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mucinous adenocarcinoma:A unique clinicopathological subtype in colorectal cancer

World Journal of Gastrointestinal Surgery 2021年第12期13卷 1567-1583页

作者： An Huang Yong Yang Jing-Yi Shi Yu-Kun Li Jing-Xuan Xu Yu Cheng Jin Gu Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Gastrointestinal Surgery IIIPeking University Cancer Hospital&InstituteBeijing 100142China Peking-Tsinghua Center for Life Science Peking University International Cancer CenterBeijing 100142China Department of Gastrointestinal Surgery Peking University Shougang HospitalBeijing 100144China

mucinous adenocarcinoma(MAC)is a unique clinicopathological subtype of colorectal cancer,which is characterized by extracellular mucinous components that comprise at least 50%of the tumor *** clinical characteristics,molecular features,response to chemo-/radiotherapy,and prognosis of MAC are different from that of non-MAC(NMAC).MAC is more common in the proximal colon,with larger volume,higher T-stage,a higher proportion of positive lymph nodes,poorer tumor differentiation,and a higher proportion of peritoneal implants compared to *** biopsy is the main diagnostic method for MAC,magnetic resonance imaging is superior in accuracy,especially for rectal *** aberrant expression of mucins,including MUC1,MUC2 and MUC5AC,is a notable feature of MAC,which may be related to tumor invasion,metastasis,inhibition of apoptosis,and chemo-/radiotherapy *** genetic origin of MAC is mainly related to BRAF mutation,microsatellite instability,and the CpG island methylator phenotype *** addition,the poor prognosis of rectal MAC has been confirmed by various studies,and that of colonic MAC is still *** this review,we summarize the epidemiology,clinicopathological characteristics,molecular features,methods of diagnosis,and treatments of MAC in order to provide references for further fundamental and clinical research.

关键词： mucinous adenocarcinoma Colorectal cancer Mucin Microsatellite instability Magnetic resonance imaging Treatment

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mucinous adenocarcinoma of the buttock associated with hidradenitis:A case report

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World Journal of Clinical Cases 2020年第18期8卷 4200-4206页

作者： Sung Jin Kim Tae Gon Kim Mi Jin Gu Sohyun Kim Department of Surgery College of MedicineYeungnam UniversityDaegu 42415South Korea Department of Plastic and Reconstructive Surgery College of MedicineYeungnam UniversityDaegu 42415South Korea Department of Pathology College of MedicineYeungnam UniversityDaegu 42415South Korea

BACKGROUND mucinous adenocarcinomas of the buttock are rare and have an uncertain etiology and natural *** are usually related to chronic anal fistulas,hidradenitis suppurativa,or Crohn's ***,we report a case of mucinous adenocarcinoma associated with hidradenitis and contradictory immunochemistry *** SUMMARY A 62-year-old man complained of recurrent abscesses of the buttock for 3 *** had several scars and nodules in bilateral buttocks,with purulent *** skin lesions did not appear to originate from the *** patient was diagnosed with recurrent abscesses due to hidradenitis suppurativa at the first *** showed purulent and subsequent mucin discharge in the first operation and was diagnosed with mucinous *** examinations were performed to determine disease origin and *** were no significant findings or evidence of anal ***,he underwent wide local excision and V-Y advancement flap in the second *** final diagnosis was mucinous adenocarcinoma without any evidence of anal *** immunochemistry test results were negative for cytokeratin(CK)7 and positive for CK20 and CDX2,with a colorectal origin.A pathologist suggested that the disease originated from a chronic anal *** patient has remained free of recurrence for 24 *** Although the patient with mucinous adenocarcinoma showed an atypical course,immunochemistry helped detect the disease origin.

关键词： mucinous adenocarcinoma Anal fistula Hidradenitis suppurativa Wide excision Immunochemistry test Case report

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Malignant transformation of pulmonary bronchiolar adenoma into mucinous adenocarcinoma:A case report

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World Journal of Clinical Cases 2023年第1期11卷 233-241页

作者： Xu-Ling Liu Cheng-Feng Miao Min Li Peng Li Department of Pathology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina

BACKGROUND Bronchiolar adenoma(BA)and ciliated muconodular papillary tumor are rare tumors that have bilayered cell proliferation and continuous expression of p40 and CK5/6 in the basal cell *** is difficult because of the limited knowledge of these tumors and their morphological similarities to malignant tumors,including invasive mucinous adenocarcinoma,especially based on the histopathology of intraoperative frozen *** tumors are now considered to be benign neoplasms,with malignant transformation reported in only a few *** SUMMARY A 57-year-old woman presented with a 17.0 mm×7.0 mm nodule in the lower lobe of the left ***-eosin staining and immunohistochemistry of a surgical specimen were *** tumor consisted of a BA area and a mucinous adenocarcinoma(MA)*** the BA area,the tumor had a bilayered structure of luminal cells and basal *** basal cells were positive for CK5/6 and p40,but the MA area was negative for these *** Ki-67 proliferation index was low(1%-2%).The patient was diagnosed with BA accompanied by MA,and had a favorable *** The present study indicated that BA may be carcinogenic,and suggests that clinicians should be aware of its potential for malignant transformation.

关键词： Bronchiolar adenoma Ciliated muconodular papillary tumors mucinous adenocarcinoma Malignant transformation Pulmonary Case report

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Cystic metastasis from a mucinous adenocarcinoma of duodenum mimicking type Ⅱ choledochal cyst: A case report

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World Journal of Gastrointestinal Oncology 2017年第12期9卷 492-496页

作者： Yo Na Kim Ji Soo Song Department of Pathology Chonbuk National University Medical School Research Institute for Endocrine Sciences Department of Radiology Chonbuk National University Medical School and Hospital Research Institute of Clinical Medicine of Chonbuk National University Biomedical Research Institute of Chonbuk National University Hospital

A 51-year-old male patient was referred to our hospital because of an incidentally detected cystic mass near the common bile duct(CBD). Imaging studies demonstrated a cystic mass that was suspected to communicate with the CBD. Gastroscopy showed irregular mucosal thickening with hyperemic change in the second portion of the duodenum. A type Ⅱ choledochal cyst combined with duodenal malignancy was suspected. The patient underwent surgical resection and the histological diagnosis was mucinous adenocarcinoma of the duodenum with cystic metastasis. Although its incidence is extremely rare, care should be taken to check for other sites of malignancy when a pericholedochal cystic mass is detected.

关键词： Duodenal cancer Choledochal cyst Cystic metastasis mucinous adenocarcinoma

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SIGNET-RING mucinous adenocarcinoma OF THE PANCREAS

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Chinese Medical Sciences Journal 1994年第3期9卷 176-178页

作者： W.H.Chow LouisT.C.Chow DepartmentofAnatomicalandCellularPathology PrinceofWalesHospitalShatinHongKong Consulatantphysician DepartmentofMedicineGranthamHospitalAberdeenHongKong.

An 88-year-old man presented symptoms and signs of ascending cholangitis and died 20 days after the onset of illness. Postmortem examination revealed a mucinous tumor arising from the head of the pancreas, encasing the common bile duct and invading the liver with multiple hepatic metastasis. The tumor showed a unique and uniform histological apperarance, consisting of signet-ring neoplastic cells floating in mucin pools. The rapid clinical course and widespread hepatic metastasis of this patient suggest that this pure, signet-ring variant of mucinous adenocarcinoma of the pancreas might have a poorer prognosis.

关键词： signet-ring carcinoma mucinous adenocarcinoma pancreas

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mucinous adenocarcinoma arising from a tailgut cyst: A case report

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World Journal of Clinical Oncology 2022年第10期13卷 853-860页

作者： Petra Malliou Antonia Syrnioti Triantafyllia Koletsa Eleni Karlafti Anestis Karakatsanis Georgia Raptou Stylianos Apostolidis Antonios Michalopoulos Daniel Paramythiotis The First Propaedeutic Surgery Department AHEPA University General Hospital of ThessalonikiThessaloniki 54636Greece Department of Pathology School of MedicineAristotle University of ThessalonikiThessaloniki 54636Greece Department of Emergency AHEPA University HospitalThessaloniki 54636Greece

BACKGROUND Retrorectal hamartomas or tailgut cysts(TCs)are *** most cases,they are asymptomatic and benign;however,rarely,they undergo malignant transformation,mainly in the form of *** SUMMARY A 55-year-old woman presented to our hospital with lower back *** magnetic resonance imaging,a large pelvic mass was found,which was located on the right of the ischiorectal fossa,extending to the minor *** patient underwent extensive surgical resection of the lesion through the right *** examination confirmed the diagnosis of a retrorectal mucinous adenocarcinoma originating from a *** resection of the tumour was complete,and the patient recovered without *** pilonidal sinus was then *** year later,semi-annual positron emission tomographycomputed tomography and magnetic resonance imaging scans did not reveal any evidence of local recurrence or metastatic *** Preoperative recognition,histological diagnosis,and treatment of TCs pose significant *** addition,the possibility of developing invasive mucinous adenocarcinoma,although rare,should be considered.

关键词： Retrorectal tumour mucinous adenocarcinoma Tailgut cyst Mucosal tumour Pilonidal cyst Case report

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Clinicopathologic features and survival of patients with colorectal mucinous, signet-ring cell or non-mucinous adenocarcinoma：experience at an institution in southern China

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Chinese Medical Journal 2009年第13期122卷 1486-1491页

作者： SONG Wu WU Sui-jing HE Yu-long CAI Shi-rong ZHANG Chang-hua ZHANG Xin-hua ZHAN Wen-hua Department of Gastrointestinal-pancreatic Surgery First Affiliated Hospital of Sun Yat-Sen University Guangzhou Guangdong 501800 China Department of Hematology Guangdong Provincial People's Hospital Guangzhou Guangdong 510080 China

Background Previous studies have shown conflicting results on the relation between clinicopathologic features and prognosis of patients with colorectal mucinous, signet-ring cell, or non-mucinous adenocarcinoma; only few such studies have been performed in China. This retrospective study analyzed data from our department to investigate clinicopathologic characteristics, prognosis and possible correlations of three histologic types - colorectal mucinous, signet-ring cell, and non-mucinous adenocarcinoma, to clarify the bases for observed differences which may lead to development of targeted therapies Methods Of 2079 patients diagnosed with colorectal cancer between 1994 and 2007, 144 had mucinous, 25 had signet-ring cell, and 1837 had non-mucinous adenocarcinoma. Their clinicopathologic parameters and survival were analyzed using established statistical methodologies. Results mucinous and signet-ring cell adenocarcinomas were common in younger patients （P 〈0.001）. Location, size and disease stage differed significantly among the three types. Signet-ring cell tumors were more commonly found in the rectum than mucinous and non-mucinous adenocarcinoma （P 〈0.001）. mucinous and signet-ring cell tumors presented in a later stage in life more often than non-mucinous adenocarcinoma, with lymph node involvement, serosal infiltration, peritoneal dissemination, and adjacent organ invasion （P 〈0.01）. The rate of radical resection, hepatic metastasis and local recurrence did not differ among types （P 〉0.05）. Compared with patients with non-mucinous adenocarcinoma, patients with mucinous and signet-ring cell tumors who underwent potentially curative resections or stage Ⅱ/Ⅲ disease had poorer long-term overall survival. Survival did not differ by type for patients with either stage Ⅰ or Ⅳ disease （P 〉0.05）. Conclusions mucinous and signet-ring cell adenocarcinoma have unique carcinogenesis and similar biologic behavior. Our study confirms that both histologic types, especially sign

关键词： colorectal carcinoma mucinous adenocarcinoma signet-ring cell carcinoma prognosis

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Local recurrence after successful endoscopic submucosal dissection for rectal mucinous mucosal adenocarcinoma:A case report

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World Journal of Gastrointestinal Oncology 2023年第1期15卷 186-194页

作者： Yuki Murakami Hiroki Tanabe Yusuke Ono Yuya Sugiyama Yu Kobayashi Takehito Kunogi Takahiro Sasaki Keitaro Takahashi Katsuyoshi Ando Nobuhiro Ueno Shin Kashima Sayaka Yuzawa Kentaro Moriichi Yusuke Mizukami Mikihiro Fujiya Toshikatsu Okumura Division of Metabolism and Biosystemic Science Department of Gastroenterology and Hematology/OncologyDepartment of MedicineAsahikawa Medical UniversityAsahikawa 078-8510HokkaidoJapan Institute of Biomedical Research Sapporo-Higashi Tokushukai HospitaSapporo 065-0033HokkaidoJapan Department of Diagnostic Pathology Asahikawa Medical UniversityAsahikawa 078-8510HokkaidoJapan

BACKGROUND mucinous adenocarcinoma of the colorectum is a rare histological subtype characterized by an abundant mucinous *** tumors are frequently diagnosed at an advanced stage,which indicates an aggressive ***,few case reports have been published,and little information is available concerning genetic alterations in mucinous *** SUMMARY A 76-year-old man underwent en bloc endoscopic submucosal dissection(ESD)for the management of a type 0-Is+IIa *** examination revealed an intramucosal mucinous adenocarcinoma with signet-ring cell carcinoma and well-to-moderately differentiated tubular *** years after the ESD,local recurrence was detected by an endoscopic examination,revealing a new 0-Is+IIa lesion with a phenotype similar to the previously resected ***-ESD was chosen for the management of the recurrent tumor,and the histological examination showed positive tumor infiltration at the vertical *** surgical resection was performed for the curative *** analysis showed pathogenic alterations in RNF43 and TP53 in the adenoma and an additional SMAD4 alteration in the *** This mucinous mucosal adenocarcinoma case was suggested to have an aggressive phenotype and a careful and close follow-up are required.

关键词： Rectal cancer mucinous adenocarcinoma Endoscopic submucosal dissectio TP53 Colitic cancer pathway Case report

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Epidemiologic characteristics and risk factors associated with overall survival for patients with mucinous colorectal cancer:A population-based study

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World Journal of Gastrointestinal Oncology 2023年第8期15卷 1461-1474页

作者： Jiao Jiang Xiao-Wei Tang Shu Huang Nan Hu Yuan Chen Bei Luo Wen-Sen Ren Yan Peng Wei-Xing Yang Mu-Han Lü Department of Gastroenterology the Affiliated Hospital of Southwest Medical UniversityLuzhou 646099Sichuan ProvinceChina Department of Gastroenterology the People’s Hospital of LianshuiHuaian 223400Jiangsu ProvinceChina

BACKGROUND mucinous adenocarcinoma(MC)has attracted much attention as a distinct histologic subtype of colorectal cancer in recent ***,data about its epidemiologic and prognostic characteristics are ***,patient data extracted from the National Cancer Institute’s Surveillance,Epidemiology,and End Results Program were collected to analyze the epidemiologic and clinicopathological characteristics of *** To determine the epidemiologic and clinicopathological characteristics of *** The incidence trend of MC was calculated through the Joinpoint Regression *** regression analyses were performed to identify prognostic factors associated with overall survival(OS).A nomogram was established to predict the survival probability of individual patients with *** We found that rates of MC decreased from 4.50/100000 in 2000 to 1.54/100000 in *** of MCs in patients aged≤50 years decreased 2.27%/year during *** incidence of appendiceal MCs increased from 0.14/100000 in 2000 to 0.24/100000 in 2018,while the incidence in other anatomic subsites continued to *** multivariable Cox analyses,age,race,tumor site,T stage,N stage,M stage,surgery,and chemotherapy were associated with OS.A nomogram was developed based on these factors,and the area under the curve for 1-year,3-year,and 5-year OS in the training cohort was 0.778,0.778,and 0.768,*** Our results demonstrated that MC incidence decreased in almost all anatomic subgroups except for the appendix.A nomogram predicting the survival probability of patients with MCs showed good performance.

关键词： mucinous adenocarcinoma Colorectal cancer Epidemiology Prognostic factor Nomogram Surveillance epidemiology and end results database

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The potential role of the three-dimensional-bioprinting model in screening and developing drugs

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World Journal of Gastroenterology 2022年第47期28卷 6788-6790页

作者： Chao-Lin Deng Bin Wu Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

Recently,we have read with great interest the original article used different spatial configuration models of colorectal cancer(CRC)for validating the antitumor efficacy with *** feel obliged to provide new insight into the drug screening models by integrating and analyzing the original method and *** comments may provide comprehensive insights into threedimensional drug screening models and the difference between pathologic subtypes in CRC.

关键词： Colorectal cancer three-dimensional-bioprinting mucinous adenocarcinoma Drug screening models

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