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Simulating traumatic brain injury in vitro:developing high throughput models to test biomaterial based therapies

Neural Regeneration Research 2023年第2期18卷 289-292页

作者： Raja Haseeb Basit Jessica Wiseman Farhana Chowdhury Divya Maitreyi Chari Bradford Royal infirmary BradfordWest YorkshireUK Sheffield Institute for Translational Neuroscience University of SheffieldSheffieldUK Labcorp Drug Development HarrogateUK Neural Tissue Engineering Keele Group School of MedicineKeele UniversityStaffordshireUK

Traumatic brain injuries are serious clinical incidents associated with some of the poorest outcomes in neurological *** with the limited regenerative capacity of the brain,this has significant implications for patients,carers,and healthcare systems,and the requirement for life-long care in some *** treatment currently focuses on limiting the initial neural damage with longterm care/support from multidisciplinary *** targeting neuroprotection and neural regeneration are not currently available but are the focus of intensive ***-based interventions are gaining popularity for a range of applications including biomolecule and drug delive ry,and to function as cellular *** investigations into the development of such novel therapeutics for traumatic brain injury will be critically underpinned by the availability of appropriate high thro ughput,facile,ethically viable,and pathomimetic biological model *** represents a significant challenge for researchers given the pathological complexity of traumatic brain ***,there is a concerted post-injury response mounted by multiple neural cell types which includes microglial activation and astroglial scarring with the expression of a range of growth inhibito ry molecules and cytokines in the lesion ***,we review common models used for the study of traumatic brain injury(ranging from live animal models to in vitro systems),focusing on penetrating traumatic brain injury *** discuss their relative advantages and drawbacks for the developmental testing of biomaterial-based therapies.

关键词： astroglial scar biomaterial cortical culture in vitro model microglial infiltration multicellular model penetrating injury scaffold traumatic brain injury

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