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Isolation of antileishmanial,antimalarial and antimicrobial metabolites from Jatropha multifida

Asian Pacific Journal of Tropical Biomedicine 2014年第5期4卷 374-378页

作者： Abiodun Falodun Vincent Imieje Osayewenre Erharuyi Ahomafor Joy Peter Langer Melissa Jacob shabanna Khan Mohammed Abaldry Mark Hamann Department of Pharmaceutical Chemistry Faculty of PharmacyUniversity of Benin Department of Pharmacognosy School of PharmacyUniversity of Mississippi Institute of Organic Chemistry University of Rostock National Center for Natural Products Research Institute of Pharmaceutical SciencesUniversity of Mississippi

Objective:To investigate the antileishinanial,antimicrobial and antimalarial activities of the pure metabolites from Jatropha multifida used in African ***:The methanolic stem bark extract of Jatropha multifida used in Nigerian folk medicine as remedy against bacterial infections was subjected to column chromatography and HPLC analyses lo obtain three known metabolites,microcyclic lathyrane dilerpenoids(1-3).Structures were confirmed by comparison of 1D and 2D spectral data with ***:The three compounds exhibited inhibition of antileishmanial,antimalarial and antimicrobial actions against the tested organisms with compouds 2 and 3 active against Cryptococcus neoformans at IC_(50)of 82 and 8.7 μg/ml,***:The research lends support to the ethnomedicinal use of the plant in combating microbial infections,leishmaniasis and malarial infections.

关键词： Jatropha multifida Stem bark Antimalarial Leishmaniasis Antimicrobial

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Effects of <i>Biebersteinia multifida</i>DC. Root Extract on Physical Stamina in Male Mice

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Food and Nutrition Sciences 2015年第3期6卷 326-331页

作者： Mahsa Hadipour Jahromy Ahmad Jamshidi Mohajer Leila Adibi Shahrzad Khakpour Herbal Pharmacology Research Centre Tehran Medical Sciences Branch Islamic Azad University Tehran Iran Biology Department Faculty of Biological Sciences Islamic Azad University North Tehran Branch Tehran Iran

Biebersteinia multifida DC. has been used for the purpose of development of physical strength in iranian folk medicine. In the present study, we investigated the effect of Biebersteinia multifida DC. root extract on performance of the Forced Swimming Test (FST), and on blood biochemical parameters related to fatigue: Blood Urea Nitrogen (BUN), Creatine Kinase (CK), Lactic Dehydrogenase (LDH), Glucose (Glc), and Total Protein (TP). Biebersteinia multifida DC. root extract was orally administered to mice at the doses 4, 7 and 10 mg/kg continuously once per day for 1 and 7 days using a feeding atraumatic needle. After 7 days, on FST the immobility time was decreased in the treated-groups at the doses 4 and 7 mg/kg, but after 1 day, only the immobility time of the treated- group at the dose of 4 mg/kg was decreased significantly. In addition, the content of Glc and TP in the blood serum was significantly increased in the groups receiving 4 and 7 mg/kg of Biebersteinia multifida DC. root extract for 7 days and LDH was decreased significantly. However, the levels of BUN and CK did not show a significant change. The results predict a potential benefit of Biebersteinia multifida DC. root extract as an anti-fatigue treatment and for improving physical stamina.

关键词： Biebersteinia multifida DC. Forced Swimming Test Physical Stamina

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