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Intervention of multiple pathways by multiple active components provides potent protection against cerebral ischemia injury

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Journal of Chinese Pharmaceutical Sciences 2014年第5期23卷 295-301页

作者：张精亮胡涛刘晓岩朱元军王银叶北京大学医学部药学院分子与细胞药理学系北京100191

To explore the effect of multiple pathway intervention in acute cerebral ischemia injury, we prepared a medicine formula （formula 2） consisting of ginsenosides, pueraria flavonoids, ophiopogonis and borneol as a tool medicine. The effects of formula 2 and its components on PC12 cell viability and potential pathway were investigated, and the influence of this formula on venous thrombosis and platelet aggregation was also assessed, then the effect of formula 2 on middle cerebral artery occlusion （MCAO） reperfusion was observed in rats. Formula 2 markedly enhanced the cell viability, which was stronger than that of each individual component. Formula 2 significantly inhibited the NO production in PC12 cells induced by H202, and this effect was also stronger than that of each individual component. Moreover, formula 2 enhanced the SOD activity, and the effect was stronger than that of ginsenosides. In addition, formula 2 reduced the MDA content, and this effect was stronger than that of ophiopogonins. In vivo, formula 2 showed potent inhibitory effects on platelet aggregation and venous thrombosis. Furthermore, formula 2 （single dose, s.c.） significantly reduced the infarct volume and neurobehavioral scores in MCAO reperfusion rats. Take together, our results suggests that formula 2 has powerful ability of inhibiting the ischemia/reperfusion injury, and this effect might be attributed to its simultaneous intervention in the cascade reaction of neuronal injury via multiple pathways contributed by multiple components during cerebral ischemia/reperfusion.

关键词： multiple pathways multiple components Cerebral ischemia/reperfusion injury Formula 2

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Decomposition of a gas mixture of four n-alkanes using a DBD reactor

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Plasma Science and Technology 2020年第11期22卷 74-80页

作者： Boqiong JIANG Xiaodan FEI Shuiliang YAO Qinmin WANG Xinlei YAO Kai XU Zhizong CHEN School of Environmental Science and Engineering Zhejiang Gongshang UniversityHangzhou 310018People's Republic of China School of Environmental and Safety Engineering Changzhou UniversityChangzhou 213164People's Republic of China

This study investigates the decomposition of a gas mixture of four n-alkanes(n-heptane,n-octane,n-nonane,and n-decane)using a dielectric barrier discharge *** show that the conversion of n-alkanes increased from 7.2%(C7H(16)),9.7%(C8H(18)),8.4%(C9H(20)),and 10.5%(C(10)H(22))to 23.8%(C7H(16)),25.0%(C8H(18)),27.9%(C9H(20)),and 32.1%(C(10)H(22))when the energy density increased from 84 J l^-1 to 324 J l^-*** conversion of n-alkanes when using the gas mixture is close to that found when using a single *** influences of reaction temperature and O2 concentration are also investigated,and the activation energies for the decomposition of each alkane are given.

关键词： multiple components n-alkane decomposition dielectric barrier discharge energy efficiency activation energy

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Synthesis of Multi-component Mass-exchange Networks

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Chinese Journal of Chemical Engineering 2013年第4期21卷 376-381页

作者：刘琳琳都健 Mahmoud M. EI-Halwagi Jose Maria Ponce-Ortega 姚平经 Chemical Engineering Department Dalian University of Technology Dalian 116024 China Chemical Engineering Department Texas A&M University College Station TX 77843 USA Adjunct Faculty at the Chemical and Materials Engineering Department King Abdulaziz University Jeddah Saudi Arabia Chemical Engineering Department Universidad Michoacana de San Nicolas de Hidalgo Morelia Mich 58060 Mexico

This paper presents a superstructure-based formulation for the synthesis of mass-exchange networks (MENs) considering multiple components. The superstructure is simplified by directly using the mass separation agents (MSA) from their sources, and therefore the automatic synthesis of the multi-component system involved in the MENs can be achieved without choosing a 'key-component' either for the whole process or the mass exchangers. A mathematical model is proposed to carry out the optimization process. The concentrations, flow rates, matches and unit operation displayed in the obtained network constitute the exact representation of the mass exchange process in terms of all species in the system. An example is used to illustrate and demonstrate the application of the proposed method.

关键词： multiple components mass exchange network superstructure optimization

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