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Novel Primate Bocaparvovirus Species 3 Identified in Wild Macaca mulatta in China

Virologica Sinica 2020年第1期35卷 34-42页

作者： Yuanyun Ao Zhaojun Duan Chinese Center for Disease Control and Prevention National Institute for Viral Disease Control and PreventionBeijingChina

Primate bocaparvovirus(BOV) is a possible cause of respiratory disorders and gastroenteritis in humans. However, the diversity and evolution of these viruses remain largely unknown, despite the identification of a growing number of BOVs in non-human primates(NHPs). Here, we report the identification of a novel BOV(provisionally named Macaca mulatta bocaparvovirus [MmBOV]) in the feces of wild Macaca mulatta in China by viral metagenomic analysis. Seven of 400 fecal samples from Macaca mulatta were positive for MmBOV. An almost complete genome sequence of 4,831 nucleotides was obtained, which had genomic organization and protein motifs similar to human bocaviruses(HOBVs), and shared characteristically low G/C content and weak codon usage bias. Sequence analyses of NS1, NP1, and VP1 revealed that Mm BOV was most closely related to HBOV4 of Primate bocaparvovirus 2(approximately 68.4%/70.6%, 73.3%/67.6%, and 70.4%/73.1% nucleotide/amino acid identities, respectively). Additionally, phylogenetic analysis revealed that Mm BOV formed an independent peripheral branch, but clustered closely with those of the Primate bocaparvovirus species in the BOV genus(particularly HBOV4). These data strongly suggest that HBOV4 originated from NHP bocaparvoviruses around 200–300 years ago, and that NHPs may act as HBOV reservoirs. Following the International Committee of Taxonomy for Viruses guidelines, we propose Mm BOV as a new species(tentatively named Primate bocaparvovirus 3) in the genus Bocaparvovirus, which is the first report of a novel species of primate BOV. Our data facilitate future research on the genetic diversity and evolution of primate bocaparvoviruses and highlight the importance of bocaparvovirus surveys in wild NHPs.

关键词： Primate bocaparvovirus(BOV) Novel species Macaca mulatta Sequence analysis Phylogenetic analysis

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Expression of gelatinases and tissue inhibitors of metallo-proteinases in the rhesus monkey(Macaca mulatta) corpus luteum

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Chinese Science Bulletin 2001年第15期46卷 1292-1296页

作者： LI Qinglei, WANG Hongmei, SHAO Longjiang, YU Xiaoguang, Nl Jiang & ZHU Cheng1. State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China 2. Laboratory of Reproductive Endocrinology, Harbin Medical University, Harbin 150001, China State Key Laboratory of Reproductive Biology Institute of Zoology Chinese Academy of Sciences Beijing China Laboratory of Reproductive Endocrinology Harbin Medical University Harbin China

Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are believed to play important roles in the formation and regression of corpus luteum (CL). This study is to investigate the expression of gelatinases (MMP-2, -9) and TIMPs in the rhesus monkey CL in both early and late luteal phases and during the early stages of pregnancy. Ovaries were collected from regularly cycling rhesus monkey at D5 and D15 following ovulation and at D12, D18 and D26 of pregnancy. In situ hybridization revealed that in the CL MMP-2 niRNA was expressed during both formation and regression, while MMP-9 mRNA was mainly localized in the late luteal phase. Reduction of MMP-2, -9 transcripts in the CL was observed during pregnancy. MMP-2 mRNA in the CL reduced to an undetectable level at D26 of pregnancy. TIMP-1 mRNA was highly expressed in the CL in both early and late luteal phases and persisted throughout the early stages of pregnancy. Strong signal for TIMP-2 mRNA was also detected in both luteal phases, and the

关键词： matrix metalloproteinases tissue inhibitors of metallo-proteinases gelatinases macaca mulatta corpus luteum.

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Effect of different anesthetic mixtures——ketamine-xylazine, ketamine-acepromazine and tiletamine-zolazepam——on the physiological and blood biochemistry parameters of male rhesus monkeys(Macaca mulatta) at different ages

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Animal Models and Experimental Medicine 2019年第2期2卷 83-97页

作者： Braulio Hernández‐Godínez Herlinda Bonilla Jaime Adrián Poblano Marcela Arteaga‐Silva Ameyalli Medina Hernández Armando Contreras‐Uribe Alejandra Ibanez-Contreras Posgrado en Ciencias Biológicas y de la Salud Unidad Iztapalapa Universidad Autónoma Metropolitana Ciudad de México México Investigación Biomédica Aplicada (INBIOMA) S.A.S. de C.V. Ciudad de México México Alimentos y Camas Zoosanitarias (ACAZOO) S. de R.L. Ciudad de México México Departamento Biología de la Reproducción Unidad Iztapalapa Universidad Autónoma Metropolitana Ciudad de México México Laboratorio de Neurofisiología Cognoscitiva Instituto Nacional de Rehabilitación Ciudad de México México

Background: Anesthetic agents are commonly utilized in the handling of non‐human primates for prevent the stress caused in physical exploration or physical restrain. For this reason, the objective of this work was to describe the effect of age and dissociative anesthetics (ketamine and tiletamine), and their combinations with acepromazine, xylazine and zolazepam, on the physiological and blood biochemical parameters in Macaca mulatta. Methods: Eighty male Macaca mulatta were divided into four experimental groups depending on the anesthetic mixture applied. Each group of 20 males was divided into five sub‐groups according to age. Physiological parameters were recorded every five minutes during a 30‐minute period. A blood sample was drawn to analyze blood biochemistry. Results: Statistical analyses revealed significant differences in the physiological parameters between the ketamine‐acepromazine and ketamine‐xylazine groups compared to the control group. The analysis of blood biochemistry found significant differences by age and by anesthetic mixture among all groups. Conclusion: These findings contribute to standardizing this animal model in biological research.

关键词： acepromazine anesthesia blood biochemistry ketamine Macaca mulatta physiologic parameters tiletamine xylazine zolazepam

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上海地区猕猴(Macaca mulatta)肠道弯曲菌(Campylobacter)感染情况的调查

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中国比较医学杂志 1993年第Z1期12卷 83-85页

作者：方林许翔钱开明中国科学院上海实验动物中心

弯曲菌病是一种人畜共患病,其中空肠弯曲菌和结肠弯曲菌是引起人类(尤其儿童)急性肠炎的重要病原之一,仅次于志贺氏菌,近年来日益为国内外医学界重视。猕猴作为实验动物,其弯曲菌感染率的高低将对公共卫生起重要作用。为此,作者按《Ber... 详细信息

弯曲菌病是一种人畜共患病,其中空肠弯曲菌和结肠弯曲菌是引起人类(尤其儿童)急性肠炎的重要病原之一,仅次于志贺氏菌,近年来日益为国内外医学界重视。猕猴作为实验动物,其弯曲菌感染率的高低将对公共卫生起重要作用。为此,作者按《Bergey系统细菌学手册》(1984)分类法,对上海地区281只不同年龄、性别猕猴肠道弯曲菌进行分离鉴定。现将结果报如下。

关键词： Campylobacter Macaca mulatta 弯曲菌病急性肠炎空肠弯曲菌结肠弯曲菌国内外医学界人畜共患病公共卫生系统细菌学

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Superior intestinal integrity and limited microbial translocation are associated with lower immune activation in SIVmac239-infected northern pig-tailed macaques(Macaca leonina)

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Zoological Research 2019年第6期40卷 522-531页

作者： Ming-Xu Zhang Tian-Zhang Song Hong-Yi Zheng Xue-Hui Wang Ying Lu Han-Dan Zhang Ting Li Wei Pang Yong-Tang Zheng Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province National Kunming High Level Biosafety Research Center for Non-human PrimatesKIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesKunming Institute of ZoologyChinese Academy of SciencesKunming Yunnan 650223China Kunming College of Life Science University of Chinese Academy of SciencesKunming Yunnan 650204China School of Life Sciences University of Science and Technology of ChinaHefei Anhui 230026China KIZ-SU Joint Laboratory of Animal Models and Drug Development College of Pharmaceutical SciencesSoochow UniversitySuzhou Jiangsu 215123China

Microbial translocation is a cause of systemic immune activation in HIV/SIV infection. In the present study, we found a lower CD8+ T cell activation level in Macaca leonina (northern pig-tailed macaques, NPMs) than in Macaca mulatta (Chinese rhesus macaques, ChRMs) during SIVmac239 infection. Furthermore, the levels of plasma LPS-binding protein and soluble CD14 in NPMs were lower than those in ChRMs. Compared with ChRMs, SIV-infected NPMs had lower Chiu scores, representing relatively normal intestinal mucosa. In addition, no obvious damage to the ileum or colon epithelial barrier was observed in either infected or uninfected NPMs, which differed to that found in ChRMs. Furthermore, no significant microbial translocation (Escherichia coli) was detected in the colon or ileum of infected or uninfected NPMs, which again differed to that observed in ChRMs. In conclusion, NPMs retained superior intestinal integrity and limited microbial translocation during SIV infection, which may contribute to their lower immune activation compared with ChRMs.

关键词： Immune activation Intestinal integrity Microbial translocation SIVmac239 Macaca leonina Northern pig-tailed macaques Macaca mulatta Chinese rhesus macaques

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Role of histo-blood group antigens in primate enteric calicivirus infections

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World Journal of Virology 2014年第3期3卷 18-21页

作者： Karol Sestak Division of Microbiology Tulane National Primate Research CenterTulane University School of Medicine

Human noroviruses(No V) are associated with large proportion of non-bacterial diarrhea outbreaks together with > 50% of food-associated diarrheas. The function of histo-blood group antigens(HBGAs) in pathogenesis of virus infection was implicated. Until recently however, due to lack of a robust animal and in vitro models of human NoV infection, only the partial knowledge concerning the virus pathogenesis(receptor, coreceptor and target cell) and absence of viable vaccine candidates were the frequently referenced attributes of this acute diarrheal illness. Recently, a novel group of enteric caliciviruses(CV) of rhesus macaque host origin was discovered and described. The new genus within the family Caliciviridae was identified: Rhesus Enteric CV, i.e., "Recovirus"(Re CV). Re CVs are genetically and biologically close relatives of human NoV s, exhibit similar genetic and biological features and are capable of being propagated in cell culture. ReC Vs cause symptomatic disease(diarrhea and fever) in experimentally inoculated macaques. Formulation and evaluation of efficient NoV vaccine might take several years. As suggested by recent studies, inhibition of HBGAs or HBGAbased antivirals could meanwhile be exploited as vaccine alternatives. The purpose of this minireview is to provide the guidance in respect to newly available primate model of enteric CV infection and its similarities with human NoV in utilizing the HBGAs as potential virus co-receptors to indirectly address the unresolved questions of NoV pathogenesis and immunity.

关键词： Calicivirus Norovirus Recovirus Rhesus macaque Macaca mulatta Enteric infection

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猕猴群内个体间的协作和竞争(英文)

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中山大学学报论丛 1995年第3期15卷 51-55页

作者：冯敏王骏华南濒危动物研究所广州510260

对华南地区四个野生猕猴群（深圳内伶仃岛、海南南湾半岛、广西龙虎山和湖南索溪裕）群内个体间的协作和竞争性行为的研究表明：婴猴由于其行为个体发育的不成熟，行为形式单调；成雄、成雌和未成年组协作和竞争活动是均衡的，但协作和... 详细信息

对华南地区四个野生猕猴群（深圳内伶仃岛、海南南湾半岛、广西龙虎山和湖南索溪裕）群内个体间的协作和竞争性行为的研究表明：婴猴由于其行为个体发育的不成熟，行为形式单调；成雄、成雌和未成年组协作和竞争活动是均衡的，但协作和竞争方式却不同．借助主成份分析发现在协作和竞争性行为分布上，挑衅性（威吓、攻击）行为对各年龄、性别组间差异的贡献量最大，结盟行为最少；竞争活动中：成雄挑衅行为最频繁，成雌较多，未成年组较少．协作活动中：成雄的结盟较少，成雌和未成年组结盟活动较多且比例相近．尽管猕猴群内个体间协作和竞争活动大都为食物、休息或活动地等，但协作和竞争方式对个体在群内的等级序位的获得和维持，进而获得个体利益有重要的作用．对各年龄、性别组的协作和竞争性行为分布的聚类分析表明：随年龄的增长，猕猴个体协作和竞争方式的性差异越为明显．

关键词： Macaca mulatta cooperation competition behavioral strategy

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