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Molecular bases of Sorcin-dependent resistance to chemotherapeutic agents

cancer Drug resistance 2018年第3期1卷 164-180页

作者： Ilaria Genovese Andrea Ilari Theo Battista Valerio Chiarini Francesco Fazi Annarita Fiorillo Gianni Colotti Department of Radiology Oncology and PathologySapienza University of RomeRome 00161Italy. IBPM-CNR Institute of Molecular Biology and PathologyItalian National Research CouncilRome 00185Italy. Department of Biochemical Sciences Sapienza University of RomeRome 00185Italy. Institute of Biotechnology University of HelsinkiHelsinki 00014Finland. Department of Anatomical HistologicalForensic Medicine&Orthopedic SciencesSapienza University of Romelaboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci BolognettiRome 00161Italy

Soluble resistance-related calcium binding protein(Sorcin)is a protein initially labelled“resistance-related”,since it is co-amplified with ABCB1 in multidrug(MD)-resistant *** for years Sorcin overproduction was believed to be a by-product of the co-amplification of its gene with the P-glycoprotein gene,many recent studies view Sorcin as an oncoprotein,playing an important role in MD resistance(MDR).Sorcin is one of the most highly expressed calciumbinding proteins,which is overexpressed in many human tumors and MD resistant cancers,and represents a novel MDR *** expression in tumors inversely correlates with patients’response to chemotherapies and overall *** is highly expressed in MDR cell lines over their parent *** overexpression by gene transfection increases drug resistance to a variety of chemotherapeutic drugs in many cancer *** the other hand,Sorcin silencing leads to reversal of drug resistance in many cell *** review describes:(1)the roles of Sorcin in the cell;(2)the studies showing Sorcin overexpression in tumors and cancer cells;(3)the studies showing the effects of Sorcin overexpression and silencing;(4)the molecular effects of Sorcin overexpression;and(5)the structural and genetic bases of Sorcin-dependent MDR.

关键词： Sorcin calcium cancer multidrug resistance in cancer doxorubicin endoplasmic reticulum heart brain ryanodine receptors ER stress

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