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Comparative evaluation of immunogenicity and protective efficacy of clumping factors, fibronectin-binding protein A and their combination against Staphylococcus aureus

Comparative evaluation of immunogenicity and protective effi...

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动物生态养殖、疫病防控、食品安全与人类健康——中国畜牧兽医学会家畜传染病学分会第八届全国会员代表大会暨第十五次学术研讨会

作者： Liang Chen Limeng Zhang Jian Dai Jianxin Zhang Xuan Yang Daolong Liu Xijing Yang Chunyu Tong Liquan Yu Zhanbo Zhu Fanze Piao Yudong Cui College of Life Science and Technology Heilongjiang Bayi Agricultural University

Staphylococcus aureus cause serious infections in human and animal bodies. Development of a combination vaccine, containing several bacterial virulence factors, is a promising strategy against S. aureus infections. Clumping factor A (ClfA), clumping factor B (ClfB) and fibronectin-binding protein (FnBPA) are three important adhesins of S. aureus and potential antigens for a multi-component vaccine. To evaluate the protective immunity of ClfA, ClfB, FnBPA and their combination of two against S. aureus infections in a murine lethal challenge model, mice were immunized with the antigens alone or combinations of two antigens by intramuscular injection. Antigen-specific antibody responses, opsonic activity of serum antibody and cytokines induced by the antigens in mice were assessed. Furthermore, the mice were challenged with three S. aureus strains-Newman, Wood46 and HLJ23/1. The results of high levels of IgG, number of specific IL-4 and IFN-γ secreting cells and amount of interleukin-17A (IL-17A) produced by the splenic lymphocytes showed all antigens could elicit strong humoral and cellular responses in mice, but combined-antigens could not elicit stronger humoral and cellular responses than individual antigens. The mice immunized with FnBPA showed a higher survival rate than others after challenged with a lethal dose of S. aureus Newman, Wood 46 and HLJ 23/1 strain. Consistently, the survival rates of mice immunized with combined antigens were not increased. In summary, these data suggested that ClfA, ClfB and FnBPA could induce a mixed Th1-Th2 immune response in mice and IL-17-mediated immune response. The FnBPA antigen could provide a better immune protection in the murine lethal challenge model.

关键词： Mastitis S. aureus multiple component vaccine immunity protection

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