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Skeletal muscle cell apoptosis following motor nerve injury versus sensory nerve injury

Neural Regeneration Research 2011年第3期6卷 224-230页

作者： Zhao, Lei Xu, Ruisheng Jiang, Shenyang Lue, Guangming Yan, Zhiqiang Sun, Junming Wang, Ling Xue, Ye Jiang, Donglin Nantong Univ Affiliated Hosp 3 Clin Cent Lab Wuxi 214041 Jiangsu Peoples R China Nantong Univ Affiliated Hosp 3 Dept Orthoped Wuxi 214041 Jiangsu Peoples R China Nantong Univ Jiangsu Prov Key Lab Neuroregenerat Nantong 223001 Jiangsu Peoples R China Shanghai Jiao Tong Univ Inst Mechanobiol & Med Engn Shanghai 200030 Peoples R China

Skeletal muscle atrophy inevitably occurs in denervated skeletal muscle, and cell apoptosis plays an important role in skeletal muscle atrophy and degeneration. The present study established rat models of simple nerve injury by transecting the ventral or dorsal spinal nerve root and observed rat skeletal muscle cell apoptosis following simple motor nerve injury versus simple sensory nerve injury. Following skeletal muscle denervation for 10 weeks, cell apoptosis was detected in skeletal muscle, which was accompanied by obvious changes in rat behavior and electrophysiological responses. In addition, changes in cross-sectional area and average gray-scale of motor endplates of the gastrocnemius muscle were analyzed following sciatic nerve injury and motor nerve injury. Cell nuclei in denervated skeletal muscle tissue were more densely arranged than in normal skeletal muscle tissue. Cell nuclei were most dense in the sciatic nerve injury group, followed by the motor nerve injury group and the sensory nerve injury group. Fas/FasL expression and the number of apoptotic cells increased in denervated skeletal muscle, and apoptosis-related changes were observed. These findings suggested that motor and sensory nerves provided trophic actions following skeletal muscle and motor nerve injury, resulting in a greater influence on skeletal muscle atrophy than sensory nerve injury. Therefore, reconstruction of motor nerves should be preferentially considered for treating denervation-induced skeletal muscle atrophy.

关键词： apoptosis motor nerve rats sensory nerve skeletal muscle atrophy

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Protein expression of sensory and motor nerves Two-dimensional gel electrophoresis and mass spectrometry

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Neural Regeneration Research 2012年第5期7卷 369-375页

作者： Zhiwu Ren Yu Wang Jiang Peng Li Zhang Wenjing Xu Xiangdang Liang Qing Zhao Shibi Lu Key Laboratory of People＇s Liberation Army Institute of Orthopedics Chinese PLA General Hospital Beijing 100853 China Medical College of Nankai University Tianjin 300071 China Department of Orthopedics Chinese PLA General Hospital Beijing 100853 China Department of Orthopedics First Affiliated Hospital of Chinese PLA General Hospital Beijing 100037 China

The present study utilized samples from bilateral motor branches of the femoral nerve, as well as saphenous nerves, ventral roots, and dorsal roots of the spinal cord, to detect differential protein expression using two-dimensional gel electrophoresis and nano ultra-high performance liquid chromatography electrospray ionization mass spectrometry tandem mass spectrometry techniques. A mass spectrum was identified using the Mascot search. Results revealed differential expression of 11 proteins, including transgelin, Ig kappa chain precursor, plasma glutathione peroxidase precursor, an unnamed protein product （gil55628）, gfyceraldehyde-3-phosphate dehydrogenase-like protein, lactoylgfutathione lyase, adenyfate kinase isozyme 1, two unnamed proteins products （gil55628 and gi11334163）, and poly（rC）-binding protein 1 in motor and sensory nerves. Results suggested that these proteins played roles in specific nerve regeneration following peripheral nerve injury and served as specific markers for motor and sensory nerves.

关键词： differential protein expression mass spectrometry motor nerve peripheral nerve-specific regeneration two-dimensional gel electrophoresis sensory nerve

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Amplitude of sensory nerve action potential in early stage diabetic peripheral neuropathy:an analysis of 500 cases

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Neural Regeneration Research 2014年第14期9卷 1389-1394页

作者： Yunqian Zhang Jintao Li Tingjuan Wang Jianlin Wang Department of Neurology the Fourth Affiliated Hospital of Kunming Medical University Neuroscience Institute Kunming Medical University

Early diagnosis of diabetic peripheral neuropathy is important for the successful treatment of diabetes mellitus. In the present study, we recruited 500 diabetic patients from the Fourth Affiliated Hospital of Kunming Medical University in China from June 2008 to September 2013：221 cases showed symptoms of peripheral neuropathy （symptomatic group） and 279 cases had no symptoms of peripheral impairment （asymptomatic group）. One hundred healthy control subjects were also recruited. nerve conduction studies revealed that distal motor latency was longer, sensory nerve conduction velocity was slower, and sensory nerve action potential and amplitude of compound muscle action potential were significantly lower in the median, ulnar, posterior tibial and common peroneal nerve in the diabetic groups compared with control subjects. Moreover, the alterations were more obvious in patients with symptoms of peripheral neuropathy. Of the 500 diabetic patients, neural conduction abnormalities were detected in 358 cases （71.6%）, among which impairment of the common peroneal nerve was most prominent. Sensory nerve abnormality was more obvious than motor nerve abnormality in the diabetic groups. The amplitude of sensory nerve action potential was the most sensitive measure of peripheral neuropathy. Our results reveal that varying degrees of nerve conduction changes are present in the early, asymptomatic stage of diabetic peripheral neuropathy.

关键词： nerve regeneration peripheral nerve injury diabetic peripheral neuropathy neural con-duction electrophysiology sensory nerve motor nerve early diagnosis neural regeneration

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EMG analysis in 78 cases with motor neuron disease

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中国临床神经科学 2000年第Z1期8卷 83-页

作者： Zhang Qiubin Dept. of Neurology Harbin Railway Centrai ilospital

　　This paper analysed the FMGs of 78 cases with the motor neuron disease(MND). The EMG of all patients showed following characteristics that the average duration of wave prolonged, the average voltage increased and it was found that fibrillation and fasciculatton potentials appeared spontaneously. The fibrillation potential of ENG waa related to course of disease. In the patients whose course of disease was short, the fibri llation potential increased obviously, while in the cases of chronic MND, It usually decreased. The motor nerve conduction velocity of most pa tients (41%) reduced, however, the sensory nerve conduction velocity was normal but two. 　　We reviewed some references about EMG of the motor neuron disease and discussed their characteristics and

关键词： velocity of motor nerve

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