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Investigating design principles of micropatterned encapsulation systems containing high-density microtissue arrays

Science China(Life Sciences) 2014年第2期57卷 221-231页

作者： JIANG LiYang LIU JiaYing WANG Kai GU Xi LUO Ying Department of Biomedical Engineering College of Engineering Peking University National Engineering Laboratory for Regenerative and Implantable Medical Devices

Immunoisolation is an important strategy to protect transplanted cells from rejection by the host immune ***,microfabrication techniques have been used to create hydrogel membranes to encapsulate microtissue in an arrayed *** method illustrates a new macroencapsulation paradigm that may allow transplantation of a large number of cells with microscale spatial control,while maintaining an encapsulation device that is easily maneuverable and remaining integrated following *** study aims to investigate the design principles that relate to the translational application of micropatterned encapsulation membranes,namely,the control over the transplantation density/quantity of arrayed microtissues and the fidelity of pre-formed microtissues to *** hydrogel membranes with microwell patterns were used as a model encapsulation system to exemplify these *** results show that high-density micropatterns can be generated in hydrogel membranes,which can potentially maximize the percentage volume of cellular content and thereby the transplantation efficiency of the encapsulation *** seeding of microtissues demonstrates that microwell structures can efficiently position and organize pre-formed microtissues,suggesting the capability of micropatterned devices for manipulation of cellular transplants at multicellular or tissue *** theoretical analysis was performed to provide insights into the relationship between micropatterns and the transplantation capacity of membrane-based *** study lays the ground for developing new macroencapsulation systems with microscale cellular/tissue patterns for regenerative transplantation.

关键词： hydrogel micropattern array multi-cellular spheroids macroencapsulation

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