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Meiotic abnormalities in metaphase I human spermatocytes from infertile males： frequencies, chromosomes involved, and relationship with polymorphic karyotype and seminal parameters

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Asian Journal of Andrology 2014年第6期16卷 838-844页

作者： Zaida Sarrate Francesca Vidal Joan Blanco Unitat de Biologia Cel.lular Facultat de Biociencies Universitat Autonoma de Barcelona Bellaterra (Cerdanyola del Valles) 08193 Spain.

The aim of this study was to look in depth at the relationship between meiotic anomalies and male infertility, such as the determination of the chromosomes involved or the correlation with patient features. For this purpose, a total of 31 testicular tissue samples from individuals consulting for fertility problems were analyzed. Metaphase I cells were evaluated using a sequential methodology combining Leishman stained procedures and multiplex fluorescence in situ hybridization protocols. The number of chromosomal units and chiasmata count per bivalent were established and a hierarchical cluster analysis of the individuals was performed. The relationship of the seminogram and the karyotype over recombination were evaluated using Poisson regression models. Results obtained in this study show a significant percentage of infertile individuals with altered meiotic behavior, mostly specified as a reduction in chiasmata count in medium and large chromosomes, the presence of univalents, and the observation of tetraploid metaphases. Moreover, the number and the type of anomalies were found to be different between cells of the same individual, suggesting the coexistence of cell lines with normal meiotic behavior and cell lines with abnormalities. In addition, chromosomal abnormalities in metaphase I are significantly associated with oligozoospermia and/or polymorphic karyotype variants.

关键词： chiasmata count human spermatocytes multiplex fluorescence in situ hybridization polymorphic karyotype seminalparameters

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