji, Fu Li-Ying, Yao Wei-Xing, Jiang MingxingPharmacology Department, Tongji Medical School, Huazhong University of Technologyand Science, Wuhan 430030

AIM: To study effects of Anthopleurin-Q (AP-Q), a polypeptide of marine origin, on myocardial hypertrophy in rats and isolated atria in guinea pigs. METHODS: Two myocardial hypertrophy models in rats were established, one introduced by levothyroxine, the other by stenosis of abdominal aorta. Morphometry of cardiac myocytes and functional experiments were employed to investigate effects of AP-Q. Results: 1. In both rat models, notable decreases in morphologic parameters of cardiomyocytes (cell area, perimeter, average diameter, maximum diameter, and minimum diameter) were noted in low-dose

关键词： Anthopleurin myocardial hypertrophy atria of guinea pig

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Inhibitory effect of sodium ferulate on myocardial hypertrophy in SHR

Inhibitory effect of sodium ferulate on myocardial hypertrop...

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首届东方药理论坛暨2018年全国心脑血管药理学术会议、上海市药理学会第十九届学术年会

作者： Pan-pan Chen Lu Yang Min Luo Jiang Deng Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education Zunyi Medical University

Sodium ferulate is sodium salt of ferulic acid which is one of the active ingredients in Radix Angelica Sinensis and Ligusticum chuanxiong *** research investigated whether sodium ferulate can inhibit myocardial hypertrophy in ***-week-old male SHR were randomly divided into model group(SHR) and sodium ferulate(20,40,and 80 mg/kg/day).The normal male wisttar-kyoto rats(WKY) of 14 weeks old were randomly divided into normal group and normal administration of sodium ferulate 80 mg/kg/day, wky group).There are 10 animals in each group once a day for 12 *** myocardial hypertrophy was proved by the elevated myocardial hypertrophic parameters,histopathology,changes of cardiac function and left ventricular wall thickness and the gene expression of atrial natriuretic factor(ANF,a gene related to myocardial hypertrophy).Sodium ferulate can significantly improve cardiac function and related indexes of myocardial hypertrophy in SHR,including histopathology and anf gene ***,we observed the concentration of angiotensin II(Ang II) and endothelin-1(ET-1) in *** Ang II and ET-1 were significantly increased in myocardium of SHR,and sodium ferulate could reduce the Ang II and *** results suggest that sodium ferulate could alleviate myocardial hypertrophy in SHR.

关键词： Sodium ferulate myocardial hypertrophy SHR

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The antioxidation and anti-inflammation effect of genistein on myocardial hypertrophy rats induced by Iso

The antioxidation and anti-inflammation effect of genistein ...

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2012国际生理学学术大会

作者： Xinming Zhong Wa Yuan Hai Xiao Liangdong Li Zhihua Huang Jing Zeng The first affiliated hospital of Gannan medical college Department of Physiology Gannan medical college Department of Pharmacology Gannan Medical College

＜正＞To observe the antioxidation and anti-inflammation effect of Genistein（Gen） on rat’s myocardial hypertrophy caused by isopropylarterenol（Iso）.Methods:The myocardial hypertrophy model was formed through hypodermic injection *** rats were administrated with various doses of Gen,DMSO or normal saline through hypodermic injection from the second day after Iso treated,and the process extended 14 *** the last administration,the indexes of left ventricle was calculated,the activity of superoxide dismutase（SOD）, myeloperoxidase（MPO） and the concentration of malondialdehyde（MDA） in serum and interleukin-2（IL-2） in myocardial tissue were ***:In Gen groups,the left ventricle index was depressed significantly,the activity of SOD was increased while the content of MDA and the activity of MPO in the serum were decreased markedly,and the level of IL-2 in myocardial tissue of rats was ***:Gen has antioxidation and anti-inflammation effect on the myocardial hypertrophy caused by Iso.

关键词： Genistein myocardial hypertrophy antioxidation anti-inflammation effect

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Effects of electroacupuncture at "Nèiguān" (内关 PC6) on the catecholamine neurotransmitters of rats with myocardial hypertrophy

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World Journal of Acupuncture-Moxibustion 2011年第4期21卷 32-36页

作者：李佳吴松洪亚群黄伟吴绪平陈泽斌王华湖北中医药大学针灸骨伤学院

Objective To study the neuroendocrine mechanisms of electroacupuncture （EA） at ＂Neiguan＂（内关 PC 6） for preventing and treating myocardial hypertrophy. Methods Thirty 3-month-old Sprague-Dawley rats were randomly divided into a normal group, a model group and an EA group according to the random digit table, 10 in each group. Isoprenaline Hydrochloride （ISO） injection was subcutaneously injected to establish the model. EA at ＂Neiguan＂（内关 PC 6） was applied for rats in the EA group, 20 min each time, once daily, for 14 successive days. No treatment was given to rats in the normal group and the observed. The plasma catecholamine neurotransmitters levels and c determined with high performance liquid chromatography model group. The electrocardiogram （ECG） was hanges of their metabolic products contents were （HLPC） method. Results Compared with the normal group, catecholamine neurotransmitters, such as epinephrin （E）, norepinephrine （NE）, and dopamine （DA） and metabolic products, such as 3-methoxy-4-hydroxyphenylglycol （MHPG）, homovanillic acid （HVA）, and 3,4-dihydroxy-phenyl acetic acid （DOPAC） were significantly increased in the model group （all P〈0.05）. These parameters decreased in the EA group when compared with the model group （all P〈0.05）. Conclusion EA at ＂Neiguan＂（内关 PC 6） could improve the myocardial hypertrophy, which might be correlated with the neuroendocrine system.

关键词： myocardial hypertrophy Point PC 6 (Neiguan) Neuroendocrine

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Depletion of Kindlin-2 induces cardiac dysfunction in mice

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Science China(Life Sciences) 2016年第11期59卷 1123-1130页

作者： Lihua Qi Yu Yu Xiaochun Chi Danyu Lu Yao Song Youyi Zhang Hongquan Zhang Department of Human Anatomy Histology and Embryology and Key Laboratory of Carcinogenesis and Translational Research Ministry of Education Peking University Health Science and State Key Laboratory of Natural and Biomimetic Drugs Peking University Health Science Center Institute of Vascular Medicine Peking University Third Hospital and Key Laboratory of Molecular Cardiovascular Sciences Ministry of Education Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides Ministry of Health Peking University Health Science

Kindlin-2, a member of the Kindlin family focal adhesion proteins, plays an important role in cardiac development. It is known that defects in the Z-disc proteins lead to hypertrophic cardiomyopathy(HCM) or dilated cardiomyopathy(DCM). Our previous investigation showed that Kindlin-2 is mainly localized at the Z-disc and depletion of Kindlin-2 disrupts the structure of the Z-Disc. Here, we reported that depletion of Kindlin-2 leads to the disordered myocardial fibers, fractured and vacuolar degeneration in myocardial fibers. Interestingly, depletion of Kindlin-2 in mice induced cardiac myocyte hypertrophy and increased the heart weight. Furthermore, decreased expression of Kindlin-2 led to cardiac dysfunction and also markedly impairs systolic function. Our data indicated that Kindlin-2 not only maintains the cardiac structure but also is required for cardiac function.

关键词： Kindlin-2 depletion myocardial hypertrophy cardiac dysfunction mouse

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Effects of Calmodulin-dependent Protein Kinase Ⅱ Inhibitor,KN-93,on Electrophysiological Features of Rabbit Hypertrophic Cardiac Myocytes

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2012年第4期32卷 485-489页

作者：柯俊陈锋张存泰肖幸涂晶戴木森王晓萍陈兵陈敏 Department of Emergency Fujian Provincial HospitalProvincial College of Clinical MedicineFujian Medical University General Department Tongji HospitalTongji Medical CollegeHuazhong University of Science and Technology

Cardiac hypertrophy is an independent risk factor for sudden cardiac death in clinical settings and the incidence of sudden cardiac death and ventricular arrhythmias are closely *** aim of this study was to determine the effects of the calmodulin-dependent protein kinase(CaMK) Ⅱ inhibitor,KN-93,on L-type calcium current(I Ca,L) and early after-depolarizations(EADs) in hypertrophic cardiomyocytes.A rabbit model of myocardial hypertrophy was constructed through abdominal aortic coarctation(LVH group).The control group(sham group) received a sham operation,in which the abdominal aortic was dissected but not *** weeks later,the degree of left ventricular hypertrophy(LVH) was evaluated using *** cardiomyocyte was isolated through collagenase *** potentials(APs) and I Ca,L were recorded using the perforated patch clamp *** were recorded under current clamp conditions and I Ca,L was recorded under voltage clamp *** incidence of EADs and I ca,L in the hypertrophic cardiomyocytes were observed under the conditions of low potassium(2 mmol/L),low magnesium(0.25 mmol/L) Tyrode’s solution perfusion,and slow frequency(0.25-0.5 Hz) electrical *** incidence of EADs and I ca,L in the hypertrophic cardiomyocytes were also evaluated after treatment with different concentrations of KN-92(KN-92 group) and KN-93(KN-93 group).Eight weeks later,the model was successfully *** the conditions of low potassium,low magnesium Tyrode’s solution perfusion,and slow frequency electrical stimulation,the incidence of EADs was 0/12,11/12,10/12,and 5/12 in sham group,LVH group,KN-92 group(0.5 μmol/L),and KN-93 group(0.5 μmol/L),*** the drug concentration was increased to 1 μmol/L in KN-92 group and KN-93 group,the incidence of EADs was 10/12 and 2/12,*** 0 mV,the current density was 6.7±1.0 and 6.3±0.7 PA·PF-1 in LVH group and sham group,respectively(P>0.05,n=12).When the drug

关键词： calmodulin-dependent protein kinase Ⅱ KN-93 myocardial hypertrophy electrophysiology perforated patch recording techniques

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