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multiple organ dysfunction and rhabdomyolysis associated with moonwort poisoning: Report of four cases

World Journal of Clinical Cases 2020年第2期8卷 479-486页

作者： Fang Li An-Bao Chen Yong-Chun Duan Rui Liao Yu-Wei Xu Li-Li Tao Department of Emergency Medicine The Second Affiliated Hospital of Kunming Medical University

BACKGROUND Moonwort is a widely used Chinese herbal medicine. It has various pharmacological effects, such as relieving cough and preventing asthma. To date,multiple organ dysfunction and rhabdomyolysis caused by moonwort poisoning have not been *** SUMMARY Here we report four cases of moonwort poisoning that presented with multiple organ dysfunction and rhabdomyolysis accompanied by vomiting, fatigue, and muscle aches. One patient was an adult male, two were adult females, and one was a boy, with an age range of 7–64 years. The adults were treated with hemoperfusion and symptomatic therapies, while the child was treated with plasma exchange and symptomatic therapies. All four patients *** Blood purification combined with symptomatic treatment may be an effective method for managing multiple organ dysfunction and rhabdomyolysis caused by acute moonwort poisoning.

关键词： Moonwort poisoning multiple organ dysfunction Rhabdomyolysis Hemoperfusion Plasma exchange Case report

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Moxifloxacin-induced multiple organ dysfunction possibly related to mutations in several genes involved in drug metabolism pathways

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Chinese Medical Journal 2013年第7期126卷 1396-1398页

作者： XIAO Yong-jiu SU Long-xiang ZHANG Xin XIE Li-xin Department of Respiratory Medicine Hainan Branch of Chinese People's Liberation Army General Hospital Sanya Hainan 572013 China Department of Respiratory Medicine L anzhou General Hospital of Lanzhou Military Area Command of Chinese People's Liberation Army Lanzhou Gansu 730050 China Medical College of Nankai University Tianjin 300071 China Department of Respiratory Medicine Chinese People's Liberation Army General Hospital Beijing 100853 China

Quinolones have been used to treat various infectious diseases. The addition of fluorine atoms has allowedfor extensive modifications of structures, which has enhanced the spectrum of activities and oral bioavailability of quinolones and resulted in the creation of fluoroquinolones） Although the adverse effects associated with fluoroquinolone antibiotics have decreased considerably and these drugs are generally well tolerated, adverse effects do sometimes occur.

关键词： moxifloxacin multiple organ dysfunction mutations

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Mild hypothermia in improving multiple organ dysfunction after cardiac arrest

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World Journal of Emergency Medicine 2010年第3期1卷 196-200页

作者： LinYang Xu-ming Zhao Li-junLiu Department of Emergency and Critical Care Medicine the Second Affiliated Hospital of Soochow UniversitySuzhou215004China

BACKGROUND:Resuscitation after cardiac arrest (CA) with a whole-body ischemia-reperfusion injury causes brain injury and multiple organ dysfunction (MODS). This study aimed to determine whether mild systemic hypothermia could decrease multiple organ dysfunctions after resuscitation from cardiac arrest.;METHODS:The patients who had been resuscitated after cardiac arrest were reviewed. During the resuscitation they had been assigned to undergo therapeutic hypothermia (target temperature, 32°C to 34°C, measured in the rectum) over a period of 24 to 36 hours or to receive standard treatment with normothermia. Markers of different organ injury were evaluated for the first 72 hours after recovery of spontaneous circulation (ROSC).;RESULTS:At 72 hours after ROSC, 23 patients in the hypothermia group for whom data were available had favorable neurologic, myocardial, hepatic and pulmonic outcomes as compared with 26 patients in the normothermia group. The values of renal function were not significantly different between the two groups. However, blood coagulation function was badly injured in the hypothermia group.;CONCLUSIONS:In the patients who have been successfully resuscitated after cardiac arrest, therapeutic mild hypothermia can alleviate dysfunction after resuscitation from cardiac arrest.

关键词： Cardiac arrest Ischemia reperfusion injury Mild hypothermia multiple organ dysfunction

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Compared Serum Proteomics Study on multiple organ dysfunction Following Intestinal Ischemia Reperfusion Injury in Rabbit

Compared Serum Proteomics Study on Multiple Organ Dysfunctio...

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第八届海峡两岸心血管科学研讨会

作者： Hong-jie LI~1,Rui-li YAO~2,Xiu-li MEN~1,Xiao-yan KONG~1,Li-jun ZHAO~1 (1.Department of Pathophysiology of Hebei United University,Tangshan 063000,China 2.Tangshan Vocational Technical college,Tangshan 063000,China)

＜正＞Objective To explore the changes of serum proteomics in rabbit multiple organ dysfunction following intestinal ischemia reperfusion injury as well as its possible *** multiple organ dysfunction （MODS） model in rabbits was induced by intestinal mesenteric artery occlusion for 4 h followed by reperfusion for 4 h,the changes in their organ function were *** model was considered successful if two or more organ system functional impairment *** samples were obtained from rabbits before and after the model of gut originated *** in samples were separated by two - dimensional electrophoresis （2 - DE）,the 2 - DE gels were stained by sliver staining and analyzed by PDQuest software 8.0 to compare the protein expression difference between the two *** spots with different expression level were subjected to matrix assisted laser desorption/ionization - time of flight - time of flight - mass spectrometry （MALDI - TOF - TOF - MS） for *** protein database was searched to further characterize the differential *** differential expression of haptoglobin and paraoxonase in serum before and after gut originated MODS was verified by western blot and *** 19 differential protein spots were screened out in the 2 - DE maps,11 proteins were up - regulated and 8 proteins were down - regulated in gut originated MODS rabbits’ s serum.4 of the 19 differential protein spots were selected for MALDI - TOF - TOF - MS study,and 2 of the 4 differential protein spots were identified satisfactorily as paraoxonase and haptoglobin, which content were increased in rabbits’ s serum after gut originated *** Serum proteomics of rabbit changed remarkably before and after gut originated MODS,paraoxonase and haptoglobin may be associated with the compensation after gut originated MODS.

关键词： serum proteomics multiple organ dysfunction ischemia reperfusion injury

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Association of low non-invasive near-infrared spectroscopic measurements during initial trauma resuscitation with future development of multiple organ dysfunction

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World Journal of Emergency Medicine 2015年第2期6卷 105-110页

作者： Bret A.Nicks Kevin M.Campons William P.Bozeman Department of Emergency Medicine Wake Forest School of Medicine2nd Meads HallMedical Center Boulevard

BACKGROUND: Near-infrared spectroscopy(NIRS) non-invasively monitors muscle tissue oxygen saturation(St O2). It may provide a continuous noninvasive measurement to identify occult hypoperfusion, guide resuscitation, and predict the development of multiple organ dysfunction(MOD) after severe trauma. We evaluated the correlation between initial St O2 and the development of MOD in multi-trauma ***: Patients presenting to our urban, academic, Level I Trauma Center/Emergency Department and meeting standardized trauma-team activation criteria were enrolled in this prospective trial. NIRS monitoring was initiated immediately on arrival with collection of St O2 at the thenar eminence and continued up to 24 hours for those admitted to the Trauma Intensive Care Unit(TICU). Standardized resuscitation laboratory measures and clinical evaluation tools were collected. The primary outcome was the association between initial St O2 and the development of MOD within the f irst 24 hours based on a MOD score of 6 or greater. Descriptive statistical analyses were performed; numeric means, multivariate regression and rank sum comparisons were utilized. Clinicians were blinded from the StO 2 ***: Over a 14 month period, 78 patients were enrolled. Mean age was 40.9 years(SD 18.2), 84.4% were male, 76.9% had a blunt trauma mechanism and mean injury severity score(ISS) was 18.5(SD 12.9). Of the 78 patients, 26(33.3%) developed MOD within the first 24 hours. The MOD patients had mean initial St O2 values of 53.3(SD 10.3), signifi cantly lower than those of nonMOD patients 61.1(SD 10.0); P=0.002. The mean ISS among MOD patients was 29.9(SD 11.5), significantly higher than that of non-MODS patients, 12.1(SD 9.1)(P<0.0001). The mean shock index(SI) among MOD patients was 0.92(SD 0.28), also signifi cantly higher than that of non-MODS patients, 0.73(SD 0.19)(P=0.0007). Lactate values were not signifi cantly different between ***: Non-invasive, continuous St O

关键词： Near-infrared spectroscopy multiple organ dysfunction Injury severity score Shock index Lactate

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Traditional Chinese medicine in COVID-19

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Acta Pharmaceutica Sinica B 2021年第11期11卷 3337-3363页

作者： Ming Lyu Guanwei Fan Guangxu Xiao Taiyi Wang Dong Xu Jie Gao Shaoqin Ge Qingling Li Yuling Ma Han Zhang Jigang Wang Yuanlu Cui Junhua Zhang Yan Zhu Boli Zhang State Key Laboratory of Component-based Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Artemisinin Research Center Institute of Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijing 100700China National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300193China Oxford Chinese Medicine Research Centre University of OxfordOxford OX13PTUK College of Traditional Chinese Medicine Hebei UniversityBaoding 071002China Institute of Basic Medicine and Cancer the Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital)Chinese Academy of SciencesHangzhou 310022China

COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2(SARSCo V-2)has spread across the globe,posing an enormous threat to public health and *** Chinese medicine(TCM),in combination with Western medicine(WM),has made important and lasting contributions in the battle against *** this review,updated clinical effects and potential mechanisms of TCM,presented in newly recognized three distinct phases of the disease,are summarized and *** integrating the available clinical and preclinical evidence,the efficacies and underlying mechanisms of TCM on COVID-19,including the highly recommended three Chinese patent medicines and three Chinese medicine formulas,are described in a *** hope that this comprehensive review not only provides a reference for health care professionals and the public to recognize the significant contributions of TCM for COVID-19,but also serves as an evidence-based in-depth summary and analysis to facilitate understanding the true scientific value of TCM.

关键词： COVID-19 SARS-CoV-2 Traditional Chinese medicine Clinical evidence Potential mechanism Viral infection Cytokine storm multiple organ dysfunction

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