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First molecular cytogenetic characterisation of tracheal squamous cell carcinoma cell line kln 205

Journal of Cancer Metastasis and Treatment 2021年第1期7卷 524-531页

作者： Shaymaa Azawi Thomas Liehr Martina Rincic Institute of Human Genetics Jena University HospitalFriedrich Schiller UniversityJena 07747Germany Croatian Institute for Brain Research School of Medicine University of ZagrebZagreb 10000Croatia

Aim:murine tumour cell lines have been used in thousands of ***,it is rather the rule than exception for most of them that not much is known about their genetic *** squamous cell carcinoma(SCC)cell line kln 205 is such an *** 205 cells have not been studied yet for karyotype or acquired copy number variations(CNVs),but they have been used as models for(metastatic)lung cancer,lung-SCC,non-small cell lung cancer,tongue cancer and subcutaneous ***,it was characterised cytogenomically for the first ***:The cell line kln 205 was characterised comprehensively by molecular cytogenetics using multicolour banding as well as molecular *** on these results,a map of the imbalances and breakpoints determined in the murine genome was translated to the human ***:Here,it could be shown that this>40-year-old cell line has a stable,approximately tetraploid karyotype comprising 77-82 ***,there are few structural chromosomal aberrations:only six derivatives involving chromosomes 2,3,5,9,10 and/or 19 could be *** to the literature,SCCs derived from different human tissues,as well as lung SCC and non-small cell lung cancer,display overall similar CNV ***:Thus,according to the genetic profile found here,kln 205 can be applied as a general model for human SCC;it is also suited as a model for lung cancer in *** molecular genetic characterisation of kln 205 cell line may find more lung-and/or SCC-specific alterations.

关键词： Lung cancer squamous cell carcinoma(SCC) murine cell line kln 205 murine multicolour banding(mcb) array comparative genomic hybridisation(aCGH)

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