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The emerging tumor microbe microenvironment: From delineation to multidisciplinary approach-based interventions

Acta Pharmaceutica Sinica B 2024年第4期14卷 1560-1591页

作者： Yu Fu Jia Li Wenyun Cai Yulan Huang Xinlong Liu Zhongyi Ma Zhongjie Tang Xufei Bian Ji Zheng Jiayun Jiang Chong Li Medical Research Institute College of Pharmaceutical SciencesSouthwest UniversityChongqing 400715China Institute of Hepatobiliary Surgery Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Department of Urology Urologic Surgery CenterXinqiao HospitalThird Military Medical University(Army Medical University)Chongqing 400037China

Intratumoral microbiota has become research hotspots,and emerges as a non-negligent new component of tumor microenvironments(TME),due to its powerful infuence on tumor initiation,metas-tasis,immunosurveillance and prognosis despite in *** accumulations of microbes,and their related components and metabolites within tumor tissues,endow TME with additional pluralistic features which are distinct from the conventional ***,it's definitely necessary to comprehen-sively delineate the sophisticated landscapes of tumor microbe microenvironment,as well as their func-tions and related underlying ***,in this review,we focused on the fields of tumor microbe microenvironment,including the heterogeneity of intratumor microbiota in different types of tu-mors,the controversial roles of intratumoral microbiota,the basic features of tumor microbe microenvi-ronment(i.e.,pathogen-associated molecular patterns(PAMPs),typical microbial metabolites,autophagy,infammation,multi-faceted immunomodulation and chemoresistance),as well as the multi-disciplinary approach-based intervention of tumor microbiome for cancer therapy by applying wild-type or engineered live microbes,microbiota metabolites,antibiotics,synthetic biology and rationally de-signed *** hope our work will provide valuable insight to deeply understand the interplay of cancer-immune-microbial,and facilitate the development of microbes-based tumor-specific treatments.

关键词： Tumor microbe microenvironment Microbiota metabolites Immunomodulation Chemoresistance multidisciplinary approach Genetically engineered microbiota Autophagy Outer membrane vesicles

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Current management of liver diseases and the role of multidisciplinary approach

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World Journal of Hepatology 2022年第11期14卷 1920-1930页

作者： Nouhoum Bouare Department of Assurance Quality and Biosafety/Biosecurity National Institute of Public HealthBamako 1771Mali

Liver is an organ having extremely diversified functions,ranging from metabolic and synthetic to detoxification of harmful *** multifunctionality of the liver in principle requires the multidisciplinary and pluralistic interventions for its *** studies have investigated liver function,dysfunction and *** editorial work discusses new ideas,challenges and perspectives of current research regarding multidisciplinary and pluralistic management of liver *** one hand the discussions have carried out on the involvement of extracellular vesicles,Na^(+)/H^(+) exchangers,severe acute respiratory syndrome coronavirus 2 and Epstein–Barr virus infections,Drug-induced liver injury,sepsis,pregnancy,and food supplements in hepatic *** the other hand this study has discussed hepatocellular carcinoma algorithms and new bio-chemical and imaging experiments pertaining to liver *** articles with an impact index value">0"from reference citation analysis,which is an open multidisciplinary citation analysis database based on artificial intelligence technology,have served for the study’s *** work may be a useful tool for the clinical practice and research in managing and investigating liver disorders.

关键词： Liver management Liver function Liver dysfunction Liver clinic Liver diagnosis multidisciplinary approach

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A multidisciplinary,integrated approach for the elimination of schistosomiasis:a longitudinal study in a historically hyperendemic region in the lower reaches of the Yangtze River,China from 2005 to 2014

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Infectious Diseases of Poverty 2017年第1期6卷 484-494页

作者： Le-Ping Sun Wei Wang Yin-Ping Zuo Qing-Biao Hong Guang-Lin Du Yu-Cai Ma Jian Wang Guo-Jing Yang Dao-Jian Zhu You-Sheng Liang Key Laboratory of National Health and Family Planning Commission on Parasitic Disease Control and Prevention No.117 YangxiangMeiyuanWuxi CityJiangsu Province 214064China Jiangsu Provincial Key Laboratory on Parasites and Vector Control Technology No.117 YangxiangMeiyuanWuxi CityJiangsu Province 214064China Jiangsu Institute of Parasitic Diseases No.117 YangxiangMeiyuanWuxi CityJiangsu Province 214064China Yangzhou Municipal Center for Disease Control and Prevention No.36 Yanfu East RoadYangzhou CityJiangsu Province 225000China Hanjiang District Center for Disease Control and Prevention Wenhui West RoadYangzhou CityJiangsu Province 225000China

Background:Although great success has been achieved,schistosomiasis remains a major public health concern in China,and the remaining core endemic regions are concentrated along the middle and lower reaches of the Yangtze *** this longitudinal study,we evaluated the effectiveness of a multidisciplinary,integrated approach for schistosomiasis elimination in a historically hyper-endemic region in the lower reaches of the Yangtze River,China over the 10-year period from 2005 through ***:A three-step roadmap for schistosomiasis elimination was designed in the study site,and multidisciplinary,integrated interventions were implemented by the health,agriculture,water resources development,land and resources,and forestry sectors from 2005 to 2014,including chemotherapy for infected individuals,health education,management of the source of Schistosoma japonicum infection,and intermediate host snail *** annual number of schistosomiasis patients,*** infection in humans,bovines and Oncomelania hupensis snails,and water infectivity were observed to assess the effectiveness of the multidisciplinary,integrated approach for the elimination of ***:There was a tendency towards a gradual decline in both the number of schistosomiasis cases and the prevalence of *** human infection across the study period from 2005 through *** *** human infection was detected since 2012,and no acute infection was seen since *** the study period,no infection was found in bovines,and a 0.03%overall infection rate was observed in *** *** 2009,no infected snails were identified,and the area of both snail habitats and infected snail habitats appeared a reduction over the study *** the 3-year multidisciplinary,integrated control,infection control was achieved,and transmission control was achieved after 6-year implementation,with all infected snails and water infectivity eliminated;in addition,the 10-year i

关键词： Schistosomiasis Elimination multidisciplinary approach Integrated control Yangtze River Longitudinal study China

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Application of multidisciplinary in situ simulation training in the treatment of acute ischemic stroke: a quality improvement project

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World Journal of Emergency Medicine 2024年第1期15卷 41-46页

作者： Ganying Huang Huijie Yang Huan Yao Xinxin Fan Wenqin Xia Yuansheng Xu Xiaoling Shen Xue Zhao Fourth School of Clinical Medicine Zhejiang Chinese Medical UniversityHangzhou 310053China Emergency Medicine Departent Hangzhou First People's HospitalHangzhou 310006China

BACKGROUND:Ischemic stroke refers to a disorder in the blood supply to a local area of brain tissue for various reasons and is characterized by high morbidity,mortality,and *** reperfusion of brain tissue at risk of injury is crucial for the treatment of acute ischemic *** purpose of this study was to evaluate comfort levels in managing acute stroke patients with hypoxemia who required endotracheal intubation after multidisciplinary in situ simulation training and to shorten the door-to-image ***:This quality improvement project utilized a comprehensive multidisciplinary in situ simulation exercise.A total of 53 participants completed the two-day in situ simulation *** main outcome was the self-reported comfort levels of participants in managing acute stroke patients with hypoxemia requiring endotracheal intubation before and after simulation training.A 5-point Likert scale was used to measure participant comfort.A paired-sample t-test was used to compare the mean self-reported comfort scores of participants,as well as the endotracheal intubation time and door-to-image time on the fi rst and second days of in situ simulation *** door-to-image time before and after the training was also ***:The findings indicated that in situ simulation training could enhance participant comfort when managing acute stroke patients with hypoxemia who required endotracheal intubation and shorten door-to-image *** the emergency management of hypoxemia or tracheal intubation,the mean post-training self-reported comfort score was signifi cantly higher than the mean pre-training comfort score(hypoxemia:4.53±0.64 vs.3.62±0.69,t=-11.046,P<0.001;tracheal intubation:3.98±0.72 vs.3.43±0.72,t=-6.940,P<0.001).We also observed a decrease in the tracheal intubation and door-to-image time and a decreasing trend in the door-to-image time,which continued after the ***:Our study demonstrates that the implementation of in s

关键词： Ischemic stroke Endotracheal intubation Door-to-image time In situ simulation multidisciplinary approach

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Airway management of a patient with linear immunoglobulin A bullous dermatosis:A case report

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World Journal of Clinical Cases 2024年第13期12卷 2263-2268页

作者： Olga C Nin Robert Hutnik Neil N Chheda David Hutchinson Department of Anesthesiology University of Florida College of MedicineGainesvilleFL 32610United States Department of Otolaryngology University of Florida College of MedicineGainesvilleFL 32610United States

BACKGROUND There is limited literature on managing the airway of patients with linear immunoglobulin A(IgA)bullous dermatosis,a rare mucocutaneous disorder that leads to the development of friable *** clinical decision making is necessary when there is a risk of bleeding into the airway,and a multidisciplinary team approach may lead to decreased patient morbidity during these high-risk scenarios,especially when confronted with an unusual cause for *** SUMMARY A 45-year-old African American female presented to our ambulatory surgical center for right corneal transplantation due to corneal perforation after blunt trauma in the setting of cicatricial conjunctivitis and diffuse corneal neovascularization from linear IgA bullous *** diagnosis of IgA dermatosis was recent,and the patient had been lost to *** severity of the disease and extent of airway involvement was unknown at the time of the *** airway bleeding was noticed upon intubation and the otorhinolaryngology team had to be called to the operating *** patient required transfer to the intensive care unit where a multidisciplinary team was involved in her *** patient was extubated on postoperative day *** A multidisciplinary approach to treating this disease is the best course of action before a surgical *** our case,key communication between the surgery,anesthesia,and dermatology teams led to the quick and safe treatment of our patient’s *** surgery should not be considered for these cases unless they are in full remission and there is no mucous membrane involvement.

关键词： Airway management Bleeding risk Linear immunoglobulin A bullous dermatosis multidisciplinary approach Outpatient procedure Case report

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Study on the Safety and Prevention Technology of Coal Mining under the River in Xingyuan Coal Mine

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Open Journal of Geology 2024年第3期14卷 339-402页

作者： Abdoulaye Sylla Wenbing Guo School of Energy Science and Engineering Henan Polytechnic University Jiaozuo China

Coal mining-induced surface subsidence poses significant ecological and infrastructural challenges, necessitating a comprehensive study to ensure safe mining practices, particularly in underwater conditions. This project aims to address the extensive impact of coal mining on the environment, infrastructure, and overall safety, focusing on the Shigong River area above the working face. The study employs qualitative and quantitative analyses, along with on-site engineering measurements, to gather data on crucial parameters such as coal seam characteristics, roof rock lithology, thickness, water resistance, and structural damage degree. The research encompasses a multidisciplinary approach, involving mining, geology, hydrogeology, geophysical exploration, rock mechanics, mine surveying, and computational mathematics. The importance of effective safety measures and prevention techniques is emphasized, laying the foundation for research focused on the Xingyun coal mine. The brief concludes by highlighting the potential economic and social benefits of this project and its contribution to valuable experience for future subsea coal mining.

关键词： Coal Mining-Induced Surface Subsidence Ecological and Infrastructural Challenges Safe Mining Practices Underwater Conditions multidisciplinary approach Safety Measures Prevention Techniques

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Challenges and advancing strategies of endoscopic submucosal dissection for early gastric cancer:The puzzle of eCura C1

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World Journal of Gastrointestinal Endoscopy 2024年第8期16卷 439-444页

作者： Giulio Calabrese Guido Manfredi Marcello F Maida Francesco V Mandarino Endrit Shahini Francesco Pugliese Paolo Cecinato Liboria Laterza Emanuele Sinagra Sandro Sferrazza Department of Gastroenterology and Endoscopy ARNAS Civico–Di Cristina–BenfratelliPalermo 90127SiciliaItaly Department of Gastroenterology and Digestive Endoscopy Ospedale MaggioreCrema 26013Italy Department of Medicine and Surgery University of Enna"Kore"Enna 94100SiciliaItaly Department of Gastroenterology and Digestive Endoscopy IRCCS Ospedale San RaffaeleMilan 20132LombardyItaly Department of Gastroenterology National Institute of Gastroenterology-IRCCS“Saverio de Bellis”Castellana GrotteBari 70013Italy Department of Digestive and Interventional Endoscopy Niguarda HospitalASST NiguardaMilan 20162LombardyItaly Department of Medical and Surgical Sciences IRCCS Azienda Ospedaliero-Universitaria di BolognaPoliclinico Sant’OrsolaBologna 40138Emilia-RomagnaItaly Department of Gastroenterology and Endoscopy Fondazione Instituto San Raffaele GiglioCefalù90015PalermoItaly

In this editorial,we explore the challenges of managing noncurative resections in early gastric cancer after endoscopic submucosal dissection(ESD),starting from the consideration recently made by Zhu et ***,we evaluate the management of eCura C1 lesions,where decisions regarding further interventions are pivotal yet *** among endoscopists,surgeons,and pathologists is underscored to refine risk assessment and personalize therapeutic *** advancements in ESD techniques and interdisciplinary collaboration offer opportunities for outcome optimization in managing eCura C1 ***,despite needing further clinical validation,molecular biomarkers have emerged as promising tools for enhancing *** manuscript highlights the ongoing research attempts to define treatment paradigms effectively and evaluates the potential of emerging options,ultimately aiming to improve patient care and outcomes in this complex clinical scenario.

关键词： Early gastric cancer Endoscopic submucosal dissection eCura Non-curative resection multidisciplinary approach

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Large,unresectable malignant fibrous histiocytoma:PET/CT-guided treatment with a multidisciplinary,minimally invasive approach

Large,unresectable malignant fibrous histiocytoma:PET/CT-gui...

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中国(第七届)肿瘤微创治疗学术大会暨世界影像导引下肿瘤微创治疗学会成立筹备大会

作者： Chuanxing Li,Dong Chen,Ketong Wu,Sheng Peng,Fujun Zhang Department of Medical Imaging & Interventional Radiology,Cancer Center and State Key Laboratory of Oncology in South China,Sun Yat-sen University,Guangzhou,510060,P.R.China.

Purpose To evaluate the effectiveness and safety of a PET/CT-guided,multidisciplinary,minimally invasive approach to the treatment of patients with large,unresectable,malignant fibrous *** approach includes microwave ablation and absolute alcohol therapy combined with 125I seed *** and Methods Seven patients(5 males and 2 females,42-48 years-old,mean 49.7 years-old) with large,unresectable malignant fibrous histiocytoma participated in this *** tumors had an average maximum diameter of 14.1 cm(10.0-19.0 cm) and were treated using a PET/CT-guided,multidisciplinary,minimally invasive *** patients received a PET/CT scan 2 months after the ***-up was conducted for an average of 35.7(2-45) months to determine the local control rate,overall survival rate,and clinical *** Follow-up times ranged from 2 to 45 *** was significantly relieved in patients treated with multidisciplinary,minimally invasive *** on PET/CT, complete response was achieved in 5 patients(71.4%),partial response in the other 2 patients(28.6%).The response rate of this multidisciplinary,minimally invasive treatment was 100%.The median survival time was 35.7 *** patients were alive 2 years after the *** patients were still alive after 3 *** patient died from cachexia and infection in the 3rd year,and another died of lung dysfunction from pulmonary metastases in the 2nd *** 3-year survival rate was 71.4%.The long-term complications included hyperpigmentation at the operative sites(n = 5) and insensible feeling at the ablation sites(n=3).Conclusion:PET/CT-guided multidisciplinary,minimally invasive approach is an effective,safe,and feasible means of treating large,unresectable malignant fibrous histiocytoma with minimal damage and few complications,but large-scale randomized clinical trials are necessary to confirm this assessment.

关键词： Malignant fibrous histiocytoma multidisciplinary approach PET-CT microwave ablation absolute alcohol 125I brachytherapy

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Rare combination of traumatic subarachnoid-pleural fistula and intracranial subdural hygromas:A case report

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World Journal of Clinical Cases 2023年第21期11卷 5173-5178页

作者： Po-Han Chen Chi-Ruei Li Cheat-Wei Gan Tsung-Hsi Yang Cheng-Siu Chang Fook-How Chan Department of Neurosurgery School of MedicineChung Shan Medical University HospitalTaichung 40201TaiwanChina Department of Neurosurgery Neurological InstituteTaichung Veterans General HospitalTaichung 40201TaiwanChina

BACKGROUND Subarachnoid-pleural fistula(SPF)is a complex and rare condition characterized by a pathological shunt between the subarachnoid and pleural *** can lead to the accumulation of cerebrospinal fluid(CSF)in the pleural space,pneumocephalus,and the development of central nervous system *** or thoracic spinal surgery are common causes of SPF,with symptoms including postural headache,consciousness status changes,and *** combination of SPF and subdural hygroma is a severe and rare condition,with little existing literature on its clinical *** SUMMARY We report a case of an 83-year-old male patient with traumatic SPF and bilateral frontal subdural hygroma following a fall from *** patient initially presented with severe lower back and buttock *** admission,the patient developed worsening lower limb weakness and pleural *** investigation revealed the presence of subdural hygromas with mass effect,requiring emergency bilateral subdural drainage.A multidisciplinary approach was undertaken to manage this complex condition,including intervention for hypovolemic CSF status and subdural hygroma *** pleural effusion eventually resolved and the patient attained a higher level of con-sciousness after bilateral hygroma drainage *** also reviewed the present literature relating to this rare combination of medical *** Traumatic SPF with subsequent subdural hygroma is a rare but serious *** the optimal treatment strategy for this complex condition remains uncertain,our literature review suggested that a multidisciplinary approach,including intervention for hypovolemic CSF and management of the subdural hygroma,is the most beneficial.

关键词： Subarachnoid-pleural fistula Subdural hygroma Trauma Hypovolemic cerebrospinal fluid multidisciplinary approach Case report

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Combined and sequential treatment of oral and maxillofacial malignancies： an evolving concept and clinical protocol

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Chinese Medical Journal 2008年第19期121卷 1945-1952页

作者： ZHENG Jia-wei QIU Wei-liu ZHANG Zhi-yuan Department of Oral and Maxillofacial Surgery College of Stomatology Shanghai Ninth People's Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200011 China

Objective To introduce the concept and rational regimens and present the latest development of combined treatment of oral and maxillofacial malignancies. Data sources The related published literature was searched through the CNKI database and MEDLINE using the terms of oral cancer, oral and maxillofacial malignancies, combined and sequential therapy, multidisciplinary approach. Study selection The available related literature was read and evaluated. Studies that met the inclusion criteria were selected. Results The results show that oral and maxillofacial malignancies diagnosed at an early stages （stages Ⅰ and Ⅱ） can be well treated with surgery alone and/or radiotherapy with optimal outcome, but advanced or recurrent diseases should be treated with rational combined and sequential treatment modalities. The use of concomitant chemoradiotherapy, taxane-containing, three-drug induction regimens and Cetuximab in combination with chemotherapy or radiotherapy demonstrated favorable results in previously untreated patients with head and neck squamous cell carcinoma. Conclusions The concept of combined and sequential treatment of advanced oral and maxillofacial malignancies should be widely accepted, and the rational regimen for individual and each type of entity should be determined based on the anatomical site and the patient＇s performance status.

关键词： oral cancer oral and maxillofacial malignancies combined and sequential therapy multidisciplinary approach

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