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Vitamin A regulates mitochondrial biogenesis and function through p38 MAPK‑PGC‑1α signaling pathway and alters the muscle fiber composition of sheep

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Journal of Animal Science and Biotechnology 2024年第2期15卷 898-910页

作者： Pengkang Song Jiamin Zhao Fanqinyu Li Xiaoyi Zhao Jinxin Feng Yuan Su Bo Wang Junxing Zhao College of Animal Science Shanxi Agricultural UniversityTaiguShanxi 030801People’s Republic of China State Key Laboratory of Animal Nutrition and Feeding Department of Animal Nutrition and Feed ScienceCollege of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193People’s Republic of China

Background Vitamin A(VA)and its metabolite,retinoic acid(RA),are of great interest for their wide range of physiological ***,the regulatory contribution of VA to mitochondrial and muscle fiber composition in sheep has not been *** Lambs were injected with 0(control)or 7,500 IU VA palmitate into the biceps femoris muscle on d 2 after *** the age of 3 and 32 weeks,longissimus dorsi(LD)muscle samples were obtained to explore the effect of VA on myofiber type *** vitro,we investigated the effects of RA on myofiber type composition and intrinsic *** The proportion of type I myofiber was greatly increased in VA-treated sheep in LD muscle at *** greatly promoted mitochondrial biogenesis and function in LD muscle of *** exploration revealed that VA elevated PGC-1αmRNA and protein contents,and enhanced the level of p38 MAPK phosphorylation in LD muscle of *** addition,the number of type I myofibers with RA treatment was significantly increased,and type IIx myofibers was significantly decreased in primary *** with in vivo experiment,RA significantly improved mitochondrial biogenesis and function in primary myoblasts of *** then used si-PGC-1αto inhibit PGC-1αexpression and found that si-PGC-1αsignificantly abrogated RA-induced the formation of type I myofibers,mitochondrial biogenesis,MitoTracker staining intensity,UQCRC1 and ATP5A1 expression,SDH activity,and enhanced the level of type IIx muscle *** data suggested that RA improved mitochondrial biogenesis and function by promoting PGC-1αexpression,and increased type I *** order to prove that the effect of RA on the level of PGC-1αis caused by p38 MAPK signaling,we inhibited the p38 MAPK signaling using a p38 MAPK inhibitor,which significantly reduced RA-induced PGC-1αand MyHC I *** VA promoted PGC-1αexpression through the p38 MAPK signaling pathway,improved mitochondrial biogenesis,and altered

关键词： Mitochondria muscle fiber type PGC-1α p38 MAPK Retinoic acid Vitamin A

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Targeted myostatin loss-of-function mutation increases type Ⅱ muscle fibers in Meishan pigs

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Journal of Integrative Agriculture 2022年第1期21卷 188-198页

作者： QIAN Li-li XIE Jing-yi GAO Ting CAI Chun-bo JIANG Sheng-wang BI Han-fang XIE Shan-shan CUI Wen-tao Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityQingdao UniversityQingdao 266021P.R.China Institute of Animal Sciences Chinese Academy of Agricultural SciencesBeijing 100193P.R.China College of Animal Medicine China Agricultural UniversityBeijing 100193P.R.China

Myostatin(MSTN) is a negative regulator of skeletal muscle growth and development. The skeletal muscle in MSTN^(-/-)mice is significantly hypertrophied, with muscle fiber type II increasing significantly while muscle fiber type I ***, it is still not clear how the skeletal muscle types change in MSTN^(-/-)pigs, and how the mechanism for MSTN regulates fiber types, especially in large animals like pigs. This study conducted a comprehensive analysis of the composition of skeletal muscle fibers in MSTN^(-/-)pigs produced in our laboratory. It was observed that, compared with wild-type(WT) pigs, both the total mass of skeletal muscle and type IIb muscle fibers increased significantly(Ptype I and type IIa muscle fibers decreased significantly(Pmuscle fiber type and its regulation mechanism in the embryonic stage, this study selected a few genes(Myf5, Mef2 d, MyoD and Six1) associated with muscle fiber type and validated their expression by quantitative RT-PCR. Herein, it was found that Myh7, Myh2, Myh4 and Myh1 can be detected in the skeletal muscle of pigs at 65 days of gestation(dg). Compared with WT pigs, in MSTN^(-/-)Meishan pigs, Myh7 decreased significantly(Pmuscle fiber types in the early stage of embryonic development. Thus, at the embryonic stage, the type II muscle fibers began to increase in MSTN^(-/-)pigs. These results can provide valuable information not only for pig meat quality improvement, but also for the study of human skeletal muscle development and disease treatment.

关键词： MSTN Meishan pigs muscle fiber type muscle fiber development

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Nerve Growth Factor Promotes Angiogenesis and Skeletal muscle fiber Remodeling in a Murine Model of Hindlimb Ischemia

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Chinese Medical Journal 2016年第3期129卷 313-319页

作者： Yong-Peng Diao Feng-Kui Cui Sheng Yan Zuo-Guan Chen Li-Shan Lian Li-Long Guo Yong-Jun Li Department of Vascular Surgery Beijing Shijitan Hospital Capital Medical University Beijing 100038 China Department of Vascular Surgery Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Science Beijing 100730 China Department of Vascular Surgery Daqing Oilfield General Hospital Heilongjiang 163001 China

Background： Therapeutic angiogenesis has been shown to promote blood vessel growth and improve tissue *** growth factor （NGF） has been reported to play an important role in both physiological and pathological *** study aimed to investigate the effects of NGF on angiogenesis and skeletal muscle fiber remodeling in a murine model of hindlimb ischemia and study the relationship between NGF and vascular endothelial growth factor （VEGF） in ***： Twenty-four mice were randomly allocated to normal control group （n =6）, blank control group （n =6）, VEGF gene transfection group （n =6）, and NGF gene transfection group （n =6）.The model of left hindlimb ischemia model was established by ligating the femoral ***165 plasmid （125 μg） and NGF plasmid （125 μg） was injected into the ischemic gastrocnemius of mice from VEGF group and NGF group, *** hindlimb function and ischemic damage were assessed with terminal points at 21th day postischemia *** gastrocnemius of four groups was tested by hematoxylin-eosin staining, proliferating cell nuclear antigen and CD34 immunohistochemistry staining, and myosin ATPase *** and VEGF protein expression was detected by enzyme-linked immunosorbent ***： On the 21th day after surgery, the functional assessment score and skeletal muscle atrophy degree of VEGF group and NGF group were significantly lower than those of normal control group and blank control *** endothelial cell proliferation index and the capillary density of VEGF group and NGF group were significantly increased compared with normal control group and blank control group （P 〈 0.05）.The NGF and VEGF protein expression of NGF group showed a significant rise when compared with blank control group （P 〈 0.05）.Similarly, the VEGF protein expression of VEGF group was significantly higher than that of blank control group （P 〈 0.05）, but there was no significant difference of the NGF protein expressi

关键词： Angiogenesis Limb lschemia muscle fiber type Nerve Growth Factor Vascular Endothelial Growth Factor

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质疑与思考：运动生理学研究的十个问题

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体育 2021年第6期

作者：汪军周越孙君志于亮徐玉明张学林张日辉李顺昌黄文英夏志赵广高黎涌明胡敏田振军苏全生张勇王瑞元

随着科学技术的发展和时代的进步，运动生理学也日新月异，一些老的议题也有了新的阐释和理解。本文就运动生理学发展过程中出现的一些经典议题给予了新的理解和梳理：肌纤维类型能否改变、延迟性肌肉酸痛的原因辨析、运动员心脏的争议... 详细信息

随着科学技术的发展和时代的进步，运动生理学也日新月异，一些老的议题也有了新的阐释和理解。本文就运动生理学发展过程中出现的一些经典议题给予了新的理解和梳理：肌纤维类型能否改变、延迟性肌肉酸痛的原因辨析、运动员心脏的争议和发展、肌肉因子在运动与免疫中的作用、最大摄氧量的限制因素之争、无氧阈出现的真正原因、疲劳的中枢和外周机制、衰老与肌萎缩、运动是良医等。最后，对当前运动生理学的历史发展机遇进行了阐述，认为当前运动生理学的发展更应该注重实践性以及运动中的人。文章期望为未来运动生理学的发展和科学研究提供新的思路。

关键词：运动生理学肌纤维类型延迟性肌肉酸痛运动员心脏运动与免疫最大摄氧量疲劳肌肉萎缩运动是良医 exercise physiology muscle fiber type delayed onset muscle soreness athletes heart exercise and immunity maximum oxygen uptake fatigue muscle atrophy exercise is medicine

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《解剖学报》投稿须知的补充

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解剖学报 1994年第2期 115+118-115+118页

作者： Li Zhi-yi Li Ming-Yang Xue Qian Ying Fu-qi Liu Shao-zhuang (Department of Anatomy,Zunyi Medical College,Zunyi Department of Anatommy,Dalian Medical College,Dalian)

《解剖学报》投稿须知的补充８．废弃体积克分子浓度“Ｍ”。换算：１Ｍ＝１ｍｏｌ／Ｌｍ＝１ｋｍｏｌ／ｍ３废弃当量浓度“Ｎ”。换算：１Ｎ＝（１ｍｏｌ／Ｌ）÷离子价数９．暂时可与ＳＩ（国际单位制）并用的非法定计量单位如埃（Ａ... 详细信息

《解剖学报》投稿须知的补充８．废弃体积克分子浓度“Ｍ”。换算：１Ｍ＝１ｍｏｌ／Ｌｍ＝１ｋｍｏｌ／ｍ３废弃当量浓度“Ｎ”。换算：１Ｎ＝（１ｍｏｌ／Ｌ）÷离子价数９．暂时可与ＳＩ（国际单位制）并用的非法定计量单位如埃（Ａ）和居（里）（Ｃｉ）请换算成；１Ａ...

关键词： muscle fiber type Flexor pollicis longus Extensor pollicis longus Myosin ATPase Human

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