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Development and Validation of an Automatic Ultrawide-Field Fundus Imaging Enhancement System for Facilitating Clinical Diagnosis:A Cross-Sectional multicenter study

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Engineering 2024年第10期41卷 179-188页

作者： Qiaoling Wei Zhuoyao Gu Weimin Tan Hongyu Kong Hao Fu Qin Jiang Wenjuan Zhuang Shaochi Zhang Lixia Feng Yong Liu Suyan Li Bing Qin Peirong Lu Jiangyue Zhao Zhigang Li Songtao Yuan Hong Yan Shujie Zhang Xiangjia Zhu Jiaxu Hong Chen Zhao Bo Yan Department of Ophthalmology Eye&ENT Hospital of Fudan UniversityShanghai 200231China School of Computer Science Shanghai Key Laboratory of Intelligent Information ProcessingFudan UniversityShanghai 200433China The Affiliated Eye Hospital of Nanjing Medical University Nanjing 210029China Ningxia Eye Hospital People’s Hospital of Ningxia Hui Autonomous RegionThird Clinical Medical College of Ningxia Medical UniversityYinchuan 750002China Department of Ophthalmology The First Affiliated Hospital of Anhui Medical UniversityHefei 230022China Southwest Hospital/Southwest Eye Hospital Third Military Medical University(Army Medical University)Chongqing 400038China Key Lab of Visual Damage and Regeneration Restoration of Chongqing Chongqing 400038China Department of Ophthalmology The Affiliated Xuzhou Municipal Hospital of Xuzhou Medical UniversityXuzhou 221000China Department of Ophthalmology Suqian First Hospital of Jiangsu Province HospitalSuqian 223800China Department of Ophthalmology The First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Ophthalmology The Fourth Affiliated Hospital of China Medical UniversityEye Hospital of China Medical UniversityShenyang 110000China Department of Ophthalmology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Ophthalmology Jiangsu Province HospitalNanjing 210029China Shaanxi Eye Hospital Xi’an People’s Hospital(Xi’an Fourth Hospital)The Affiliated People’s Hospital of Northwest UniversityXi’an 710004China

In ophthalmology,the quality of fundus images is critical for accurate diagnosis,both in clinical practice and in artificial intelligence(AI)-assisted *** the broad view provided by ultrawide-field(UWF)imaging,pseudocolor images may conceal critical lesions necessary for precise *** address this,we introduce UWF-Net,a sophisticated image enhancement algorithm that takes disease characteristics into *** the Fudan University ultra-wide-field image(FDUWI)dataset,which includes 11294 Optos pseudocolor and 2415 Zeiss true-color UWF images,each of which is rigorously annotated,UWF-Net combines global style modeling with feature-level lesion *** consistency loss is also applied to maintain fundus feature integrity,significantly improving image *** and qualitative evaluations demonstrated that UWF-Net outperforms existing methods such as contrast limited adaptive histogram equalization(CLAHE)and structure and illumination constrained generative adversarial network(StillGAN),delivering superior retinal image quality,higher quality scores,and preserved feature details after *** disease classification tasks,images enhanced by UWF-Net showed notable improvements when processed with existing classification systems over those enhanced by StillGAN,demonstrating a 4.62%increase in sensitivity(SEN)and a 3.97%increase in accuracy(ACC).In a multicenter clinical setting,UWF-Net-enhanced images were preferred by ophthalmologic technicians and doctors,and yielded a significant reduction in diagnostic time((13.17±8.40)s for UWF-Net enhanced images vs(19.54±12.40)s for original images)and an increase in diagnostic accuracy(87.71%for UWF-Net enhanced images vs 80.40%for original images).Our research verifies that UWF-Net markedly improves the quality of UWF imaging,facilitating better clinical outcomes and more reliable AI-assisted disease *** clinical integration of UWF-Net holds great

关键词： Ultrawide-field imaging Fundus photography Image enhancement algorithm Artificial intelligence multicenter study Artificial intelligence-assisted diagnostics Diagnostic accuracy

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Current treatment paradigm and survival outcomes among patients with newly diagnosed multiple myeloma in China:a retrospective multicenter study

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Cancer Biology & Medicine 2023年第1期20卷 77-87页

作者： Huishou Fan Weida Wang Ya Zhang Jianxiang Wang Tao Cheng Lugui Qiu Xin Wang Zhongjun Xia Gang An State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood DiseasesHaihe Laboratory of Cell EcosystemInstitute of Hematology&Blood Diseases HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300020China State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer CenterGuangzhou 510060China Department of Hematology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021China

Objective:Evidence on the prognostic value of autologous stem cell transplantation(ASCT)and minimal residual disease(MRD)dynamics of patients with newly diagnosed multiple myeloma(NDMM)in China is *** objective in the current study was to understand the current care paradigm and outcomes of these ***:This longitudinal cohort study used historical data from three top-tier hematologic disease care hospitals that contributed to the National Longitudinal Cohort of Hematological Diseases-Multiple *** regimens[proteasome inhibitor(PI)-,immunomodulatory drug(IMiD)-,PI+IMiD-based,and conventional],post-induction response,ASCT and MRD status,and survival outcomes[progression-free survival(PFS)and overall survival(OS)]were ***:In total,454 patients with NDMM were included(median age,57 years;59.0%males)with a median follow-up of 58.7 *** overall response rate was 91.0%,83.9%,90.6%,and 60.9%for PI-,IMiD-,PI+IMiD-based,and conventional regimens,*** with ASCT during first-line therapy(26.2%)had a longer PFS and OS than patients who did not receive ASCT[median PFS,42.9 vs.21.2 months,Pstudy showed that novel agent-based regimens,first-line ASCT,and sustained MRD negativity were associated with a superior outcome for patients with NDMM in China(Identifier:NCT04645199).

关键词： Multiple myeloma autologous stem cell transplantation minimal residual disease survival outcomes multicenter study

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A multicenter study of Viral Aetiology of Community-Acquired Pneumonia in Hospitalized Children in Chinese Mainland

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Virologica Sinica 2021年第6期36卷 1543-1553页

作者： Yun Zhu Baoping Xu Changchong Li Zhimin Chen Ling Cao Zhou Fu Yunxiao Shang Aihuan Chen Li Deng Yixiao Bao Yun Sun Limin Ning Shuilian Yu Fang Gu Chunyan Liu Ju Yin Adong Shen Zhengde Xie Kunling Shen Laboratory of Infection and Virology Beijing Pediatric Research InstituteBeijing Key Laboratory of Pediatric Respiratory Infection DiseasesResearch Unit of Critical Infection in ChildrenChinese Academy of Medical Sciences2019RU016Beijing Children's HospitalCapital Medical UniversityKey Laboratory of Major Diseases in ChildrenMinistry of EducationNational Clinical Research Center for Respiratory DiseasesNational Center for Children's HealthBeijing 100045China Department of Respiratory Diseases I Beijing Children's HospitalCapital Medical UniversityNational Clinical Research Center for Respiratory DiseasesNational Center for Children's HealthBeijing 100045China The 2nd Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou 325027China The Children's Hospital of Zhejiang University School of Medicine Hangzhou 310005China Children's Hospital Capital Institute of Pediatrics Beijing 100020China Children's Hospital of Chongqing Medical University Chongqing 400015China Shengjing Hospital of China Medical University Shenyang 110004China The First Affiliated Hospital of Guangzhou Medical University Guangzhou 510120China Guangzhou Women and Children's Medical Center Guangzhou 510623China Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200092China Yinchuan Women and Children Healthcare Hospital Yinchuan 750000China Children's Hospital of Changchun Changchun 130000China The 2nd Affiliated Hospital of Harbin Medical University Harbin 150086China Baoding Children's Hospital Baoding 071051China Laboratory of Respiratory Diseases Beijing Key Laboratory of Pediatric Respiratory Infection DiseasesBeijing Pediatric Research InstituteBeijing Children's HospitalCapital Medical UniversityKey Laboratory of Major Diseases in ChildrenMinistry of EducationNational Clinical Research Center for Respiratory DiseasesNational Center for Children's HealthBeijing 100045China Beijing Children's Hospital Capital Medical UniversityNationa

Community-acquired pneumonia(CAP) is one of the leading causes of morbidity and mortality in children *** this study,we aimed to describe the aetiology of viral infection of pediatric CAP in Chinese *** November2014 to June 2016,the prospective study was conducted in 13 *** hospitalized children under 18 years old who met the criteria for CAP were *** throat swabs or nasopharyngeal aspirates(NPAs) were collected which were then screened 18 respiratory viruses using multiplex PCR *** pathogens were present in 56.6%(1539/2721) of the enrolled cases,with the detection rate of single virus in 39.8% of the cases and multiple viruses in 16.8% of the *** most frequently detected virus was respiratory syncytial virus(RSV)(15.2%,414/2721).The highest detection rate of virus was in <6-month-age group(70.7%,292/413).RSV,human metapneumovirus(HMPV),human parainfluenza viruses(HPIVs) and influenza B virus(Flu B) showed the similar prevalence patterns both in north and south China,but HPIVs,Flu A,human bocavirus(HBoV),human adenovirus(HAdV) and human coronaviruses(HCoVs) showed the distinct circulating patterns in north and south *** enterovirus/human rhinovirus(HEV/HRV)(27.6%,27/98),HBoV(18.4%,18/98),RSV(16.3%,16/98) and HMPV(14.3%,14/98) were the most commonly detected viruses in severe pneumonia cases with single virus *** conclusion,viral pathogens are frequently detected in pediatric CAP cases and may therefore play a vital role in the aetiology of *** was the most important virus in hospitalized children with CAP in Chinese mainland.

关键词： Children Community-acquired pneumonia multicenter study Viral aetiology Multiplex PCR assay

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Male reproductive function before and after the adjustment of the COVID-19 prevention policy:a multicenter study in China

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Asian Journal of Andrology 2024年第3期26卷 308-314页

作者： Jian-Zheng Li Han Wu Li Wang Yun-Shan Wang Feng Kong Long-Qiao Cao Ming Liang Xiong Wang Ming-Zhen Yuan Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan 250000China Institute of Women Children and Reproductive HealthShandong UniversityJinan 250012China Engineering Laboratory of Urinary Organ and Functional Reconstruction of Shandong Province Jinan 250000China The First People’sHospital of Jining Jining 272000China Department of Reproductive Medicine The Second Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan 250000China Reproductive Medicine Center Affiliated Yantai Yuhuangding Hospital of Qingdao UniversityYantai 264000China

At the end of 2022,the adjustment of the coronavirus disease 2019(COVID-19)pandemic control policy in China resulted in alarge-scale increase in public *** compare the fertility parameters of male patients before and after the adjustments ofthe COVID-19 pandemic control policy in China,we collected data on patients’medical histories and laboratory examinations ontheir first visits between June 2022 and March 2023 in five different *** were divided into five groups according tothe timeline of the policy *** data we collected from male patients included semen quality and serum reproductivehormone levels,and intergroup comparisons were made using the Mann–Whitney U and Chi-square *** total,16784 casesunderwent regular semen analysis,11180 had sperm morphology assessments,and 7200 had reproductive hormone *** showed declining trends in semen volume,sperm motility,and the progressive sperm motility rate after the policy *** comparison revealed an initial decrease and gradual recovery in progressive motility *** morphology analysisshowed increased neck and tail abnormalities after the policy *** significant change in hormone levels was *** the adjustment of the COVID-19 prevention policy in China,a decline in sperm motility and morphology was *** trend may gradually recover over 2 *** the policy adjustment,reproductive hormone levels were relatively stablethroughout,except for an increase in luteinizing hormone(LH).These changes in semen parameters suggest that the policyadjustment had a short-to medium-term impact on male reproductive function.

关键词： COVID-19 multicenter study reproduction SARS-CoV-2 semen analysis

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Rapid screening for Klinefelter syndrome with a simple high-resolution melting assay： a multicenter study

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Asian Journal of Andrology 2018年第4期20卷 349-354页

作者： Dong-Mei Fu Yu-Lin Zhou Jing Zhao Ping HU Zheng-Feng Xu3 Shi-Ming Lv Jun-Jie HU Zhong-Min Xia Qi-Wei Guo United Diagnostic and Research Center for Clinical Genetics School of Public Health of Xiamen University and Xiamen Maternal and Child Health Hospital Xiamen 361003 China Xiamen Kingnova Biological Technology Co. Ltd. Xiamen 361028 China Center of Medical Genetics Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University Nanjing 210029 China Clinical Analysis Center Women's Hospital School of Medicine Zhejiang University Hangzhou 310006 China

Klinefelter syndrome （KS） is the set of symptoms that result from the presence of an extra X chromosome in males. Postnatal population-based KS screening will enable timely diagnosis of this common chromosomal disease, providing the opportunity for early intervention and therapy at the time point when they are most effective and may prevent later symptoms or complications. Therefore, through this study, we introduced a simple high-resolution melting （HRM） assay for KS screening and evaluated its clinical sensitivity and specificity in three medical centers using 1373 clinical blood samples. The HRM assay utilized a single primer pair to simultaneously amplify specific regions in zinc finger protein, X-linked （ZFX） and zinc finger protein, Y-linked （ZFY）. In cases of KS, the ratios of ZFX/ZFYare altered compared to those in normal males. As a result, the specific melting profiles differ and can be differentiated during data analysis. This HRM assay displayed high analytical specificity over a wide range of template DNA amounts （5 ng-50 ng） and reproducibility, high resolution for detecting KS mosaicism, and high clinical sensitivity （100%） and specificity （98.1%）. Moreover, the HRM assay was rapid （2 h per run）, inexpensive （0.2 USD per sample）, easy to perform and automatic, and compatible with both whole blood samples and dried blood spots. Therefore, this HRM assay is an ideal postnatal population-based KS screening tool that can be used for different age groups.

关键词： high-resolution melting Klinefelter syndrome multicenter study postnatal population-based screening

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Clinical characteristics and survival of 5283 esophageal cancer patients: A multicenter study from eighteen hospitals across six regions in China

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Cancer Communications 2020年第10期40卷 531-544页

作者： Yutong He Di Liang Lingbin Du Tiantian Guo Yanyu Liu Xibin Sun Ning Wang Min Zhang Kuangrong Wei Baoen Shan Wanqing Chen Cancer Institute the Fourth Hospital of Hebei Medical University/the Tumor Hospital of Hebei ProvinceShijiazhuangHebei 050000P.R.China Zhejiang Cancer Center HangzhouZhejiang 310000P.R.China Henan Cancer Hospital ZhengzhouHenan 450000P.R.China Beijing Cancer Hospital Beijing 100021P.R.China Hubei Cancer Hospital WuhanHubei 430000P.R.China Zhongshan Cancer Hospital ZhongshanGuangdong 528400P.R.China National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Science&Peking Union Medical CollegeBeijing 100021P.R.China

Objective:This study aimed to investigate the potential determining epidemiological and clinical risk factors affecting the survival of esophageal cancer(EC)patients across multiple hospitals in ***:This was a multicenter study comprising of newly diagnosed EC cases from Beijing,Hebei,Henan,Hubei,Zhejiang,and Guangdong Province of *** baseline characteristics and treatment methods data were collected from their medical *** EpiData software was used for data quality *** Kaplan-Meier method was used to estimate their overall survival(OS),and the Cox’s proportional hazard regression model was used to estimate hazard ratios(HR)and 95%confidence interval(CI).Results:The 3-and 5-year OS rates of the 5283 investigated EC patients were 49.98%and 39.07%,*** median survival was 36.00 *** median survival time of females was longer than that of males(females ***:45.00 vs.33.00,Pstudy reveals imp

关键词： esophageal cancer overall survival epidemiology lifestyle clinical factors risk factors multicenter study

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A multicenter study of the clinicopathological characteristics and a risk prediction model of early-stage breast cancer with hormone receptor-positive/human epidermal growth factor receptor 2-low expression

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Chinese Medical Journal 2023年第24期136卷 2967-2973页

作者： Ling Xin Qian Wu Chongming Zhan Hongyan Qin Hongyu Xiang Min Gao Xuening Duan Yinhua Liu Jingming Ye Chinese Society of Breast Surgery(CSBrS) Chinese Society of Surgery of Chinese Medical Association Department of Breast and Thyroid Peking University First HospitalBeijing 100034China Jun Yi Tai He Medical Technology Co.Ltd. Beijing 100024China 不详

Background:In light of the significant clinical benefits of antibody-drug conjugates in clinical trials,the human epidermal growth factor receptor 2(HER2)-low category in breast cancers has gained increasing ***,we studied the clinicopathological characteristics of Chinese patients with hormone receptor(HR)-positive/HER2-low early-stage breast cancer and developed a recurrence risk prediction ***:Female patients with HR-positive/HER2-low early-stage breast cancer treated in 29 hospitals of the Chinese Society of Breast Surgery(CSBrS)from Jan 2015 to Dec 2016 were *** clinicopathological data and prognostic information were collected,and machine learning methods were used to analyze the prognostic ***:In total,25,096 patients were diagnosed with breast cancer in 29 hospitals of CSBrS from Jan 2015 to Dec 2016,and clinicopathological data for 6486 patients with HER2-low early-stage breast cancer were *** them,5629 patients(86.79%)were *** median follow-up time was 57 months(4,76 months);the 5-year disease-free survival(DFS)rate was 92.7%,and the 5-year overall survival(OS)rate was 97.7%.In total,412 cases(7.31%)of metastasis were observed,and 124(2.20%)patients *** Cox regression analysis revealed that T stage,N stage,lymphovascular thrombosis,Ki-67 index,and prognostic stage were associated with recurrence and metastasis(P<0.05).A recurrence risk prediction model was established using the random forest method and exhibited a sensitivity of 81.1%,specificity of 71.7%,positive predictive value of 74.1%,and negative predictive value of 79.2%.Conclusion:Most of patients with HER2-low early-stage breast cancer were HR-positive,and patients had favorable outcome;tumor N stage,lymphovascular thrombosis,Ki-67 index,and tumor prognostic stage were prognostic *** HR-positive/HER2-low early-stage breast cancer recurrence prediction model established based on the random forest method h

关键词： Breast cancer Hormone positive HER2-low expression multicenter study

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Geriatric Assessment to Predict Survival and Risk of Serious Adverse Events in Elderly Newly Diagnosed Multiple Myeloma Patients： A multicenter study in China

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Chinese Medical Journal 2017年第2期130卷 130-134页

作者： Yu-Ping Zhong Yi-Zhuo Zhang Ai-Jun Liao Su-Xia Li Chen Tian Jin Lu Department of Hematology Beijing Chaoyang Hospital (West) Capital Medical University Beijing University Clinical Research Institute Beijing 100043 China Department of Hematology Tianjin Medical University Cancer Institute and Hospital Tianjin Cancer Hospital Tianjin 300000 China Department of Hematology Shengjing Hospital of China Medical University Shenyang Liaoning 110004 China Department of Hematology The People's Liberation Army 301 Hospital Beijing 100853 China Department of Hematology The People's Liberation Army 304 Hospital Beijing 100048 China Department of Hematology Peking University People's Hospital and Peking University Institute of Hematology Beijing 100044 China

Background： Elderly multiple myeloma （MM） patients often tend to suffer a variety of diseases, so the treatment of choice is very difficult for the elderly myeloma patients. The overall survival （OS） time and side effects with elderly patients are unclear in China. The study tried to find out the role of geriatric assessment in the Chinese elderly MM. Methods： We retrospectively analyzed the data of 628 newly diagnosed patients from six hospitals from June 2011 to June 2013. A geriatric assessment had been performed to assess comorbidities, cognitive, and physical status for these patients. The primary endpoint was to evaluate different physical states of elderly patients with OS time and treatment-related side effects. Results： An additive scoring system （range： 0-5）, based on age, Katz＇s Activity of Daily Living （ADL） and Lawton＇s Instrumental Activity of Daily Living （IADL）〈5 and Charlson Comorbidity Index （CC1） was developed to identify three groups： fit （score = 0）; intermediate-fitness （score = 1 ）; and fi＇ail （score ≥2）. The 3-year OS was 63% in fit patients, 63% in intermediate-fimess patients, and 49% in frail patients ≥3 hematologic adverse events （AEs） were documented in 45 （35.4%） fit, 34 （34%） intermediate-fitness, and 121 （30.2%） frail patients. The risk of a grade ≥3 hematologic AEs was not significantly increase in intermediate-fitness （hazard ratios [HR]： 0.99, 95% confidence interval [CI]： 0.54 1.47, P = 1.000） and in frail patients （tfR： 1.16, 95% CI： 0.70-1.93, P- 0.558） compared with fit ones. Conclusions： MM occurs earlier in life and being advanced when the diagnosis is made in the mainland of China. The overall survival in fi＇ailty with International Staging System （ISS） ll/lll was the worst in all patients.

关键词： Geriatric Assessment multicenter study Multiple Myeloma

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Screening of Class 1 and Class 2 Integrons in Clinical Isolates of Pseudomonas aeruginosa Collected from Seven Hospitals in Turkey:A multicenter study

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Open Journal of Medical Microbiology 2013年第4期3卷 227-233页

作者： Aysegul Copur Cicek Aysegul Saral Azer Ozad Duzgun Zeynep Cizmeci Tuba Kayman Pervin Ozlem Balci Tuba Dal Mehmet Firat Yelda Yazici Metin Sancaktar Osman Birol Ozgumus Cemal Sandalli Department of Medical Microbiology Faculty of MedicineRecep Tayyip Erdogan UniversityRizeTurkey Department of Biology Faculty of Arts and SciencesArtvin Coruh UniversityArtvinTurkey Department of Genetics and Bioengineering Faculty of Engineering and Natural SciencesGumushane UniversityGumushaneTurkey Clinical Microbiology Laboratory Kecioren Research and Training HospitalAnkaraTurkey Clinical Microbiology Laboratory Research and Training HospitalKayseriTurkey Clinical Microbiology Laboratory General State HospitalTokatTurkey Department of Medical Microbiology Faculty of MedicineDicle UniversityDiyarbakirTurkey Clinic of Infectious Diseases and Clinical Microbiology Private OSM Ortadogu HospitalSanliurfaTurkey Clinical Microbiology Laboratory Ahi Evren Chest and Cardiovascular Surgery Research and Training HospitalTrabzonTurkey Clinical Microbiology Laboratory Akcaabat Hackali Baba General State HospitalTrabzonTurkey Department of Biology Faculty of Arts and SciencesRecep Tayyip Erdogan UniversityRizeTurkey

Pseudomonas aeruginosa is one of the leading nosocomial pathogens worldwide, and their infections are difficult to treat due to acquired resistance to many antibiotics. This study aimed to detect class 1 and 2 integrons and antibiotic susceptibility of clinical isolates of P. aeruginosa. Two hundred and five P. aeruginosa strains were collected from the seven general state hospitals in Turkey. They were characterized by antimicrobial susceptibility testing, screened for class 1 and class 2 integrons, and evaluated for the association between antibiotic resistance phenotypes and the presence of integrons. intI gene was amplified in 10 isolates (4.87%) by PCR and in seven isolates of them (70%) were found different gene cassettes. The aadA gene integrated into the class 1 integrons was most frequently found and it was followed by aac genes and blaOXA family genes. Sequence analysis of variable regions of the class 1 integrons showed five gene cassette arrays;aadA1(99%), aac(3)-Id(82%)-orf-aac(3”)-Ia(99%), aac(3)-Ie(83%)-blaoxa10(100%)- aadA1 (100%), aadA6(99%, 100%), aac(6’)-I(97%)-orf-aadA2(99%). No class 2 integron was detected. This study is the first multicenter study for class 1 integrons and it indicates the low rate of presence of class 1 gene cassette in P. aeruginosa.

关键词： Pseudomonas aeruginosa Antibiotic Resistance Class 1 Integron AadA multicenter study

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Hybrid argon plasma coagulation for the treatment of Barrett’s esophagus:A prospective,multicenter study

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World Journal of Clinical Cases 2024年第19期12卷 3866-3872页

作者： Dong Wang Yan Chen Feng Ji Jian-Wei Hu Ping-Hong Zhou Shu-Chang Xu Ying Chen Li-Ping Ye Guo-Liang Ye Rui Li Zhao-Shen Li Department of Gastroenterology Shanghai Ninth People's Hospital Affiliated to Shanghai Jiaotong University School of MedicineShanghai 200011China Department of Gastroenterology Changhai HospitalShanghai 200438China Department of Gastroenterology The First Affiliated Hospital Zhejiang University School of MedicineHangzhou 311399Zhejiang ProvinceChina Endoscopy Center Zhongshan HospitalFudan UniversityShanghai 200032China Endoscopy Center Tongji Hospital of Tongji UniversityShanghai 200092China Department of Gastroenterology Taizhou Hospital of Zhejiang ProvinceTaizhou 318001Zhejiang ProvinceChina Department of Gastroenterology The Affiliated Hospital of Medicine SchoolNingbo UniversityNingbo 315021Zhejiang ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina

BACKGROUND The incidence of Barrett’s esophagus(BE)in China is lower compared to the Western ***,studies conducted in the Chinese population has been *** current treatment options available for BE treatment includes argon plasma coagulation(APC),radiofrequency ablation and cryoablation,all with varying degrees of *** To determine the efficacy and safety of HybridAPC in the treatment of *** The study cohort consisted of patients with BE who underwent HybridAPC ablation *** procedures were performed by seven endoscopists from different tertiary *** duration of the procedure,curative rate,complications and recurrent rate by 1-year follow-up were *** Eighty individuals were enrolled for treatment from July 2017 to June 2020,comprising of 39 males and 41 females with a median age of 54 years(range,30 to 83 years).The technical success rate of HybridAPC was 100%and the overall curative rate was 98.15%.No severe complications occurred during the *** cases were classified as short-segment BE and long-segment *** with short-segment BE were all considered cured without ***-six patients completed the one-year follow-up without ***-four percent had mild dysplasia which were all resolved with one post-procedural *** mean duration of the procedure was 10.94±6.52 *** Treatment of BE with HybridAPC was found to be a simple and quick procedure that is safe and effective during the short-term follow-up,especially in cases of short-segment *** technique could be considered as a feasible alternative ablation therapy for BE.

关键词： Barrett’s esophagus Hybrid argon plasma coagulation Ablation treatment Prospective study multicenter study

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