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Physical exercise protects muscle from accelerated aging induced by high-salt intake and muscle CG2196(salt)gene overexpression in Drosophila

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Food Science and Human Wellness 2023年第6期12卷 1948-1960页

作者： Dengtai Wen Yiling Chen Xu Tian Wenqi Hou Department of Physical Education Ludong UniversityYantai 264025China College of Physical Education Yichun UniversityYichun 336000China School of Exercise and Health Shanghai University of SportShanghai 200438China

aging decreases muscle mass,strength,and functional ***-salt stress seems to promote muscle aging and decrease ***,exercise delays muscle aging and increases longevity,and it may protect muscle from rapid aging induced by high-salt intake(HSI),but the molecular mechanisms are poorly *** this study,the flies were fed a high-salt diet and trained to *** CG2196(salt)gene and dSir2 gene were over-expressed by building mef2-gal4/UAS *** results showed that both physical exercise and muscle dSir2 gene overexpression prevented HSI-induced and muscle salt overexpression-induced accelerated age-related decline of climbing index,climbing endurance,muscle NAD^(+)level,SOD activity level,dSir2 expression,and dFOXO expression,and they also prevented HSI-induced and muscle salt overexpression-induced accelerated age-related increase in muscle ROS level,MDA level,and salt gene *** exercise improved lifespan decrease induced by HSI and muscle salt ***,current results indicated that high-salt stress accelerated muscle aging by decreasing muscular NAD^(+)/dSir2/dFOXO pathway activity and increasing oxidative *** exercise protected muscle from accelerated aging induced by high-salt stress through activating muscle NAD^(+)/dSir2/dFOXO pathway and enhancing muscle oxidation *** combination of exercise and muscle dSir2 overexpression had the best protective effect on muscle aging and lifespan in flies.

关键词： Physical exercise high-salt intake muscle aging NAD^(+)/dSir2

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Presenilin and Alzheimer’s disease interactions with aging,exercise and high-fat diet:A systematic review

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BIOCELL 2023年第1期47卷 41-49页

作者： YINGHUI GAO DENGTAI WEN SHIJIE WANG JINGFENG WANG Ludong University Yantai264025China

Presenilin(Psn)protein is associated with organismal *** in the Psn gene may lead to Alzheimer’s disease(AD),dilated cardiomyopathy(DCM),and many age-dependent degenerative *** diseases seriously affect the quality of life and longevity of the population and place a huge burden on health care and economic systems around the *** have two types of Psn,presenilin-1(PSEN1)and presenilin-2(PSEN2).Mutations in the genes encoding PSEN1,PSEN2,and amyloid precursor protein(APP)have been identified as the major genetic causes of *** is a complex gene strongly influenced by genetic and environmental *** effects of exercise,training,and a high-fat diet on the Psn gene expressed in the heart and its related pathways are not fully ***,relevant aspects of the mutational effects on Psn can be studied experimentally in easily handled animal models,including Drosophila,mice,and other animals,all of which share orthologous genes of Psn with *** previous studies have linked aging,exercise training,and a high-fat diet to the Psn *** review discusses the interrelationship between aging,exercise training,and a high-fat diet on the Psn gene and its associated disease,*** aim is to understand the adverse effects of Psn gene mutations on the body and the diseases caused by AD,find ways to alleviate the adverse effects and provide new directions for the improvement of treatment strategies for diseases caused by Psn gene mutations.

关键词： Genetic mutations Drosophila Cardiac aging muscle aging Neurodegenerative disease

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