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F-18 fluorodeoxyglucose positron emission tomography/computed tomography image of gastric mucormycosis mimicking advanced gastric cancer: A case report

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World Journal of Clinical Cases 2019年第10期7卷 1155-1160页

作者： Bong-Il Song Department of Nuclear Medicine Dongsan Medical CenterKeimyung University School of Medicine

BACKGROUND mucormycosis is a very rare fungal infection,and its prognosis is *** common sites of infection are the sinuses,lung,or skin,and gastric involvement is *** standard antifungal therapy is the treatment of choice for gastric ***,the symptoms of gastric mucormycosis are varied and the early diagnosis is not *** SUMMARY I report a 53-year-old alcoholic man,who was admitted due to epigastric *** upper gastrointestinal endoscopy revealed a huge ulcer lesion in the stomach,which was suspected to be gastric cancer.F-18 fluorodeoxyglucose positron emission tomography/computed tomography(F-18 FDG PET/CT)showed diffusely intense FDG uptake at the ulcer lesion of the stomach,and several enlarged hypermetabolic lymph nodes were noted at the left gastric ***,endoscopy and F-18 FDG PET/CT findings suggested advanced gastric cancer with regional lymph node metastases,there was no cancer cells in the biopsy results and multiple fungal hyphae were noted in the periodic acid-Schiff stained *** He was diagnosed with gastric mucormycosis and successfully underwent amphotericin B and posaconazole treatment.

关键词： F-18 fluorodeoxyglucose Positron emission tomography mucormycosis Amphotericin B Gastric cancer Case report

Hepatic mucormycosis mimicking hilar cholangiocarcinoma:A case report and literature review

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World Journal of Gastroenterology 2010年第8期16卷 1039-1042页

作者： Li, Ke-Wei Wen, Tian-Fu Li, Gan-Di Sichuan Univ W China Hosp Div Liver Transplantat Chengdu 610041 Sichuan Prov Peoples R China Sichuan Univ W China Hosp Dept Pathol Chengdu 610041 Sichuan Prov Peoples R China

mucormycosis is a rare but invasive opportunistic fungal infection associated with a high mortality rate,and normally occurs in immunocompromised patients. In this report,we describe an immunocompetent patient suffering from hepatic mucormycosis secondary to adrenal mucormycosis,which masquerades as hilar cholangiocarcinoma. After surgical procedure and treatment with amphotericin B and itraconazole,the patient recovered well and had a 2-year infection-free survival. To our knowledge,this special clinical manifestation of hepatic infection as well as adrenal mucormycosis has not been reported to date. Mean-while,this is the first case of an immunocompetent patient with both adrenal and hepatic mucormycosis who has been treated successfully.

关键词： Adrenal gland Hilar cholangiocarcinoma Liver mucormycosis

COVID-19-associated mucormycosis and treatments

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Asian Pacific Journal of Tropical Medicine 2021年第9期14卷 401-409页

作者： Vetriselvan Subramaniyan Shivkanya Fuloria Hari Kumar Darnal Dhanalekshmi Unnikrishnan Meenakshi Mahendran Sekar Rusli Bin Nordin Srikumar Chakravarthi Kathiresan V.Sathasivam Shah Alam Khan Yuan Seng Wu Usha Kumari Kalvatala Sudhakar Rishabha Malviya Vipin Kumar Sharma Neeraj Kumar Fuloria Faculty of Medicine Bioscience and NursingMAHSA UniversityJalan SP 2Bandar Saujana Putra42610 Jenjarom SelangorMalaysia Faculty of Pharmacy&Centre of Excellence for Biomaterials Engineering AIMST UniversityBedong 08100KedahMalaysia Jeffrey Cheah School of Medicine&Health Sciences Monash UniversitySelangor 47500Malaysia College of Pharmacy National University of Science and Technology130 MuscatSultanate of Oman Department of Pharmaceutical Chemistry Faculty of Pharmacy and Health SciencesUniversiti Kuala Lumpur Royal College of Medicine PerakIpoh 30450Malaysia Faculty of Applied Science&Centre of Excellence for Biomaterials Engineering AIMST UniversityKedahBedong 08100Malaysia Centre for Virus and Vaccine Research&Department of Biological Sciences School of Medical and Life SciencesSunway UniversitySelangor 47500Malaysia Faculty of Medicine AIMST UniversityKedah 08100Malaysia School of Pharmaceutical Sciences(LIT-Pharmacy) Lovely Professional UniversityJalandhar 144411India Department of Pharmacy SMASGalgotias UniversityGreater Noida 203201India Department of Pharmaceutical Sciences Gurukul KangriHaridwarUttarakhand 249404India

In the current pandemic,COVID-19 patients with predisposing factors are at an increased risk of mucormycosis,an uncommon angioinvasive infection that is caused by fungi with Mucor genus which is mainly found in plants and *** development in COVID-19 patient is related to various factors,such as diabetes,immunocompromise and *** use of glucocorticoids for the treatment of critically ill COVID-19 patients also leads to opportunistic infections,such as pulmonary ***-19 patients with mucormycosis have a very high mortality *** review describes the pathogenesis and various treatment approaches for mucormycosis in COVID-19 patients,including medicinal plants,conventional therapies,adjunct and combination therapies.

关键词： mucormycosis COVID-19 Immunosuppression Pathogenesis Treatment

Colonic mucormycosis presented with ischemic colitis in a liver transplant recipient

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World Journal of Gastroenterology 2013年第22期19卷 3508-3511页

作者： Gi Won Do Seok Won Jung Jae-Bum Jun Jae Hee Seo Yang Won Nah Department of Internal Medicine University of Ulsan College of Medicine Ulsan University Hospital Dong-gu Ulsan 682-813 South Korea Department of Pathology University of Ulsan College of Medicine Ulsan University Hospital Dong-gu Ulsan 682-813 South Korea Division of Hepatobiliary Surgery and Liver Transplantation Department of Surgery University of Ulsan College of Medicine Ulsan University Hospital Dong-gu Ulsan 682-813 South Korea

mucormycosis is an uncommon opportunistic fungal infection with high mortality in liver transplant recipients. mucormycosis of the gastrointestinal tract can manifest with features similar to ischemic colitis. Typically signs and symptoms of non-gangrenous ischemic colitis resolve spontaneously within 24-48 h. On the other hand, the clinical course of the mucormycosis is commonly fulminant. We encountered a case of invasive fungal colitis presenting with abdominal pain and hematochezia in a liver transplant recipient. Endoscopic examination showed multiple shallow ulcerations and edema with mucosal friabilities on the sigmoid and distal descending colon, which was consistent with ischemic colitis. However, the histological examination obtained from endoscopic biopsies showed fungal hyphae withsurrounding inflammatory cells and mucosal necrosis. The patient was successfully managed with antifungal agent without surgical treatment. Thus, early diagnosis and treatment is essential for improving the prognosis of invasive fungal infection after liver transplantation.

关键词： mucormycosis Liver transplantation Colon Ischemia

mucormycosis in a diabetic ketoacidosis patient

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Asian Pacific Journal of Tropical Biomedicine 2013年第10期3卷 830-833页

作者： G.Sree Vijayabala Rajeshwari G Annigeri Ramachandran Sudarshan Department of Dentistry ESIC MedicalCollege and PGIMSRK.K.NagarChennaiIndia Department of Oral Medicine and Radiology College of Dental Sciences & HospitalDavangereIndia Department of Oral Medicine and Radiology Best Dental Science CollegeMaduraiIndia

Oral cavity is considered to be a kaleidoscope for body's general *** systemic conditions do present with diverse oral *** involving the oral cavity is one such entity that presents as necrosis of bone in immunocompromised *** is an opportunistic fungal infection that mainly affects the patients with uncontrolled diabetes ***,we report a case of mucormycosis involving the palate in a patient with diabetic ketoacidosis.

关键词： mucormycosis Diabetic ketoacidosis Palatal necrosis

Post COVID-19 mucormycosis:A case series

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Asian Pacific Journal of Tropical Medicine 2021年第11期14卷 517-524页

作者： Mala Vinod Kaneria Kallappa Baligeri Abhijeet Budhe Department of Medicine Topiwala National Medical College and B.Y.L.Nair Ch.HospitalMumbaiIndia

Objective:To evaluate the associated factors between COVID-19 and ***:Twenty-two patients of COVID-19 associated mucormycosis(including 3 asymptomatic patients who were cured of COVID-19)from a single medical unit of our institute were included.A detailed history was noted,with special emphasis on the time of onset of mucormycosis symptoms,presence of comorbidities,including new onset diabetes,severity of COVID-19,oxygen requirement,details of receipt of steroids and immunomodulators such as tocilizumab,imaging findings,including the number of sinuses involved,bony erosions,orbital and cerebral involvement,microscopy,culture and histopathology reports and antifungals *** interventions including number of debridements,orbital exenteration,maxillectomy,and the vaccination status were ***:All 22 patients had rhino-orbital cerebral mucormycosis,27.27%in the first wave and 72.73%during the second *** was the commonest comorbidity,and 40.91%patients were newly detected *** time of presentation in relation to their COVID-19 symptoms was 8-15 days(average 12.5 days).Ten out of 22(45.45%)had asymptomatic or mild COVID-19 and 40.91%did not require supplemental *** out of 22(22.73%)did not receive *** out of 22(54.55%)had orbital involvement,3(13.64%)had palatal ulcer and 4(18.18%)had cerebral involvement and all these had progressed in spite of treatment with appropriate ***:COVID-19 associated mucormycosis is a frequent,lethal,post COVID-19 complication,occurring even in mild and asymptomatic cases who have not received steroids or oxygen.

关键词： mucormycosis COVID-19 Steroids Amphotericin B

COVID-19-associated disseminated mucormycosis:An autopsy case report

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World Journal of Clinical Cases 2022年第28期10卷 10358-10365页

作者： Daisuke Kyuno Terufumi Kubo Mitsuhiro Tsujiwaki Shintaro Sugita Michiko Hosaka Hazuki Ito Keisuke Harada Akira Takasawa Yusaku Kubota Kumi Takasawa Yusuke Ono Kazufumi Magara Eichi Narimatsu Tadashi Hasegawa Makoto Osanai Department of Pathology Sapporo Medical UniversitySapporo 0608556HokkaidoJapan Department of Surgical Pathology Sapporo Medical UniversitySapporo 0608556Japan Department of Emergency Medicine Sapporo Medical UniversitySapporo 0608556Japan

BACKGROUND Reports of mucormycosis,an infectious disease that commonly affects immunocompromised individuals,have increased during the ongoing coronavirus disease 2019(COVID-19) *** mucormycosis associated with COVID-19 is rare but fatal and is characterized by an aggressive clinical course and delayed *** report documents a case of disseminated mucormycosis after COVID-19 *** is a rare pathological autopsy report on COVID-19-associated *** SUMMARY A 58-year-old man was transferred to our hospital with severe COVID-19 *** treatment for acute respiratory distress syndrome,he developed intra-abdominal bleeding that required a right hemicolectomy and ileostomy for *** ileostoma and surgical wound developed necrosis followed by sepsis and multi-organ failure,which led to *** autopsy revealed multiple thrombi associated with Rhizopus oryzae infection,which led to the necrosis of multiple infected *** Early suspicion and diagnosis followed by treatment are keys to better outcomes of mucormycosis in patients with severe COVID-19.

关键词： COVID-19 mucormycosis Mucorales infection Rhizopus oryzae SARS-Co V-2 Case report

mucormycosis: A Review on Environmental Fungal Spores and Seasonal Variation of Human Disease

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Advances in Infectious Diseases 2012年第3期2卷 76-81页

作者： Rima I. El-Herte Tania A. Baban Souha S. Kanj Division of Infectious Diseases Department of Internal Medicine American University of Beirut Medical Center Beirut Lebanon

mucormycosis is on the rise especially among patients with immunosuppressive conditions. There seems to be more cases seen at the end of summer and towards early autumn. Several studies have attempted to look at the seasonal variations of fungal pathogens in variou indoor and outdoor settings. Only two reports, both from the Middle East, have addressed the relationship of mucormycosis in human disease with climate conditions. In this paper we review, the relationship of indoor and outdoor fungal particulates to the weather conditions and the reported seasonal variation of human cases.

关键词： mucormycosis Seasonal Variation Fungal Air Particulate Concentration Mucor Rhizopus Rhinocerebral

Tuberculosis of Lymph Node Combined with Pulmonary mucormycosis

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中华医学杂志(英文版) 2015年第20期128卷 2812-2814页

作者： Yu Shan Chen Hong-Bing No. 4 Department of Tuberculosis No. 309 Hospital of PLA Beijing 100091 China

mucormycosis is a life-threatening fungal infection which often occurs in patients with underlying disease, and often resulting in a fatal outcome due to the difficulty of early diagnosis and its resi

关键词： Immunocompetence Lung mucormycosis Tuberculosis