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Yin-Zhi-Huang granule improved the localization and expression of Oatp2,Ntcp,Mrp2 and Bsep on estrogeninduced cholestasis rats

Yin-Zhi-Huang granule improved the localization and expressi...

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2012年甘肃省“食品安全与健康生活”学术年会

作者： Zhou Xin-An Wu Department of Pharmacy the first hospital of Lanzhou University College of Pharmaceutical Science Lanzhou University the First Clinical Medical College of Lanzhou University

Ethnopharmacological relevance:Cholestasis is an impairment of nomal bile flow and bile acids secretion,which are related to many transporters in ***-Zhi-Huang granule(YZH),a decoction of Yin Chin(Artemisia capillaris) and three other herbs,has been widely used in China to prevent and treat neonatal jaundice and cholestasis, which has engendered great clinical *** aim of the study was to investigate the preventive or therapeutic mechanisms of YZH on estrogeninduced rat cholestasis based on the hepatic 0atp2, Ntcp,Mrp2 and Bsep. Materials and methods:Starting 5 successive days after received subcutaneous injections of estradiol benzoate(EB,5mg/kg/d) once daily,rats were oral administrated YZH(3g/kg/d) for 7,14 and 21 days. Results:Rats that underwent EB -treated had elevated serum TBA and DBIL levels,which were reduced to 61%and 73%by YZH in 14 days, ***,EB caused hepatic necrosis, inflammation,hyperplastic cholangioles,phlebectasis and congestion,all of which were largely improved by *** abnormal distribution of Oatp2,Ntcp, Mrp2 and Bsep followed by necrosis and loss nuclei cells were observed in EB-treated rats’ liver,which was slightly less severe in YZH-treated rats’ liver. EB-treated caused a significant decreased expression of Oatp2,Ntcp,Mrp2 and Bsep(Oatp2:38±3.3%;Ntcp:35±7.4%;Bsep:21±2.1%;Mrp2:113±2.3%;P2,Ntcp anoMrp2proteins mass was observed after *** no significant change was seen in Bsep expression. Conclusion:In conclusion,there are two major mechanisms of the preventive or therapeutic effect of YZH during estrogen -induced cholestasis:(1) improvement of the localization of Oatp2,Ntcp, Mrp2and Bsep;(2) increasing of the protein mass of Oatp2,Ntcp and Mrp2.

关键词： Yin-Zhi-Huang granule cholestasis Na +-taurocholate co -transporting polypeptide organic anion transporting polypeptides 2 bile salt export pump multidrug-resistance-associatedprotein 2

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